Detailed information of TA system TA219074

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 5078385..5079970
• Replicon: chromosome
• Accession: NZ_CP084654
• Organism: Pectobacterium versatile strain SR12

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: LGL95_RS22695
• Protein ID: WP_107333666.1
• Coordinates: 5078651..5079970 (+)
• Length: 440 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: LGL95_RS22690
• Protein ID: WP_010302402.1
• Coordinates: 5078385..5078651 (+)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LGL95_RS22665 (LGL95_22665)	5074530..5075084	+	555	WP_119159062.1	TetR/AcrR family transcriptional regulator	-
LGL95_RS22670 (LGL95_22670)	5075134..5075544	-	411	WP_103862408.1	helix-turn-helix domain-containing protein	-
LGL95_RS22675 (LGL95_22675)	5075687..5076538	+	852	WP_109225829.1	SDR family oxidoreductase	-
LGL95_RS22680 (LGL95_22680)	5076602..5077507	-	906	WP_103862407.1	HNH endonuclease	-
LGL95_RS22685 (LGL95_22685)	5077658..5078224	-	567	WP_103862406.1	hypothetical protein	-
LGL95_RS22690 (LGL95_22690)	5078385..5078651	+	267	WP_010302402.1	helix-turn-helix domain-containing protein	Antitoxin
LGL95_RS22695 (LGL95_22695)	5078651..5079970	+	1320	WP_107333666.1	type II toxin-antitoxin system HipA family toxin	Toxin
LGL95_RS22700 (LGL95_22700)	5080127..5081491	-	1365	WP_109225832.1	tRNA uridine-5-carboxymethylaminomethyl(34) synthesis GTPase MnmE	-
LGL95_RS22705 (LGL95_22705)	5081621..5083255	-	1635	WP_039485128.1	membrane protein insertase YidC	-
LGL95_RS22710 (LGL95_22710)	5083258..5083515	-	258	WP_010302384.1	membrane protein insertion efficiency factor YidD	-
LGL95_RS22715 (LGL95_22715)	5083479..5083838	-	360	WP_010302382.1	ribonuclease P protein component	-
LGL95_RS22720 (LGL95_22720)	5083857..5083997	-	141	WP_005976668.1	50S ribosomal protein L34	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (150-402)

Antitoxin

• Cro/C1-type helix-turn-helix domain (13-65)

Sequences

Toxin

Protein

• Length: 440 a.a.
• Molecular weight: 49253.37 Da
• Isoelectric Point: 6.5030

>T219074 WP_107333666.1 NZ_CP084654:5078651-5079970 [Pectobacterium versatile]
MAALDVYMNGYRVGILTKTGSGAHHFSYDANWLGLPGSRPISLSMPLRHQSYQGDEVYNFFDNLLPDNPDIRRRIVARHH
ADSTQPFDLLDKVGKDSVGALQIVPQGTPVHDIKKIEYKTLSEQQLENILTGYLSDAPLGMIDTEDDFRISIAGAQEKTA
LLYLDDHWCLPFSTTPTTHIIKLPIGKIESHSYSIDMSDSVENEYLCLLIAKAFGLPVPHCFMINAGKIKALAVERFDRK
YASDVSWIMRLPQEDFCQVLNVPSALKYENHGGPGISAIMSFLLGSVDPERDRYRFMQAQVLFWLLAATDGHAKNFSLFI
ESEGRYRLTPFYDILSMYPAMGGRGIDRREAKLAMGLTGSRGKKYAIEQIFPRHFFQTAKAVGFARESMENILAEFAQTV
ETVMTTVGSQLPVDFPTHISEAILAGLQARSRRLMSGWE

Nucleotide

• Length: 1320 bp

>T219074 NZ_CP116176:277991-278164 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 9887.16 Da
• Isoelectric Point: 9.7281

>AT219074 WP_010302402.1 NZ_CP084654:5078385-5078651 [Pectobacterium versatile]
MKVTNSKQLSSYLKDVRITQKLSQGKVASKVGIRQDTVSSFEQHPDSTKLETFFKILSALNLELTVTPRNVDTANNEASV
ASSWKEEW

Nucleotide

• Length: 267 bp

>AT219074 NZ_CP116176:277667-277963 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGGTT
AAGATCATTGATGTATGATATGAATTTCTCTTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAATT
CTTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTTAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAACATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG