Detailed information of TA system TA219086

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/-
• Location: 2054803..2055437
• Replicon: chromosome
• Accession: NZ_CP084655
• Organism: Pectobacterium brasiliense strain SR10

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: LGL97_RS09160
• Protein ID: WP_080162911.1
• Coordinates: 2054803..2055078 (+)
• Length: 92 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: A0A0M2EWA4
• Locus tag: LGL97_RS09165
• Protein ID: WP_039317292.1
• Coordinates: 2055075..2055437 (+)
• Length: 121 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LGL97_RS09145 (LGL97_09145)	2051822..2053192	-	1371	WP_010281575.1	envelope stress sensor histidine kinase CpxA	-
LGL97_RS09150 (LGL97_09150)	2053189..2053887	-	699	WP_225583677.1	envelope stress response regulator transcription factor CpxR	-
LGL97_RS09155 (LGL97_09155)	2054041..2054565	+	525	WP_010281573.1	cell-envelope stress modulator CpxP	-
LGL97_RS09160 (LGL97_09160)	2054803..2055078	+	276	WP_080162911.1	type II toxin-antitoxin system HicA family toxin	Toxin
LGL97_RS09165 (LGL97_09165)	2055075..2055437	+	363	WP_039317292.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
LGL97_RS09170 (LGL97_09170)	2055810..2056997	+	1188	WP_225583675.1	sugar transporter	-
LGL97_RS09175 (LGL97_09175)	2057079..2057981	+	903	WP_010281569.1	CDF family cation-efflux transporter FieF	-
LGL97_RS09180 (LGL97_09180)	2058188..2059150	+	963	WP_010281567.1	6-phosphofructokinase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (30-85)

Antitoxin

• Uncharacterised protein family HicB (61-113)

Sequences

Toxin

Protein

• Length: 92 a.a.
• Molecular weight: 10024.61 Da
• Isoelectric Point: 11.1875

>T219086 WP_080162911.1 NZ_CP084655:2054803-2055078 [Pectobacterium brasiliense]
MQGKIASLRKKQRETLSQIFKTPVLSGVKWSNIESLVTALGGEIKEGSGSRVRFLLNGSIARFHRPHPSPDTDKGALVSL
REWLESIGVKP

Nucleotide

• Length: 276 bp

>T219086 NZ_CP116176:c3665039-3664704 [Escherichia coli]
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGTGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCTGG
ACATCGTCCAGCTGTTGTCCTGAGTCCTTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTGTACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACGGTTGTCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTACTGATTGGGTAG

Antitoxin

Protein

• Length: 121 a.a.
• Molecular weight: 13474.22 Da
• Isoelectric Point: 4.4969

>AT219086 WP_039317292.1 NZ_CP084655:2055075-2055437 [Pectobacterium brasiliense]
MTKALNTPNTMVVSGQPAIISYVPEIGMFRGKFIGLSGYCDFVADSINGLRSEGEISLREYLEDCQENGIEPYEREEKVK
TFTLRYPESFGERLTTAAAERQISVNTFIVETLSEHLKQA

Nucleotide

• Length: 363 bp

>AT219086 NZ_CP116176:c3665287-3665039 [Escherichia coli]
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCGGCTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGAGAGCCGAAAGATAAGGAA
GTCTGGTAA

Structures

Antitoxin

• AlphaFold DB: A0A0M2EWA4