Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 4841238..4841791 Replicon chromosome
Accession NZ_CP084655
Organism Pectobacterium brasiliense strain SR10

Toxin (Protein)


Gene name ccdB Uniprot ID -
Locus tag LGL97_RS21895 Protein ID WP_010287537.1
Coordinates 4841238..4841552 (-) Length 105 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID -
Locus tag LGL97_RS21900 Protein ID WP_010287535.1
Coordinates 4841555..4841791 (-) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LGL97_RS21870 (LGL97_21870) 4836417..4838279 + 1863 WP_225584160.1 type IV secretory system conjugative DNA transfer family protein -
LGL97_RS21875 (LGL97_21875) 4838288..4839034 + 747 WP_039320867.1 MobC family replication-relaxation protein -
LGL97_RS21880 (LGL97_21880) 4839413..4839907 + 495 WP_010287542.1 Lrp/AsnC family transcriptional regulator -
LGL97_RS21885 (LGL97_21885) 4839904..4840764 - 861 WP_010287540.1 EamA family transporter -
LGL97_RS21890 (LGL97_21890) 4840950..4841204 + 255 WP_039320862.1 hypothetical protein -
LGL97_RS21895 (LGL97_21895) 4841238..4841552 - 315 WP_010287537.1 CcdB family protein Toxin
LGL97_RS21900 (LGL97_21900) 4841555..4841791 - 237 WP_010287535.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
LGL97_RS21905 (LGL97_21905) 4842111..4843055 - 945 WP_159398235.1 zincin-like metallopeptidase domain-containing protein -
LGL97_RS21910 (LGL97_21910) 4843441..4844163 + 723 WP_072014229.1 MurR/RpiR family transcriptional regulator -
LGL97_RS21915 (LGL97_21915) 4844341..4845768 + 1428 WP_225584159.1 glycoside hydrolase family 1 protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 4815868..4867719 51851


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-103)

Antitoxin

Post-segregation antitoxin CcdA

(9-78)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 11493.40 Da        Isoelectric Point: 7.9859

>T219090 WP_010287537.1 NZ_CP084655:c4841552-4841238 [Pectobacterium brasiliense]
MQFTVYGNTGKSVVYPLLLDVTSDIIGQLNRRIAIPLLPIEKYPAGRRPDRLVPVVRLTDGKEYAVMTHELASIPVQALG
AVFCDASQYRSQVKAAIDFLIDGF

Download         Length: 315 bp

>T219090 NZ_CP116176:4865962-4866273 [Escherichia coli]
ATGCTCTTCATCGAAACGGAAATTTTTACTGAAGATGTTCAAAAACTGCTGACCGACGATGAATTCAGTCGTTTTCAGTT
TTTCCTGGCCTTGAATCCTGACTATGGTGAGGTAATACCTGAAACTGGTGGGTTAAGAAAGGTTCGATGGGTTTCAGGAG
GAAAGGGGAAACGTGCTGGTGTCAGGGTTATTTACTTTCATCAGGTTAAACATTATGAGATCAGATTACTGCTTATTTAT
CGTAAGGGTATTAAAGATGATCTGTCTCCCCAGGAAAAAGCAATGCTCCGGTTGTTAAATACGAGGTGGTAA

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8964.00 Da        Isoelectric Point: 6.7173

>AT219090 WP_010287535.1 NZ_CP084655:c4841791-4841555 [Pectobacterium brasiliense]
MTAKQRNTQSVTMTVERALLVRARAAGINLSATLTTALDAELRHHEAKKWQEENREAIDALNRFHDEQGCFSDEYRTF

Download         Length: 237 bp

>AT219090 NZ_CP116176:4866274-4866564 [Escherichia coli]
ATGGATAAGGCACTTTTTGAGCGGTTGACTCACAGCATGGCTCAGATGAATGAAATTATTGAAGGAACGCGACAGCCTTC
GCGGACTTTTGAAGTTGATGCTATGAAAATCAAAGAAATACGCCGCGCTTCAGGGTTGTCACAATCTAAATTTGCCGATC
TTATTTCTGTAAGCGTAGACACGTTGCGTAACTGGGAGCAGGGGCGACGTTCACCGACCGGGCCTGCAAAGGCTTTGCTG
CGAGCGATTGCCAATGATCCGCAACATGTGCTGCAAGCACTTAACCGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References