Detailed information of TA system TA219038

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /RES-TIGR02293
• Location: 1924278..1925196
• Replicon: chromosome
• Accession: NZ_CP084652
• Organism: Yersinia ruckeri strain 16Y0180

Toxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: LGL93_RS08645
• Protein ID: WP_038242633.1
• Coordinates: 1924738..1925196 (+)
• Length: 153 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: A0A085U7R3
• Locus tag: LGL93_RS08640
• Protein ID: WP_038242631.1
• Coordinates: 1924278..1924724 (+)
• Length: 149 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LGL93_RS08620 (LGL93_08630)	1919976..1920680	+	705	WP_004717543.1	murein tripeptide amidase MpaA	-
LGL93_RS08625 (LGL93_08635)	1920691..1921665	-	975	WP_038251389.1	L-Ala-D/L-Glu epimerase	-
LGL93_RS08630 (LGL93_08640)	1921815..1922318	+	504	WP_004717547.1	thiol peroxidase	-
LGL93_RS08635 (LGL93_08645)	1922353..1923960	-	1608	WP_038251390.1	transcriptional regulator TyrR	-
LGL93_RS08640 (LGL93_08650)	1924278..1924724	+	447	WP_038242631.1	DUF2384 domain-containing protein	Antitoxin
LGL93_RS08645 (LGL93_08655)	1924738..1925196	+	459	WP_038242633.1	RES domain-containing protein	Toxin
LGL93_RS08650 (LGL93_08660)	1925200..1926258	-	1059	WP_038242635.1	YcjF family protein	-
LGL93_RS08655 (LGL93_08665)	1926255..1927652	-	1398	WP_004717556.1	YcjX family protein	-
LGL93_RS08660 (LGL93_08670)	1927633..1927875	-	243	WP_099511574.1	phage shock protein PspD	-
LGL93_RS08665 (LGL93_08675)	1927939..1928298	-	360	WP_004717559.1	envelope stress response membrane protein PspC	-
LGL93_RS08670 (LGL93_08680)	1928298..1928525	-	228	WP_038242637.1	envelope stress response membrane protein PspB	-
LGL93_RS08675 (LGL93_08685)	1928609..1929274	-	666	WP_004717561.1	phage shock protein PspA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (3-147)

Antitoxin

• Antitoxin Xre/MbcA/ParS-like, toxin-binding domain (94-145)

Sequences

Toxin

Protein

• Length: 153 a.a.
• Molecular weight: 17072.55 Da
• Isoelectric Point: 6.6384

>T219038 WP_038242633.1 NZ_CP084652:1924738-1925196 [Yersinia ruckeri]
VMLYRIVHNRYLATAWTGYGAETYGGRWNHKGHAAIYLASSVSLAMLETLVHVEDSATLNDFNLFQITIPDNAIMVLQQQ
DWPRGWRDDPTPVATMDIGTEWIGSVSSVGLLVPSTLVPLERNMLVNPKHRDFASCLKSINPLTFSFDPRLK

Nucleotide

• Length: 459 bp

>T219038 NZ_CP116166:1336190-1336588 [Escherichia coli]
ATGCTGAAATTCATGCTGGATACCAATATCTGTATTTTCACTATTAAGAATAAACCAGTACATGTCAGAGAGCGGTTTAA
CCTGAATTCTGGCCGGATGTGTATAAGTTCTGTAACATTGATGGAGCTTATCTATGGGGCAGAAAAAAGTCAGATGCCAG
AACGCAATTTGGCGGTTATTGAAGGTTTCGTATCTCGTTTGGTAGTGCTTGATTATGATAGTGCTGCTGCGACGCATACC
GGGCAAATCAGGGCCGAGCTTGCCCGGCAGGGAAGGCCTGTTGGACCTTTTGACCAGATGATAGCGGGACATGCTCGCAG
TCGCGGTTTGATTGTGGTTACCAACAATACCCGAGAGTTTGAGCGAGTGGCGGGAATCAGACTAGAAGACTGGAGCTAA

Antitoxin

Protein

• Length: 149 a.a.
• Molecular weight: 16406.87 Da
• Isoelectric Point: 8.0956

>AT219038 WP_038242631.1 NZ_CP084652:1924278-1924724 [Yersinia ruckeri]
MRTYHPSPMAKVSALWREIGLPASRGTALVDSIKLGFTVDVIDTIHLWADMPKSEILRATGIPSRSLTRRRTHDGRFTPE
ESERIARFVRVMDAAVDLFGGDRTKATAWMSMPVKGLGNRTPDSLLETETGALEICDLIGRLEHGVFS

Nucleotide

• Length: 447 bp

>AT219038 NZ_CP116166:1335963-1336190 [Escherichia coli]
ATGGAAACTACTGTATTTTTAAGTAATCGCAGTCAGGCCGTCAGATTACCGAAAGCGGTCGCTCTGCCAGAAGACGTTAA
GAAAGTAGAAATTATTGCGATTGGTCGTACAAGAATCATCACTCCCGCCGGTGAGTCCTGGGACAGTTGGTTTGATGGCG
AAAATGTGAGTGCGGATTTTATGGATATCCGTGATCAACCCGCAATGCAGGAAAGGGAATCATTTTGA

Structures

Antitoxin

• AlphaFold DB: A0A085U7R3