Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 4577269..4577861 Replicon chromosome
Accession NZ_CP084654
Organism Pectobacterium versatile strain SR12

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag LGL95_RS20390 Protein ID WP_103971367.1
Coordinates 4577607..4577861 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag LGL95_RS20385 Protein ID WP_095701362.1
Coordinates 4577269..4577610 (-) Length 114 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LGL95_RS20365 (LGL95_20365) 4572624..4573358 - 735 WP_226305991.1 type I-E CRISPR-associated protein Cas5/CasD -
LGL95_RS20370 (LGL95_20370) 4573368..4574435 - 1068 WP_226305992.1 type I-E CRISPR-associated protein Cas7/Cse4/CasC -
LGL95_RS20375 (LGL95_20375) 4574439..4575086 - 648 WP_010308671.1 type I-E CRISPR-associated protein Cse2/CasB -
LGL95_RS20380 (LGL95_20380) 4575070..4576638 - 1569 WP_103971368.1 type I-E CRISPR-associated protein Cse1/CasA -
LGL95_RS20385 (LGL95_20385) 4577269..4577610 - 342 WP_095701362.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
LGL95_RS20390 (LGL95_20390) 4577607..4577861 - 255 WP_103971367.1 type II toxin-antitoxin system HicA family toxin Toxin
LGL95_RS20395 (LGL95_20395) 4578173..4580899 - 2727 WP_116362404.1 CRISPR-associated helicase Cas3' -
LGL95_RS20400 (LGL95_20400) 4580936..4581487 - 552 WP_095701360.1 polymer-forming cytoskeletal protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(23-81)

Antitoxin

Uncharacterised protein family HicB

(55-100)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 9612.09 Da        Isoelectric Point: 11.2749

>T219070 WP_103971367.1 NZ_CP084654:c4577861-4577607 [Pectobacterium versatile]
MNKRHQRTLSDLFSRPVNSSIKWSDIESLFIALGAEIHEREGSRIAVLLKGEKKIFHRPHPRPTTDKGAVNSIRVWLESL
GVRP

Download         Length: 255 bp

>T219070 NZ_CP116169:c4598516-4598205 [Escherichia coli]
ATGCTCTTCATCGAAACGGAAATTTTTACTGAAGATGTTCAAAAACTGCTGACCGACGATGAATTCAGTCGTTTTCAGTT
TTTCCTGGCCTTGAATCCTGACTATGGTGAGGTAATACCTGAAACTGGTGGGTTAAGAAAGGTTCGATGGGTTTCAGGAG
GAAAGGGGAAACGTGCTGGTGTCAGGGTTATTTATTTTCATCAGGTTAAACATTATGAGATCAGATTACTGCTTATTTAT
CGTAAGGGTATTAAAGATGATCTGTCTCCCCAGGAAAAAGCAATGCTCCGGTTGTTAAATACGAGGTGGTAA

Antitoxin


Download         Length: 114 a.a.        Molecular weight: 12384.98 Da        Isoelectric Point: 4.4547

>AT219070 WP_095701362.1 NZ_CP084654:c4577610-4577269 [Pectobacterium versatile]
MINTLLIDGHTAVIAFDSEIEMFRGEFIGLNGGADFYAYSVDELKKEGATSLAIFLDECRRDGIEPYKSYSGKVTTRLTP
ERHAALAVTAQATGVSINELLNEGVDLVLERRS

Download         Length: 342 bp

>AT219070 NZ_CP116169:c4598204-4597914 [Escherichia coli]
ATGGATAAGGCACTTTTTGAGCGGTTGACTCACAGCATGGCCCAGATGAATGAAATTATTGAAGGAACGCGACAGCCTTC
GCGGACTTTTGAAGTTGATGCTATGAAAATCAAAGAAATACGCCGCGCTTCAGGGTTGTCACAATCTAAATTTGCCGATC
TTATTTCTGTAAGCGTAGACACGTTGCGTAACTGGGAGCAGGGGCGACGTTCACCGACCGGGCCTGCAAAGGCTTTGCTG
CGAGCGATTGCCAATGATCCGCAACATGTGCTGCAAGCACTTAACCGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References