Detailed information of TA system TA219080

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-YafN
• Location: 1354595..1355120
• Replicon: chromosome
• Accession: NZ_CP084655
• Organism: Pectobacterium brasiliense strain SR10

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: LGL97_RS05965
• Protein ID: WP_039534786.1
• Coordinates: 1354595..1354879 (-)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: C6D956
• Locus tag: LGL97_RS05970
• Protein ID: WP_005973616.1
• Coordinates: 1354869..1355120 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LGL97_RS05950 (LGL97_05950)	1350832..1351968	-	1137	WP_052902156.1	lipase family protein	-
LGL97_RS05955 (LGL97_05955)	1352266..1353387	-	1122	WP_225582651.1	cupin domain-containing protein	-
LGL97_RS05960 (LGL97_05960)	1353478..1353906	-	429	WP_010284637.1	GNAT family N-acetyltransferase	-
LGL97_RS05965 (LGL97_05965)	1354595..1354879	-	285	WP_039534786.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
LGL97_RS05970 (LGL97_05970)	1354869..1355120	-	252	WP_005973616.1	prevent-host-death protein	Antitoxin
LGL97_RS05975 (LGL97_05975)	1355383..1357710	-	2328	WP_225582652.1	phage/plasmid primase, P4 family	-
LGL97_RS05980 (LGL97_05980)	1357721..1358062	-	342	WP_225582653.1	DUF5375 family protein	-
LGL97_RS05985 (LGL97_05985)	1358059..1358325	-	267	WP_012773411.1	hypothetical protein	-
LGL97_RS05990 (LGL97_05990)	1358322..1358516	-	195	WP_005973630.1	hypothetical protein	-
LGL97_RS05995 (LGL97_05995)	1358509..1358706	-	198	WP_225582714.1	host cell division inhibitor Icd-like protein	-
LGL97_RS06000 (LGL97_06000)	1358742..1359053	-	312	Protein_1174	ash family protein	-
LGL97_RS06005 (LGL97_06005)	1359062..1359286	-	225	WP_048256487.1	hypothetical protein	-
LGL97_RS06010 (LGL97_06010)	1359283..1359543	-	261	WP_225582654.1	AlpA family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-83)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 10980.93 Da
• Isoelectric Point: 10.1716

>T219080 WP_039534786.1 NZ_CP084655:c1354879-1354595 [Pectobacterium brasiliense]
MSYKLEFEEHALKEFKKLGAPVREQFTKKLKEVLQNPHVPANRLHGMADCYKIKLRSAGYRLVYQVLEHEIVVLVLAVGK
RERSEVYKAAKDRL

Nucleotide

• Length: 285 bp

>T219080 NZ_CP084655:c1354879-1354595 [Pectobacterium brasiliense]
ATGAGTTATAAGCTGGAGTTTGAAGAGCACGCGCTGAAAGAATTTAAGAAGCTGGGTGCACCCGTGCGGGAGCAGTTCAC
CAAAAAACTGAAAGAGGTTTTACAAAATCCCCACGTTCCCGCCAACCGGCTTCACGGAATGGCTGACTGCTACAAAATCA
AACTTCGTTCCGCTGGCTATCGGTTAGTGTATCAAGTGCTTGAGCATGAGATCGTGGTACTGGTTTTAGCTGTGGGCAAA
CGGGAACGCTCAGAGGTTTATAAAGCAGCCAAAGACCGATTATAA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9079.35 Da
• Isoelectric Point: 5.0807

>AT219080 WP_005973616.1 NZ_CP084655:c1355120-1354869 [Pectobacterium brasiliense]
MSVQPILANAAVSISDFKKSPNAALKEANGEPVAVLTNGRISGYYVSPETWEALADYQEDIELAKIARSRMKGKRVKVDL
DEL

Nucleotide

• Length: 252 bp

>AT219080 NZ_CP084655:c1355120-1354869 [Pectobacterium brasiliense]
ATGTCCGTACAACCTATTCTTGCCAATGCTGCCGTGAGTATTAGCGACTTTAAAAAATCGCCCAATGCCGCGCTGAAAGA
AGCTAACGGCGAGCCTGTAGCCGTGTTAACCAATGGCCGTATCTCTGGCTATTATGTTTCCCCGGAAACATGGGAAGCGC
TGGCCGACTATCAGGAAGATATCGAACTTGCCAAAATTGCCCGTTCCCGGATGAAGGGGAAACGTGTGAAGGTCGATCTG
GATGAGTTATAA

Structures

Antitoxin

• AlphaFold DB: A0A0G4JQP6