Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1471743..1472377 Replicon chromosome
Accession NZ_CP084654
Organism Pectobacterium versatile strain SR12

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag LGL95_RS06570 Protein ID WP_226306240.1
Coordinates 1471743..1472147 (-) Length 135 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag LGL95_RS06575 Protein ID WP_226306241.1
Coordinates 1472147..1472377 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LGL95_RS06545 (LGL95_06545) 1466960..1468393 + 1434 WP_039545363.1 AMP-binding protein -
LGL95_RS06550 (LGL95_06550) 1468410..1468631 + 222 WP_005970017.1 acyl carrier protein -
LGL95_RS06555 (LGL95_06555) 1468858..1469736 + 879 WP_109224832.1 TauD/TfdA family dioxygenase -
LGL95_RS06560 (LGL95_06560) 1469733..1471166 + 1434 WP_226306239.1 FAD-binding protein -
LGL95_RS06565 (LGL95_06565) 1471257..1471403 - 147 Protein_1269 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
LGL95_RS06570 (LGL95_06570) 1471743..1472147 - 405 WP_226306240.1 tRNA(fMet)-specific endonuclease VapC Toxin
LGL95_RS06575 (LGL95_06575) 1472147..1472377 - 231 WP_226306241.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
LGL95_RS06580 (LGL95_06580) 1472472..1473305 - 834 WP_226306242.1 DUF4942 domain-containing protein -
LGL95_RS06585 (LGL95_06585) 1473423..1473743 - 321 WP_226306243.1 TA system toxin CbtA family protein -
LGL95_RS06590 (LGL95_06590) 1473812..1474147 - 336 WP_226306244.1 type IV toxin-antitoxin system YeeU family antitoxin -
LGL95_RS06595 (LGL95_06595) 1474187..1474660 - 474 WP_226306245.1 DNA repair protein RadC -
LGL95_RS06600 (LGL95_06600) 1474712..1475533 - 822 WP_226306246.1 DUF932 domain-containing protein -
LGL95_RS06605 (LGL95_06605) 1475615..1475827 - 213 WP_226306247.1 hypothetical protein -
LGL95_RS06610 (LGL95_06610) 1475860..1476267 - 408 WP_226306248.1 hypothetical protein -
LGL95_RS06615 (LGL95_06615) 1476310..1476675 - 366 WP_226306249.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1464173..1490425 26252


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-124)

Antitoxin

SpoVT-AbrB domain

(7-54)


Sequences

Toxin        


Download         Length: 135 a.a.        Molecular weight: 15077.32 Da        Isoelectric Point: 8.0253

>T219053 WP_226306240.1 NZ_CP084654:c1472147-1471743 [Pectobacterium versatile]
MLKYLLDTNICIYTIKNKPQEVRDAFYRHYGQFAISAITLMELIYGAEKSVNPEKNLAVIEGFSARMEVQTYGFDAAVHT
GQIRAELARQGTPIGPYDAMLAGHARSAGLILVTNNVREFERVPGLRVENWVSR

Download         Length: 405 bp

>T219053 NZ_CP116169:880516-880923 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCACTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGTGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8666.68 Da        Isoelectric Point: 4.3193

>AT219053 WP_226306241.1 NZ_CP084654:c1472377-1472147 [Pectobacterium versatile]
VEKTTVFKSNRSQAVRLPKAVALPDDVKQVDIVAIGRTRIITPAGESWDSWFEEEGVTPDFMITREQSDDQIREDF

Download         Length: 231 bp

>AT219053 NZ_CP116169:880269-880535 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References