Detailed information of TA system TA219097

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-YafN
• Location: 2233804..2234339
• Replicon: chromosome
• Accession: NZ_CP084656
• Organism: Pectobacterium versatile strain SR1

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: LGL96_RS09840
• Protein ID: WP_225586319.1
• Coordinates: 2234052..2234339 (+)
• Length: 96 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: Q6DB37
• Locus tag: LGL96_RS09835
• Protein ID: WP_010281712.1
• Coordinates: 2233804..2234055 (+)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LGL96_RS09805 (LGL96_09805)	2229226..2229552	+	327	WP_103862833.1	helix-turn-helix domain-containing protein	-
LGL96_RS09810 (LGL96_09810)	2229537..2229851	+	315	WP_040032232.1	HipA N-terminal domain-containing protein	-
LGL96_RS09815 (LGL96_09815)	2229848..2230888	+	1041	WP_205539717.1	HipA domain-containing protein	-
LGL96_RS09820 (LGL96_09820)	2230949..2231572	-	624	WP_225586316.1	LysE family translocator	-
LGL96_RS09825 (LGL96_09825)	2231851..2232606	+	756	WP_225586317.1	thiol:disulfide interchange protein DsbG	-
LGL96_RS09830 (LGL96_09830)	2232641..2233546	-	906	WP_225586318.1	siderophore-interacting protein	-
LGL96_RS09835 (LGL96_09835)	2233804..2234055	+	252	WP_010281712.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
LGL96_RS09840 (LGL96_09840)	2234052..2234339	+	288	WP_225586319.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
LGL96_RS09845 (LGL96_09845)	2234494..2237277	+	2784	WP_225586320.1	AAA domain-containing protein	-
LGL96_RS09850 (LGL96_09850)	2237421..2238773	-	1353	WP_044207307.1	glutathione-disulfide reductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	2226436..2270671	44235

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-82)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 96 a.a.
• Molecular weight: 11017.06 Da
• Isoelectric Point: 10.2540

>T219097 WP_225586319.1 NZ_CP084656:2234052-2234339 [Pectobacterium versatile]
MSYSVKFREDALKEWLKLDKAIQQQFAKKLKKCCENPHIPSATLRGMKDCYKIKLRASGFRLVYEVIDDILVIAVVAVGK
RERSGVYHLASERMR

Nucleotide

• Length: 288 bp

>T219097 NZ_CP116181:645455-645769 [Escherichia coli]
ATGCACCTGATAACTCAAAAAGCATTGAAAGATGCTGCGGAAAAATACCCGCAACATAAAACGGAGTTGGTGGCTCTGGG
GAACACGATTGCTAAGGGATATTTCAAAAAACCTGAGTCATTAAAAGCAGTATTCCCTTCTCTGGATAACTTCAAATATC
TGGATAAGCATTATGTTTTCAATGTCGGGGGCAATGAATTACGTGTTGTAGCAATGGTCTTTTTTGAATCGCAAAAGTGC
TACATACGTGAAGTTATGACGCATAAAGAATACGATTTCTTTACCGCCGTTCATCGTACTAAGGGGAAAAAATGA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9117.47 Da
• Isoelectric Point: 4.0637

>AT219097 WP_010281712.1 NZ_CP084656:2233804-2234055 [Pectobacterium versatile]
MPNIILSDTSASVSELKKNPMATVNAGDGLPVAILNRNQPAFYCIPADLYEKMLDALDDQELVKLIGERKNQPLVDVDLD
SFL

Nucleotide

• Length: 252 bp

>AT219097 NZ_CP116181:645766-646182 [Escherichia coli]
ATGATTGCGATTGCCGACATCTTGCAAGCAGGAGAAAAGCTAACTGCTGTGGCACCTTTTCTGGCGGGTATTCAGAACGA
GGAACAATACACCCAGGCGCTGGAACTGGTAGATCATCTGCTGCTCAACGATCCTGAAAACCCCTTACTGGATCTGGTGT
GTGCCAAAATAACCGCGTGGGAAGAATCAGCGCCCGAATTTGTGGAATTTAATGCCATGGCTCAAGCCATGCCTGGCGGT
ATAGCCGTGATTCGTACCCTTATGGATCAATATGGTTTAACCCTTTCCGATCTTCCGGAAATAGGCAGTAAATCGATGGT
GTCACGCGTTTTGAGCGGGAAAAGGAAATTAACGCTGGAACACGCTAAAAAACTGGCAACGCGATTCGGTATTTCTCCCG
CCTTGTTTATTGATTAA

Structures

Antitoxin

• AlphaFold DB: A0A0M2EZP0