Detailed information of TA system TA219065

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 4224461..4225121
• Replicon: chromosome
• Accession: NZ_CP084654
• Organism: Pectobacterium versatile strain SR12

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: LGL95_RS18780
• Protein ID: WP_103861404.1
• Coordinates: 4224461..4224874 (-)
• Length: 138 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: A0A1V2R9A9
• Locus tag: LGL95_RS18785
• Protein ID: WP_039355397.1
• Coordinates: 4224855..4225121 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LGL95_RS18755 (LGL95_18755)	4220239..4221567	+	1329	WP_103861399.1	MFS transporter	-
LGL95_RS18760 (LGL95_18760)	4221792..4222178	+	387	WP_103861400.1	thioesterase family protein	-
LGL95_RS18765 (LGL95_18765)	4222521..4223039	+	519	WP_103971790.1	flavodoxin FldB	-
LGL95_RS18770 (LGL95_18770)	4223068..4223391	+	324	WP_103971791.1	hypothetical protein	-
LGL95_RS18775 (LGL95_18775)	4223457..4224392	-	936	WP_130622686.1	23S rRNA (adenine(1618)-N(6))-methyltransferase RlmF	-
LGL95_RS18780 (LGL95_18780)	4224461..4224874	-	414	WP_103861404.1	protein YgfX	Toxin
LGL95_RS18785 (LGL95_18785)	4224855..4225121	-	267	WP_039355397.1	FAD assembly factor SdhE	Antitoxin
LGL95_RS18790 (LGL95_18790)	4225357..4226358	+	1002	WP_119158923.1	tRNA-modifying protein YgfZ	-
LGL95_RS18795 (LGL95_18795)	4226530..4227723	-	1194	WP_127032196.1	IS4 family transposase	-
LGL95_RS18800 (LGL95_18800)	4227936..4228583	-	648	WP_039539856.1	hemolysin III family protein	-
LGL95_RS18805 (LGL95_18805)	4228862..4229470	+	609	WP_095701613.1	HD domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	4226530..4227723	1193

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (2-132)

Antitoxin

• Flavinator of succinate dehydrogenase (8-79)

Sequences

Toxin

Protein

• Length: 138 a.a.
• Molecular weight: 16359.31 Da
• Isoelectric Point: 10.7911

>T219065 WP_103861404.1 NZ_CP084654:c4224874-4224461 [Pectobacterium versatile]
VAQWRCDLRVSWRMQLLSLVVHGLLVLFILLAPWPDGYAWLWLCLVTMVMFGFIRSQRNIKSRQGEIVLLSETTLNWRQQ
EWQIVKRPWLLKNGVLLSLQAVNAKDKQQLWLASDSMGDDEWRHLRQLLLQQKHWAR

Nucleotide

• Length: 414 bp

>T219065 NZ_CP116169:3494848-3495390 [Escherichia coli]
ATGGTCGACAAGCATGAAGAGATTACTCTGCCCATAGTCCTCTCCTGTAATTATCAGTCTGATATTACTTATCCTGGGCA
AAAACAGTTTGATTGCGGTAACCCTGTTATCGATAAATTTGTACGCGCATCGCTAAAGAAAAGTGTGCGTAATAGCGACT
GTGCGGCTAAAGCACTTATTGACAGACAAAGTGGTGAACTGATCGGCATCTGTACTTTTACGGCATATTCGCTGGAAAAA
CAACGCGTTTCTGGCGTCCTTCAGGGTTCACAACCTTCAGAAATTGGTGTTGTCAGATTAGTCATGTTGGGGGTAGCACG
GAAGTATCAAAAGCGGGGCTTTGGTCAGGACCTACTATGTGATTTTTTTGAACATGTAAAAATAATTCACCAGGCATTAC
CAATTAAAGGGGTTTATCTTGATGCTGACCCTGCCGCCATTAATTTTTATGCTCGTCTCGGCTTTGTTCAGCTTTCAGCG
ACACCAAATGCTTTTGGTGCTGTACCTATGTTTTTGGCGATTCAGCATATTCTCGCGGCTTAG

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10506.99 Da
• Isoelectric Point: 6.2223

>AT219065 WP_039355397.1 NZ_CP084654:c4225121-4224855 [Pectobacterium versatile]
MEIDNKSRIHWACRRGMRELDIAIMPFFEHDYDTLNDTDKRTFVRLLQSDDPDLFNWLMNHGEPKDGELKRMISLIQTRN
KDRGPVAM

Nucleotide

• Length: 267 bp

>AT219065 NZ_CP116169:3494553-3494864 [Escherichia coli]
ATGCCTGGAAAAACAGCCACTCTACCCGATGTCGATAAAACGCTGAAAAATGCGCGGGTCGAACTCAAAACCAGTCCCGA
CGCCAAAAACAAACTTCGTGAAGCTGCGCAAGCCGTTGGGGTAGATTTAAGCGCTTTTATTTTGAGCGCTGCTATGGAAC
GCGCCGAAAGTGTGCTTGATAACCAACGTCGCCGTGAGCTTTCGAATCAAAGCTGGGAACTGATGAACCAACTCATCGCT
GAACCTGCTCAACCGACGCTCGCCCTCAAGGCGTTAATGAAAAGGAAAAACAGCGATGGTCGACAAGCATGA

Structures

Antitoxin

• AlphaFold DB: A0A1V2R9A9