Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 1232525..1233051 Replicon chromosome
Accession NZ_CP084655
Organism Pectobacterium brasiliense strain SR10

Toxin (Protein)


Gene name ccdB Uniprot ID -
Locus tag LGL97_RS05490 Protein ID WP_225582604.1
Coordinates 1232746..1233051 (+) Length 102 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID -
Locus tag LGL97_RS05485 Protein ID WP_040036037.1
Coordinates 1232525..1232743 (+) Length 73 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LGL97_RS05455 (LGL97_05455) 1227796..1228371 + 576 WP_014914059.1 transcriptional regulator -
LGL97_RS05465 (LGL97_05465) 1228735..1229994 + 1260 WP_225582602.1 tyrosine-type recombinase/integrase -
LGL97_RS05470 (LGL97_05470) 1230089..1230283 - 195 WP_012773549.1 YlcI/YnfO family protein -
LGL97_RS05475 (LGL97_05475) 1230469..1230810 + 342 WP_039552182.1 hypothetical protein -
LGL97_RS05480 (LGL97_05480) 1231723..1232466 + 744 WP_225582603.1 MobC family replication-relaxation protein -
LGL97_RS05485 (LGL97_05485) 1232525..1232743 + 219 WP_040036037.1 type II toxin-antitoxin system antitoxin CcdA Antitoxin
LGL97_RS05490 (LGL97_05490) 1232746..1233051 + 306 WP_225582604.1 type II toxin-antitoxin system toxin CcdB Toxin
LGL97_RS05495 (LGL97_05495) 1233250..1233741 - 492 WP_225582605.1 hypothetical protein -
LGL97_RS05500 (LGL97_05500) 1233753..1235129 - 1377 WP_225582606.1 AAA family ATPase -
LGL97_RS05505 (LGL97_05505) 1235383..1235765 - 383 Protein_1075 GNAT family N-acetyltransferase -
LGL97_RS05510 (LGL97_05510) 1235762..1236055 - 294 WP_225582607.1 DUF1778 domain-containing protein -
LGL97_RS05515 (LGL97_05515) 1236399..1236638 - 240 WP_094433667.1 helix-turn-helix transcriptional regulator -
LGL97_RS05520 (LGL97_05520) 1236759..1237019 + 261 WP_094433668.1 helix-turn-helix transcriptional regulator -
LGL97_RS22140 1237582..1237791 - 210 WP_263868210.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 1228558..1236312 7754


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-100)

Antitoxin

Post-segregation antitoxin CcdA

(2-72)


Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 11731.56 Da        Isoelectric Point: 4.8500

>T219079 WP_225582604.1 NZ_CP084655:1232746-1233051 [Pectobacterium brasiliense]
MQFIVYQYKRASHYKMFVDVQSDIVETPKRRTVIPLIESHHLSEKVNKTLFPLIRIDGEDYRLMTTELSSVPVEVIGEVI
ADLGDYADEIKDAINLMFWGI

Download         Length: 306 bp

>T219079 NZ_CP116176:c1988977-1988870 [Escherichia coli]
ATGACGCTCGCGAAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGGATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 8229.22 Da        Isoelectric Point: 7.2038

>AT219079 WP_040036037.1 NZ_CP084655:1232525-1232743 [Pectobacterium brasiliense]
MKHRVSVTVDKDNYQVLSAAGVNISGLVNDVIGKEARRIKAEEWKKENREGMEEVARFIAQHGSFADENRNW

Download         Length: 219 bp

>AT219079 NZ_CP116176:1989030-1989091 [Escherichia coli]
TGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References