Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 723323..723873 Replicon chromosome
Accession NZ_CP084654
Organism Pectobacterium versatile strain SR12

Toxin (Protein)


Gene name ccdB Uniprot ID A0A3R8NCD5
Locus tag LGL95_RS03205 Protein ID WP_039483443.1
Coordinates 723323..723631 (-) Length 103 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID A0A3R8NHE1
Locus tag LGL95_RS03210 Protein ID WP_052012050.1
Coordinates 723634..723873 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LGL95_RS03185 (LGL95_03185) 718488..720095 - 1608 WP_103942232.1 thiamine/thiamine pyrophosphate ABC transporter permease ThiP -
LGL95_RS03190 (LGL95_03190) 720071..721051 - 981 WP_145964249.1 thiamine ABC transporter substrate binding subunit -
LGL95_RS03195 (LGL95_03195) 721269..722927 - 1659 WP_039483436.1 HTH-type transcriptional regulator SgrR -
LGL95_RS03200 (LGL95_03200) 723018..723182 + 165 WP_039483441.1 glucose uptake inhibitor SgrT -
LGL95_RS03205 (LGL95_03205) 723323..723631 - 309 WP_039483443.1 CcdB family protein Toxin
LGL95_RS03210 (LGL95_03210) 723634..723873 - 240 WP_052012050.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
LGL95_RS03215 (LGL95_03215) 724565..726184 + 1620 WP_103942236.1 methyl-accepting chemotaxis protein -
LGL95_RS03220 (LGL95_03220) 726409..727245 + 837 WP_103861883.1 AraC family transcriptional regulator -
LGL95_RS03225 (LGL95_03225) 727351..728085 + 735 WP_103861882.1 AzlC family ABC transporter permease -
LGL95_RS03230 (LGL95_03230) 728082..728393 + 312 WP_103861881.1 AzlD domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-101)

Antitoxin

Post-segregation antitoxin CcdA

(9-79)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11785.63 Da        Isoelectric Point: 9.3363

>T219051 WP_039483443.1 NZ_CP084654:c723631-723323 [Pectobacterium versatile]
MQYKVYRNNGNSNSYPYLLNIQSDIIGELHTRLVIPLFPLHKIARPPARRLTPIVTVEGNDYLIMTHEMASVRRSQLGHE
VMDAQVYRKTIKDAVDFLLDGF

Download         Length: 309 bp

>T219051 NZ_CP116169:286904-287431 [Escherichia coli]
ATGGATGATCTGACGATAGAGATTCTGACCGATGATGCAGATTATGATCTACAGCGATTCGACTGCGGCGAGGAAGCGTT
AAATCTCTTTCTGACGACACATCTCGTTCGTCAACATCGCAACAAAATTCTGCGAGCGTATATCCTTTGTCGCAACACTC
CAGAACGTCAGGTGCTGGGATATTACACATTATGCGGCAGTTGTTTTGAACGAGCCGCATTGCCCTCGAAATCGAAACAG
AAAAAAATTCCCTACAAAAATATTCCCAGCGTTACTCTTGGGCGTCTGGCAATTGATCGTTCATTACAGGGGCAGGGATG
GGGAGCAACACTGGTTGCTCATGCCATGAAAGTCGTCTGGTCAGCCTCTTTAGCGGTAGGTATTCACGGTCTTTTTGTCG
AGGCGCTGAATAAAAAAGCCCATACGTTTTATCAATCGCTGGGCTTTATCCCGTTGGTCGGAGAAAACGAAAATGCGTTA
TTTTTCCCAACCAAATCCATCGAACTGCTTTTCACACAGAGCGATTAA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9022.34 Da        Isoelectric Point: 10.0137

>AT219051 WP_052012050.1 NZ_CP084654:c723873-723634 [Pectobacterium versatile]
MPVTSVRHKKTVSVTLEPVLLQQAREAGINLSAILTEALKREIRLSEGEKWKQQNQKALQELNRITDKHGLLSDDDRTF

Download         Length: 240 bp

>AT219051 NZ_CP116169:286631-286897 [Escherichia coli]
ATGTCTGCTGTTAAAAAGCAGCGTATCGATCTGCGTTTAACTGACGATGACAAAAGTATGATTGAGGAAGCGGCAGCGAT
ATCTAATCAGTCCGTCAGCCAATTTATGTTGAACAGCGCTTCGCAGCGGGCTGCGGAAGTGATTGAACAGCATCGGCGGG
TGATCCTCAATGAGGAATCCTGGACGCGGGTGATGGATGCGCTGAGTAATCCACCGTCACCTGGTGAAAAGCTAAAACGT
GCGGCAAAACGTCTTCAGGGAATGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3R8NCD5

Antitoxin

Source ID Structure
AlphaFold DB A0A3R8NHE1

References