Detailed information of TA system TA021909

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 2787245..2787852
• Replicon: chromosome
• Accession: NC_008781
• Organism: Polaromonas naphthalenivorans CJ2

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: PNAP_RS25695
• Protein ID: WP_083758044.1
• Coordinates: 2787245..2787424 (+)
• Length: 60 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: A1VQL9
• Locus tag: PNAP_RS13210
• Protein ID: WP_011802024.1
• Coordinates: 2787439..2787852 (+)
• Length: 138 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
PNAP_RS13185	2782616..2783251	-	636	WP_041377258.1	response regulator transcription factor	-
PNAP_RS13190	2783244..2784650	-	1407	WP_011802020.1	integral membrane sensor signal transduction histidine kinase	-
PNAP_RS13195	2784733..2785296	-	564	WP_011802021.1	sel1 repeat family protein	-
PNAP_RS13205	2785967..2787208	+	1242	WP_011802022.1	integrase arm-type DNA-binding domain-containing protein	-
PNAP_RS25695	2787245..2787424	+	180	WP_083758044.1	type II toxin-antitoxin system HicA family toxin	Toxin
PNAP_RS13210	2787439..2787852	+	414	WP_011802024.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
PNAP_RS27010	2787960..2788490	+	531	WP_011802025.1	hypothetical protein	-
PNAP_RS13215	2788663..2788872	+	210	WP_041376700.1	AlpA family phage regulatory protein	-
PNAP_RS13220	2788963..2789250	+	288	WP_011802027.1	helix-turn-helix domain-containing protein	-
PNAP_RS27015	2789259..2789873	+	615	WP_157040286.1	hypothetical protein	-
PNAP_RS13230	2789870..2790214	+	345	WP_011802029.1	hypothetical protein	-
PNAP_RS13235	2790211..2790573	+	363	WP_011802030.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (4-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-127)

Sequences

Toxin

Protein

• Length: 60 a.a.
• Molecular weight: 6627.76 Da
• Isoelectric Point: 12.1525

>T21909 WP_083758044.1 NC_008781:2787245-2787424 [Polaromonas naphthalenivorans CJ2]
MTSAELIRDMQRAGWRLDRVNGSHHVFKHPSRPGHVVVPHPKKDLGLGLVKAIRRQAGI

Nucleotide

• Length: 180 bp

>T21909 NC_008781:2787245-2787424 [Polaromonas naphthalenivorans CJ2]
ATGACCAGCGCCGAATTGATACGTGATATGCAGCGGGCCGGATGGCGACTTGACCGGGTGAATGGTTCACACCACGTCTT
CAAGCACCCCAGCCGCCCCGGCCATGTTGTCGTGCCACACCCTAAAAAAGACCTGGGCCTGGGGCTGGTCAAGGCCATCC
GGCGGCAGGCCGGTATCTGA

Antitoxin

Protein

• Length: 138 a.a.
• Molecular weight: 14942.92 Da
• Isoelectric Point: 4.4411

>AT21909 WP_011802024.1 NC_008781:2787439-2787852 [Polaromonas naphthalenivorans CJ2]
MRYPITIEPGNDTTAWGVVVPDLPGCFSAGDTLEEAMIQAEDAVTAWIEVALDAGQDIPAPSHIEALRTAHPEFDGWLWA
LVKVDPAMLDDTVERVNISLPRRVLRRLDARARTAGETRSGFIARMAVEGREPAAHA

Nucleotide

• Length: 414 bp

>AT21909 NC_008781:2787439-2787852 [Polaromonas naphthalenivorans CJ2]
ATGCGCTACCCCATCACCATTGAACCCGGCAACGACACAACCGCCTGGGGCGTCGTGGTGCCTGATCTGCCCGGCTGCTT
TTCTGCGGGCGACACGCTCGAAGAAGCCATGATTCAGGCAGAGGACGCCGTGACCGCCTGGATTGAAGTCGCGCTCGACG
CCGGGCAGGACATTCCCGCGCCATCCCATATTGAAGCGCTGCGCACCGCCCATCCTGAATTTGACGGCTGGCTGTGGGCG
CTGGTGAAGGTTGACCCGGCCATGCTCGACGACACCGTGGAGCGGGTGAACATCAGCCTGCCGCGCCGCGTGTTGCGCCG
CCTGGATGCCCGTGCCCGCACGGCCGGCGAAACACGTTCCGGCTTCATTGCACGGATGGCCGTTGAAGGACGTGAGCCTG
CAGCGCACGCATAA

Structures

Antitoxin

• AlphaFold DB: A1VQL9