Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) ykfI-yeeU/CbtA-CbeA
Location 1061990..1062753 Replicon chromosome
Accession NZ_CP084652
Organism Yersinia ruckeri strain 16Y0180

Toxin (Protein)


Gene name ykfI Uniprot ID A0A0A8VGU6
Locus tag LGL93_RS04820 Protein ID WP_004720097.1
Coordinates 1062433..1062753 (+) Length 107 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A0A8VB89
Locus tag LGL93_RS04815 Protein ID WP_004720095.1
Coordinates 1061990..1062358 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LGL93_RS04770 (LGL93_04770) 1057016..1057843 + 828 WP_004720076.1 hypothetical protein -
LGL93_RS04775 (LGL93_04775) 1057923..1058804 + 882 WP_230596577.1 50S ribosome-binding GTPase -
LGL93_RS04780 (LGL93_04780) 1059051..1059605 + 555 WP_004720086.1 hypothetical protein -
LGL93_RS04785 (LGL93_04785) 1059608..1060099 + 492 WP_004720088.1 hypothetical protein -
LGL93_RS04790 (LGL93_04790) 1060154..1060510 + 357 WP_004720091.1 hypothetical protein -
LGL93_RS04795 (LGL93_04795) 1060654..1060770 + 117 Protein_929 DUF945 domain-containing protein -
LGL93_RS04800 (LGL93_04800) 1060797..1061249 + 453 WP_004720092.1 antirestriction protein -
LGL93_RS04805 (LGL93_04805) 1061261..1061740 + 480 WP_004720093.1 DNA repair protein RadC -
LGL93_RS04810 (LGL93_04810) 1061744..1061956 + 213 WP_139127562.1 antirestriction protein -
LGL93_RS04815 (LGL93_04815) 1061990..1062358 + 369 WP_004720095.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
LGL93_RS04820 (LGL93_04820) 1062433..1062753 + 321 WP_004720097.1 TA system toxin CbtA family protein Toxin
LGL93_RS04825 (LGL93_04825) 1062871..1063704 + 834 WP_038251289.1 DUF4942 domain-containing protein -
LGL93_RS04830 (LGL93_04830) 1064628..1064978 + 351 WP_038251290.1 transcriptional regulator -
LGL93_RS04835 (LGL93_04835) 1065053..1066342 + 1290 WP_004720102.1 arsenic transporter -
LGL93_RS04840 (LGL93_04840) 1066355..1066780 + 426 WP_004720103.1 glutaredoxin-dependent arsenate reductase -
LGL93_RS04845 (LGL93_04845) 1067050..1067694 + 645 WP_038243845.1 thermostable hemolysin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-105)

Antitoxin

Antitoxin CbeA

(19-117)


Sequences

Toxin        


Download         Length: 107 a.a.        Molecular weight: 12149.92 Da        Isoelectric Point: 6.0642

>T219037 WP_004720097.1 NZ_CP084652:1062433-1062753 [Yersinia ruckeri]
MQTLPVSPTREAQLGPSPAAVWKQLLTHLFEHHYGLTLNDTPFCYEFVIQEHIESGILLKDAVNFVVERYGLLRIDRSSF
SFDEPSPFINFTDILRARRAIGLMNT

Download         Length: 321 bp

>T219037 NZ_CP116166:1102298-1102609 [Escherichia coli]
ATGCACATCATTTCTAAAGCGCCATTTGAAGAGTCTGCGCGTAAATATCCTAACGACGCTCTGGCTCTTCAGGCATTGTA
TCGGGTTATTAAGGAAACGGATTTTTCTACACCAGAAGAAATGCGAACGGCGTTTCCCAACCTCGACAATTTTAGATATC
GCAACAAATGGTACGTTCTGGATGTCGGCGGGAACAATCTTAGGGTTATTGCCTACATAAACTTTGTTAATAAGCGGTTC
TTTGTGAAGCACATAACGAATCACGCAGAGTATGACAAACTGACACGTTACTACAGAGAGAACAAAGAATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13456.42 Da        Isoelectric Point: 6.9468

>AT219037 WP_004720095.1 NZ_CP084652:1061990-1062358 [Yersinia ruckeri]
MKPTPSKTIPPKDTTACLQWGLRHDITPCFGARLVQEGQRLHFLADRAGFCGVFSEEGARHLDQAFPLIMKQLELALLSG
ELDPRYQRSITLSHNGLTCEADALGSHGYVYITIYPTPSVTA

Download         Length: 369 bp

>AT219037 NZ_CP116166:1102606-1103025 [Escherichia coli]
ATGACTGCTAATGCTGCACGCGCTGTTAAAGCAACAAGAGAACTGGTCAATGCAGTCCCCTTTCTGGGAGGCAGTGACTC
AGAAGATGATTATCGTGAAGCACTGGAACTGGTCGAATATTTGATTGAAGAAGATGACACCAATCCACTTATCGACTTTC
TGGCGAGCCGCATTGCAGAGTATGAAAACAACAACGAAAAGTTTGCAGAGTTCGACAAAGCCGTTGCGGCAATGCCGGTT
GGCGTGGCGTTACTTCGCACGTTGATTGATCAACATAATCTGACCTATGCGGATTTGAAGAACGAAATCGGCTCTAAATC
CCTGGTCAGTCAGATTTTGTCTGGACAACGATCCCTGACGATATCCCACATTAAGGCACTTTCAGCCCGATTTGGCGTTA
AGCCGGAATGGTTTCTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0A8VGU6

Antitoxin

Source ID Structure
AlphaFold DB A0A0A8VB89

References