Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3692551..3693176 Replicon chromosome
Accession NZ_CP084654
Organism Pectobacterium versatile strain SR12

Toxin (Protein)


Gene name Hha Uniprot ID C6DB72
Locus tag LGL95_RS16490 Protein ID WP_005976087.1
Coordinates 3692973..3693176 (+) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID C6DB73
Locus tag LGL95_RS16485 Protein ID WP_005976089.1
Coordinates 3692551..3692919 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LGL95_RS16470 (LGL95_16470) 3688181..3691309 + 3129 WP_103941781.1 efflux RND transporter permease subunit -
LGL95_RS16475 (LGL95_16475) 3691545..3691793 + 249 WP_039506474.1 type B 50S ribosomal protein L31 -
LGL95_RS16480 (LGL95_16480) 3691810..3691953 + 144 WP_005976091.1 type B 50S ribosomal protein L36 -
LGL95_RS16485 (LGL95_16485) 3692551..3692919 + 369 WP_005976089.1 Hha toxicity modulator TomB Antitoxin
LGL95_RS16490 (LGL95_16490) 3692973..3693176 + 204 WP_005976087.1 HHA domain-containing protein Toxin
LGL95_RS16500 (LGL95_16500) 3693920..3694240 + 321 WP_015839360.1 MGMT family protein -
LGL95_RS16505 (LGL95_16505) 3694260..3694841 - 582 WP_103970616.1 YbaY family lipoprotein -
LGL95_RS16510 (LGL95_16510) 3695054..3695917 + 864 WP_130640152.1 acyl-CoA thioesterase II -
LGL95_RS16515 (LGL95_16515) 3696052..3697338 - 1287 WP_161973278.1 ammonium transporter AmtB -
LGL95_RS16520 (LGL95_16520) 3697378..3697716 - 339 WP_002208627.1 P-II family nitrogen regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-118)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8145.52 Da        Isoelectric Point: 8.9008

>T219060 WP_005976087.1 NZ_CP084654:3692973-3693176 [Pectobacterium versatile]
MKKIDYLMRLRKCTTIDTLERVIEKNKYELSNDELEMFFSAADHRLAELTMNKLYDKVPTAVWRYVR

Download         Length: 204 bp

>T219060 NZ_CP116169:c2456991-2456815 [Escherichia coli]
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTAGCGAATGGCAGCAACCATTTGAAACTCAG
GTTTCATGGGAGGCGCAGTGTCATGCCGCGTCACCCCTGCGATGAGATTAAAGAACCATTGCGTAAAGCAATCCTGAAAC
AACTCGGTTTGAGTTAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14032.77 Da        Isoelectric Point: 4.4787

>AT219060 WP_005976089.1 NZ_CP084654:3692551-3692919 [Pectobacterium versatile]
MDEYTPKHYDIAQLRFLCENLCDESIATLGDSSHGWVNDPTSAINLQLNELIEHIATFILTFKIKYPNESELSEQVEKYL
DDTYVLFSNYGINDAELRRWQKSKAKLFGMFSGENVCTPAKT

Download         Length: 369 bp

>AT219060 NZ_CP116169:c2456769-2456353 [Escherichia coli]
ATGCGTTATCCCGTCACTCTTACACCCGCGCCGGAAGGCGGTTATATGGTTTCTTTTGTGGATATCCCTGAAGCGTTGAC
GCAGGGCGAAACTGTCGCTGAAGCGATGGAAGCGGCAAAAGATGCTTTACTGACCGCATTTGATTTTTATTTTGAAGATA
ACGAGCTTATCCCGTTACCTTCGCCATTAAATAGTCATGATCACTTTATTGAAGTACCTTTGAGCGTCGCCTCTAAAGTA
TTGCTGTTAAATGCTTTTTTACAGTCAGAAATCACTCAGCAAGAGTTAGCCAGGCGAATTGGCAAACCTAAACAGGAGAT
TACTCGCCTATTTAACTTGCACCATGCGACAAAAATCGACGCCGTCCAGCTTGCGGCAAAGGCGCTTGGCAAAGAGTTAT
CGCTGGTGATGGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1D7Z3F0

Antitoxin

Source ID Structure
AlphaFold DB A0A1D7Z3G5

References