Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 974528..975151 Replicon chromosome
Accession NZ_CP084652
Organism Yersinia ruckeri strain 16Y0180

Toxin (Protein)


Gene name Hha Uniprot ID A0A085U5C4
Locus tag LGL93_RS04410 Protein ID WP_038243726.1
Coordinates 974528..974731 (-) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A085U5C5
Locus tag LGL93_RS04415 Protein ID WP_004718732.1
Coordinates 974783..975151 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LGL93_RS04385 (LGL93_04385) 970383..970721 + 339 WP_007886947.1 P-II family nitrogen regulator -
LGL93_RS04390 (LGL93_04390) 970760..972049 + 1290 WP_004718723.1 ammonium transporter AmtB -
LGL93_RS04395 (LGL93_04395) 972164..973027 - 864 WP_004718726.1 acyl-CoA thioesterase II -
LGL93_RS04400 (LGL93_04400) 973405..973719 - 315 WP_004718728.1 MGMT family protein -
LGL93_RS04410 (LGL93_04410) 974528..974731 - 204 WP_038243726.1 expression modulating protein YmoA Toxin
LGL93_RS04415 (LGL93_04415) 974783..975151 - 369 WP_004718732.1 Hha toxicity modulator TomB Antitoxin
LGL93_RS04420 (LGL93_04420) 976200..976361 + 162 WP_004718735.1 hypothetical protein -
LGL93_RS04425 (LGL93_04425) 976480..976623 - 144 WP_004718738.1 type B 50S ribosomal protein L36 -
LGL93_RS04430 (LGL93_04430) 976643..976897 - 255 WP_038243728.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8037.27 Da        Isoelectric Point: 6.4573

>T219036 WP_038243726.1 NZ_CP084652:c974731-974528 [Yersinia ruckeri]
MTKTDYLMRLRKCTTIDTLERVIEKNKYELSDDELELFYSAADHRLAELTMNKLYDKIPATVWQHVK

Download         Length: 204 bp

>T219036 NZ_CP116166:1036057-1036392 [Escherichia coli]
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCTGG
ACATCGTCCAGCTGTTGTCCTGAGTCCTTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTGTACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACAGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTACTGATTGGGTAG

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14277.08 Da        Isoelectric Point: 4.4225

>AT219036 WP_004718732.1 NZ_CP084652:c975151-974783 [Yersinia ruckeri]
MDEYSPKRHDIAQLKFLCENLYDEGIATLGDSHHGWVNDPTSAVNLQLNDLIEHIASFVMSFKIKYADEIDLCELVEEYL
DDTYTLFSSYGINDPDLRRWQKTKDRLFRLFSGEYLCALMKN

Download         Length: 369 bp

>AT219036 NZ_CP116166:1035809-1036057 [Escherichia coli]
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCGGCTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGAGAGCCGAAAGATAAGGAA
GTCTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A085U5C4

Antitoxin

Source ID Structure
AlphaFold DB A0A085U5C5

References