Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 3942481..3943007 Replicon chromosome
Accession NZ_CP084654
Organism Pectobacterium versatile strain SR12

Toxin (Protein)


Gene name ccdB Uniprot ID -
Locus tag LGL95_RS17545 Protein ID WP_119158864.1
Coordinates 3942702..3943007 (+) Length 102 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID -
Locus tag LGL95_RS17540 Protein ID WP_119158863.1
Coordinates 3942481..3942699 (+) Length 73 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LGL95_RS17520 (LGL95_17520) 3938845..3940104 + 1260 WP_130622535.1 integrase arm-type DNA-binding domain-containing protein -
LGL95_RS17525 (LGL95_17525) 3940557..3940898 + 342 WP_130622536.1 hypothetical protein -
LGL95_RS17530 (LGL95_17530) 3940950..3941537 - 588 WP_226305879.1 hypothetical protein -
LGL95_RS17535 (LGL95_17535) 3941679..3942422 + 744 WP_130622538.1 MobC family replication-relaxation protein -
LGL95_RS17540 (LGL95_17540) 3942481..3942699 + 219 WP_119158863.1 type II toxin-antitoxin system antitoxin CcdA Antitoxin
LGL95_RS17545 (LGL95_17545) 3942702..3943007 + 306 WP_119158864.1 type II toxin-antitoxin system toxin CcdB Toxin
LGL95_RS17550 (LGL95_17550) 3943134..3944393 - 1260 WP_119158865.1 GIY-YIG nuclease family protein -
LGL95_RS17555 (LGL95_17555) 3944395..3946404 - 2010 WP_193554739.1 helicase-related protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 3938664..3957039 18375


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-100)

Antitoxin

Post-segregation antitoxin CcdA

(2-72)


Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 11602.52 Da        Isoelectric Point: 5.0980

>T219061 WP_119158864.1 NZ_CP084654:3942702-3943007 [Pectobacterium versatile]
MQFIVYQYKRASHYTMFVDVQSDIVETPKRRMVIPLIESHHLSAKVNKTLFPLIRIDGEEYRLMTTELSSVPVEVIGEVI
ADLSDCADEIKGALNLMFWGI

Download         Length: 306 bp

>T219061 NZ_CP116169:2657850-2657957 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCGGCACCGATCCTGGCGGGGATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 8192.15 Da        Isoelectric Point: 7.0135

>AT219061 WP_119158863.1 NZ_CP084654:3942481-3942699 [Pectobacterium versatile]
MKHRVSVTVDKDNYQVLSAAGINISGLVNDAIGKEARRIKAEEWKKENREGMEEVARFIAQNGSFADENRNW

Download         Length: 219 bp

>AT219061 NZ_CP116169:c2657803-2657737 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References