Detailed information of TA system TA219083

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-YafN
• Location: 1759947..1760482
• Replicon: chromosome
• Accession: NZ_CP084655
• Organism: Pectobacterium brasiliense strain SR10

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: LGL97_RS07860
• Protein ID: WP_225584120.1
• Coordinates: 1760195..1760482 (+)
• Length: 96 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: Q6DB37
• Locus tag: LGL97_RS07855
• Protein ID: WP_010281712.1
• Coordinates: 1759947..1760198 (+)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LGL97_RS07825 (LGL97_07825)	1755008..1755322	+	315	WP_205535564.1	HipA N-terminal domain-containing protein	-
LGL97_RS07830 (LGL97_07830)	1755319..1756359	+	1041	WP_225584113.1	HipA domain-containing protein	-
LGL97_RS07835 (LGL97_07835)	1756419..1757042	-	624	WP_094431975.1	LysE family translocator	-
LGL97_RS07840 (LGL97_07840)	1757224..1757928	+	705	WP_225584115.1	SMI1/KNR4 family protein	-
LGL97_RS07845 (LGL97_07845)	1757998..1758753	+	756	WP_225584118.1	thiol:disulfide interchange protein DsbG	-
LGL97_RS07850 (LGL97_07850)	1758787..1759692	-	906	WP_048255948.1	siderophore-interacting protein	-
LGL97_RS07855 (LGL97_07855)	1759947..1760198	+	252	WP_010281712.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
LGL97_RS07860 (LGL97_07860)	1760195..1760482	+	288	WP_225584120.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
LGL97_RS07865 (LGL97_07865)	1760601..1761953	-	1353	WP_010281708.1	glutathione-disulfide reductase	-
LGL97_RS07870 (LGL97_07870)	1762082..1762924	-	843	WP_039316638.1	23S rRNA (adenine(2030)-N(6))-methyltransferase RlmJ	-
LGL97_RS07875 (LGL97_07875)	1763143..1763871	+	729	WP_225584122.1	DUF1266 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-84)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 96 a.a.
• Molecular weight: 11086.15 Da
• Isoelectric Point: 10.3527

>T219083 WP_225584120.1 NZ_CP084655:1760195-1760482 [Pectobacterium brasiliense]
MSYSVKFREDALKEWLKLDKTIQQQFAKKLKKCCENPHIPSAKLRGTKDCYKIKLRASGFRLIYEVIDDVLIIAVVAVGK
RERSGVYHLVSERMR

Nucleotide

• Length: 288 bp

>T219083 NZ_CP116176:c2839284-2839030 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGACGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9117.47 Da
• Isoelectric Point: 4.0637

>AT219083 WP_010281712.1 NZ_CP084655:1759947-1760198 [Pectobacterium brasiliense]
MPNIILSDTSASVSELKKNPMATVNAGDGLPVAILNRNQPAFYCIPADLYEKMLDALDDQELVKLIGERKNQPLVDVDLD
SFL

Nucleotide

• Length: 252 bp

>AT219083 NZ_CP116176:c2839532-2839281 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACAGAAAAGGAC
ATTATTGAGTGA

Structures

Antitoxin

• AlphaFold DB: A0A0M2EZP0