Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 3560928..3561560 Replicon chromosome
Accession NZ_CP084655
Organism Pectobacterium brasiliense strain SR10

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag LGL97_RS15965 Protein ID WP_072014142.1
Coordinates 3560928..3561104 (+) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag LGL97_RS15970 Protein ID WP_225584322.1
Coordinates 3561153..3561560 (+) Length 136 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LGL97_RS15925 (LGL97_15925) 3556261..3557193 + 933 WP_225584329.1 hypothetical protein -
LGL97_RS15930 (LGL97_15930) 3557190..3557534 + 345 WP_225584328.1 hypothetical protein -
LGL97_RS15935 (LGL97_15935) 3557527..3558009 + 483 WP_225584327.1 class I SAM-dependent methyltransferase -
LGL97_RS15940 (LGL97_15940) 3558006..3558352 + 347 Protein_3091 hypothetical protein -
LGL97_RS15945 (LGL97_15945) 3558509..3559102 + 594 WP_225584326.1 DUF1367 family protein -
LGL97_RS15950 (LGL97_15950) 3559099..3559896 + 798 WP_225584325.1 hypothetical protein -
LGL97_RS15955 (LGL97_15955) 3559889..3560173 + 285 WP_225584324.1 DUF1364 domain-containing protein -
LGL97_RS15960 (LGL97_15960) 3560170..3560745 + 576 WP_225584323.1 DUF1133 family protein -
LGL97_RS15965 (LGL97_15965) 3560928..3561104 + 177 WP_072014142.1 type II toxin-antitoxin system HicA family toxin Toxin
LGL97_RS15970 (LGL97_15970) 3561153..3561560 + 408 WP_225584322.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
LGL97_RS15975 (LGL97_15975) 3561655..3561960 + 306 WP_161502714.1 hypothetical protein -
LGL97_RS15980 (LGL97_15980) 3561957..3562430 + 474 WP_225584321.1 lysozyme -
LGL97_RS15985 (LGL97_15985) 3562415..3562942 + 528 WP_225584320.1 hypothetical protein -
LGL97_RS15990 (LGL97_15990) 3562966..3563481 + 516 WP_225584319.1 hypothetical protein -
LGL97_RS15995 (LGL97_15995) 3563593..3563847 + 255 WP_225584318.1 DNA polymerase III subunit theta -
LGL97_RS16000 (LGL97_16000) 3563924..3564121 + 198 WP_225584317.1 hypothetical protein -
LGL97_RS16005 (LGL97_16005) 3564332..3564970 + 639 WP_225584316.1 putative metallopeptidase -
LGL97_RS16010 (LGL97_16010) 3565003..3565488 + 486 WP_016060785.1 DUF2280 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 3544409..3622257 77848


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-63)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6725.79 Da        Isoelectric Point: 11.3427

>T219089 WP_072014142.1 NZ_CP084655:3560928-3561104 [Pectobacterium brasiliense]
VKQSEFRRWLESQGVEVSNGTNHLKLRYNGNRSVMPRHPSAEIKEPLRKAILKQLGLK

Download         Length: 177 bp

>T219089 NZ_CP116176:c4399825-4399550 [Escherichia coli]
ATGAGAACCAAGGTACAGGCTTTACGGAAGAAACAAAAAAATACATTGGATCAAATATTTAAAACTCCTGTTCCTCAAGG
GATCAAGTGGTCTGATATAGAGTCACTGGTTAAAGCATTAGGCGGAGAAATTAAGGAAGGAAGAGGTTCGCGTTGTAAGT
TCATACTAAATATGAGCGTTGCGTGTTTCCATCGGCCTCATCCGTCGCCAGATACCGATAAAGGCGCTGTAGAAAGCGTG
CGTGACTGGTTACTAAGTATAGGGGTAAAACCATGA

Antitoxin


Download         Length: 136 a.a.        Molecular weight: 14710.79 Da        Isoelectric Point: 4.3759

>AT219089 WP_225584322.1 NZ_CP084655:3561153-3561560 [Pectobacterium brasiliense]
MRYPVNLDPDSGGYVVSFPDIPEALTQGDTREDALKEALDALVTAFEFYFEDNQRIPAPGNITGDCVEVPASIAAKVLML
NAFVDSGLTQVELASRMGVKKQEVTRLFDLHHSTKIDTIQKAISAMGLRLELVAA

Download         Length: 408 bp

>AT219089 NZ_CP116176:c4399553-4399194 [Escherichia coli]
ATGATCAAACTGAAGACGCCAAACTCTATGGAGATTGCCGGGCAACCTGCAGTTATCACTTACGTGCCAGAACTGAATGC
ATTTCGTGGCAAATTCCTGGGCTTGTCAGGTTATTGTGATTTTGTCTCTGACAGCATTCAGGGGCTGCAAAAAGAAGGGG
AACTTTCCCTGCGAGAGTATCTTGAGGATTGTAAAGCTGCGGGTATTGAGCCGTATGCGCGTACAGAAAAGATTAAGACC
TTTACGTTACGCTATCCAGAATCGCTGAGTGAACGCCTTAATAATGCGGCTGCGCAGCAACAAGTCTCTGTTAATACCTA
TATTATTGAAACACTGAATGAGCGTTTGAATCATTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References