Detailed information of TA system TA219048

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yeeV-yfjZ/CbtA-CbeA
• Location: 2981938..2982638
• Replicon: chromosome
• Accession: NZ_CP084652
• Organism: Yersinia ruckeri strain 16Y0180

Toxin (Protein)

• Gene name: yeeV
• Uniprot ID: A0A0A8VME3
• Locus tag: LGL93_RS13715
• Protein ID: WP_004722495.1
• Coordinates: 2981938..2982294 (+)
• Length: 119 a.a.

Antitoxin (Protein)

• Gene name: yfjZ
• Uniprot ID: A0A0A8VG75
• Locus tag: LGL93_RS13720
• Protein ID: WP_038251171.1
• Coordinates: 2982306..2982638 (+)
• Length: 111 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LGL93_RS13680 (LGL93_13715)	2977458..2978012	+	555	WP_004722507.1	hypothetical protein	-
LGL93_RS13685 (LGL93_13720)	2978015..2978506	+	492	WP_230596550.1	hypothetical protein	-
LGL93_RS13690 (LGL93_13725)	2978646..2978912	+	267	WP_038251173.1	hypothetical protein	-
LGL93_RS13695 (LGL93_13730)	2979411..2980232	+	822	WP_038251172.1	DUF932 domain-containing protein	-
LGL93_RS13700 (LGL93_13735)	2980594..2981025	+	432	WP_004722500.1	antirestriction protein	-
LGL93_RS13705 (LGL93_13740)	2981058..2981531	+	474	WP_004722498.1	DNA repair protein RadC	-
LGL93_RS13710 (LGL93_13745)	2981525..2981857	+	333	WP_050777623.1	DUF5983 family protein	-
LGL93_RS13715 (LGL93_13750)	2981938..2982294	+	357	WP_004722495.1	TA system toxin CbtA family protein	Toxin
LGL93_RS13720 (LGL93_13755)	2982306..2982638	+	333	WP_038251171.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
LGL93_RS13725 (LGL93_13760)	2982723..2983589	+	867	WP_004722491.1	DUF4942 domain-containing protein	-
LGL93_RS13730 (LGL93_13765)	2983774..2984097	+	324	WP_004722490.1	type II toxin-antitoxin system RelE/ParE family toxin	-
LGL93_RS13735 (LGL93_13770)	2984084..2984371	+	288	WP_012104592.1	helix-turn-helix transcriptional regulator	-
LGL93_RS13740 (LGL93_13775)	2984832..2985011	-	180	Protein_2668	tyrosine-type recombinase/integrase	-
LGL93_RS13745 (LGL93_13780)	2985747..2987525	+	1779	WP_234055420.1	glycosyltransferase family 2 protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	2973212..2990305	17093

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (12-101)

Antitoxin

• Antitoxin CbeA (9-108)

Sequences

Toxin

Protein

• Length: 119 a.a.
• Molecular weight: 12999.89 Da
• Isoelectric Point: 6.4771

>T219048 WP_004722495.1 NZ_CP084652:2981938-2982294 [Yersinia ruckeri]
MKPRPTAQGALPVPVIYQQLLAFLLEHHYGLSLNDTPYHDEQAIAQQIEQGISVGDTINALVEKYALVQIGRNGFSALAQ
DPMLSKGDIVRARQASGLWRAHFPPTLLYPTESLNPIP

Nucleotide

• Length: 357 bp

>T219048 NZ_CP116168:c89797-89492 [Escherichia coli]
ATGCAGTTTAAGGTTTACACCTATAAAAGAGAGAGCCGTTATCGTCTGTTTGTGGATGTCCAGAGTGACATTATTGACAC
GCCTGGGCGACGGATGGTGATCCCCCTGGCCAGTGCACGTCTGTTGTCAGATAAGGTCTCCCGTGAGCTTTACCCGGTGG
TGCATGTCGGGGATGAAAGCTGGCGCATGATGACCACCGATATGGCCAGTGTGCCGGTCTCCGTTATCGGGGAGGAAGTG
GCTGATCTCAGCCACCGAGAAAATGACATCAAAAATGCCATTAACCTGATGTTCTGGGGAATATAA

Antitoxin

Protein

• Length: 111 a.a.
• Molecular weight: 12102.74 Da
• Isoelectric Point: 7.3835

>AT219048 WP_038251171.1 NZ_CP084652:2982306-2982638 [Yersinia ruckeri]
MNNHITTSPTWGLKRDITPRLGARLVQEGTHLHFLSDRANIVGTFSPQAAQALDVAFPALITKLESQLLSGQLDPRRQQC
LTVRHGGFVCDADTLGSHGYVYIAVYQELS

Nucleotide

• Length: 333 bp

>AT219048 NZ_CP116168:c90017-89799 [Escherichia coli]
ATGAAGCAGCGCATTACAGTCACCGTCGACAGTGACAGCTATCAGTTGCTCAAGGCATATGATGTCAATATCTCCGGGCT
GGTAAGCACCACCCTGCAGAATGAAGCCCGTCGTCTGCGTGCCGAACGCTGGCAGGCAGAAAATCAGGAAGGGATGGCTG
AGGTCGCCCGGTTTATTGAAATGAACGGCTCTTTTGCCGACGAGAACAGGGACTGGTGA

Structures

Toxin

• AlphaFold DB: A0A0A8VME3

Antitoxin

• AlphaFold DB: A0A0A8VG75