Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 1599034..1599584 Replicon chromosome
Accession NZ_CP084656
Organism Pectobacterium versatile strain SR1

Toxin (Protein)


Gene name ccdB Uniprot ID A0A3R8NCD5
Locus tag LGL96_RS06955 Protein ID WP_039483443.1
Coordinates 1599276..1599584 (+) Length 103 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID A0A3R8NHE1
Locus tag LGL96_RS06950 Protein ID WP_052012050.1
Coordinates 1599034..1599273 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LGL96_RS06930 (LGL96_06930) 1594514..1594825 - 312 WP_211024805.1 AzlD domain-containing protein -
LGL96_RS06935 (LGL96_06935) 1594822..1595556 - 735 WP_107333464.1 AzlC family ABC transporter permease -
LGL96_RS06940 (LGL96_06940) 1595662..1596498 - 837 WP_116362469.1 AraC family transcriptional regulator -
LGL96_RS06945 (LGL96_06945) 1596723..1598342 - 1620 WP_103942236.1 methyl-accepting chemotaxis protein -
LGL96_RS06950 (LGL96_06950) 1599034..1599273 + 240 WP_052012050.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
LGL96_RS06955 (LGL96_06955) 1599276..1599584 + 309 WP_039483443.1 CcdB family protein Toxin
LGL96_RS06960 (LGL96_06960) 1599725..1599889 - 165 WP_039483441.1 glucose uptake inhibitor SgrT -
LGL96_RS06965 (LGL96_06965) 1599980..1601638 + 1659 WP_225586577.1 HTH-type transcriptional regulator SgrR -
LGL96_RS06970 (LGL96_06970) 1601856..1602836 + 981 WP_145964249.1 thiamine ABC transporter substrate binding subunit -
LGL96_RS06975 (LGL96_06975) 1602812..1604419 + 1608 WP_103971083.1 thiamine/thiamine pyrophosphate ABC transporter permease ThiP -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-101)

Antitoxin

Post-segregation antitoxin CcdA

(9-79)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11785.63 Da        Isoelectric Point: 9.3363

>T219094 WP_039483443.1 NZ_CP084656:1599276-1599584 [Pectobacterium versatile]
MQYKVYRNNGNSNSYPYLLNIQSDIIGELHTRLVIPLFPLHKIARPPARRLTPIVTVEGNDYLIMTHEMASVRRSQLGHE
VMDAQVYRKTIKDAVDFLLDGF

Download         Length: 309 bp

>T219094 NZ_CP116181:190681-190788 [Escherichia coli]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9022.34 Da        Isoelectric Point: 10.0137

>AT219094 WP_052012050.1 NZ_CP084656:1599034-1599273 [Pectobacterium versatile]
MPVTSVRHKKTVSVTLEPVLLQQAREAGINLSAILTEALKREIRLSEGEKWKQQNQKALQELNRITDKHGLLSDDDRTF

Download         Length: 240 bp

>AT219094 NZ_CP116181:c190624-190567 [Escherichia coli]
TCAAGATTAGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3R8NCD5

Antitoxin

Source ID Structure
AlphaFold DB A0A3R8NHE1

References