219071

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-DnaT
Location 4624172..4624703 Replicon chromosome
Accession NZ_CP084654
Organism Pectobacterium versatile strain SR12

Toxin (Protein)


Gene name stbE Uniprot ID A0A249QBN7
Locus tag LGL95_RS20590 Protein ID WP_039493031.1
Coordinates 4624172..4624459 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID A0A3R8PFZ6
Locus tag LGL95_RS20595 Protein ID WP_039470361.1
Coordinates 4624449..4624703 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LGL95_RS20570 (LGL95_20570) 4619519..4620913 + 1395 WP_103971350.1 outer membrane channel protein TolC -
LGL95_RS20575 (LGL95_20575) 4621179..4621853 + 675 WP_103861630.1 DUF1190 family protein -
LGL95_RS20580 (LGL95_20580) 4621864..4623024 + 1161 WP_010297418.1 glutathionylspermidine synthase family protein -
LGL95_RS20585 (LGL95_20585) 4623211..4623996 - 786 WP_119158995.1 4,5-DOPA dioxygenase extradiol -
LGL95_RS20590 (LGL95_20590) 4624172..4624459 - 288 WP_039493031.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LGL95_RS20595 (LGL95_20595) 4624449..4624703 - 255 WP_039470361.1 plasmid stabilization protein Antitoxin
LGL95_RS20605 (LGL95_20605) 4625272..4626159 - 888 WP_119158996.1 16S rRNA (cytidine(1402)-2'-O)-methyltransferase -
LGL95_RS20610 (LGL95_20610) 4626221..4628239 + 2019 WP_226306000.1 penicillin-binding protein activator -
LGL95_RS20615 (LGL95_20615) 4628236..4628592 + 357 WP_039279491.1 YraN family protein -
LGL95_RS20620 (LGL95_20620) 4628781..4629371 + 591 WP_005975525.1 DnaA initiator-associating protein DiaA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-82)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10993.93 Da        Isoelectric Point: 10.7694

>T219071 WP_039493031.1 NZ_CP084654:c4624459-4624172 [Pectobacterium versatile]
MTYKLKFVPSALKEWKKLGHPVREQFKKKLVERLENPRVPSAQLHGRKDQYKIKLKSAGYRLVYLVQDETITVMVMGVGK
REGSQIYSDTKGRSA

Download         Length: 288 bp

>T219071 NZ_CP116170:58556-58972 [Escherichia coli]
GTGAACAAAACGTATATGCTGGACACCAACATCTGCTCTTTCATCATGCGCGAGCAGCCGGAAGCCGTCCTGAAGCGCCT
GGAGCAGGCGGTGCTGCGTGGCCACCGTATCGTGGTCTCGGCCATCACTTATTCCGAAATGCGCTTCGGGGCTACCGGCC
CGAAGGCCTCGCCGCGCCACGTGCAGCTGGTTGACGCGTTCTGCACCCGCCTCGATGCCATCCTGCCCTGGGATCGCGCC
GCGGTGGACGCGACCACGGAGATTAAGGTGGCGCTGCGCCTCGCCGGGACGCCGATCGGCCCGAACGACACGGCGATTGC
CGGACACTCCATCGCCGCCGGTGCCGTGCTGGTGACGAATAATACGCGGGAATTTGAACGGGTACCGGGTCTTGTGCTGG
AAGACTGGATAAGATAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9192.34 Da        Isoelectric Point: 3.7947

>AT219071 WP_039470361.1 NZ_CP084654:c4624703-4624449 [Pectobacterium versatile]
MAFNILTNTAASITELKRDPMGTVRAAEGETIAILNRNEPAFYCVPPAVFAYLMELAEDAELGRTVDDRMSELADAEEIS
PDDL

Download         Length: 255 bp

>AT219071 NZ_CP116170:58329-58559 [Escherichia coli]
ATGAGAACCGTATCCATTTTTAAAAACGGCAATAACCGCGCCATCCGTCTGCCCCGCGATCTTGATTTTGAGGGGGTGAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATCATCCTGCGCCCCGTCCGGCCGACCTGGGGCTCGTTCGCGAAGCTCG
AAAAAGCTGACCCGGACTTTATGGCGGAGCGCGAGGACGTTGTCACCGACGAAGGACGGGTTAACCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A249QBN7

Antitoxin

Source ID Structure
AlphaFold DB A0A3R8PFZ6

References