Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeV-yfjZ/CbtA-CbeA
Location 3082368..3083068 Replicon chromosome
Accession NZ_CP084650
Organism Yersinia ruckeri strain 17Y0153

Toxin (Protein)


Gene name yeeV Uniprot ID A0A0A8VME3
Locus tag LGL87_RS14335 Protein ID WP_004722495.1
Coordinates 3082368..3082724 (+) Length 119 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID A0A0A8VG75
Locus tag LGL87_RS14340 Protein ID WP_038251171.1
Coordinates 3082736..3083068 (+) Length 111 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LGL87_RS14300 (LGL87_14315) 3077888..3078442 + 555 WP_004722507.1 hypothetical protein -
LGL87_RS14305 (LGL87_14320) 3078445..3078936 + 492 WP_230596550.1 hypothetical protein -
LGL87_RS14310 (LGL87_14325) 3079076..3079342 + 267 WP_038251173.1 hypothetical protein -
LGL87_RS14315 (LGL87_14330) 3079841..3080662 + 822 WP_038251172.1 DUF932 domain-containing protein -
LGL87_RS14320 (LGL87_14335) 3081024..3081455 + 432 WP_004722500.1 antirestriction protein -
LGL87_RS14325 (LGL87_14340) 3081488..3081961 + 474 WP_004722498.1 DNA repair protein RadC -
LGL87_RS14330 (LGL87_14345) 3081955..3082287 + 333 WP_050777623.1 DUF5983 family protein -
LGL87_RS14335 (LGL87_14350) 3082368..3082724 + 357 WP_004722495.1 TA system toxin CbtA family protein Toxin
LGL87_RS14340 (LGL87_14355) 3082736..3083068 + 333 WP_038251171.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
LGL87_RS14345 (LGL87_14360) 3083153..3084019 + 867 WP_004722491.1 DUF4942 domain-containing protein -
LGL87_RS14350 (LGL87_14365) 3084204..3084527 + 324 WP_004722490.1 type II toxin-antitoxin system RelE/ParE family toxin -
LGL87_RS14355 (LGL87_14370) 3084514..3084801 + 288 WP_012104592.1 helix-turn-helix transcriptional regulator -
LGL87_RS14360 (LGL87_14375) 3085262..3085441 - 180 Protein_2789 tyrosine-type recombinase/integrase -
LGL87_RS14365 (LGL87_14380) 3086177..3087955 + 1779 WP_234055087.1 glycosyltransferase family 2 protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 3073643..3090735 17092


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(12-101)

Antitoxin

Antitoxin CbeA

(9-108)


Sequences

Toxin        


Download         Length: 119 a.a.        Molecular weight: 12999.89 Da        Isoelectric Point: 6.4771

>T219034 WP_004722495.1 NZ_CP084650:3082368-3082724 [Yersinia ruckeri]
MKPRPTAQGALPVPVIYQQLLAFLLEHHYGLSLNDTPYHDEQAIAQQIEQGISVGDTINALVEKYALVQIGRNGFSALAQ
DPMLSKGDIVRARQASGLWRAHFPPTLLYPTESLNPIP

Download         Length: 357 bp

>T219034 NZ_CP116166:760349-760645 [Escherichia coli]
ATGGAAAAACGCACACCACATACACGTTTGAGTCAGGTTAAAAAACTTGTCAATACCGGGCAAGTTCGTACAACACGTAG
TGCACTGTTAAATGCAGATGAGTTAGGTTTGGATTTTGATGGTATGTGTAATGTTATCATTGGATTATCAGAGAGCGACT
TTTATAAAAGCATGACCACCTACTCTGATCATACTATCTGGCAGGATGTTTACAGACCCAGGCTTGTTACAGGCCAGGTT
TATCTTAAAATTACGGTAATTCATGACGTACTGATCGTCTCGTTTAAGGAGAAGTAA

Antitoxin


Download         Length: 111 a.a.        Molecular weight: 12102.74 Da        Isoelectric Point: 7.3835

>AT219034 WP_038251171.1 NZ_CP084650:3082736-3083068 [Yersinia ruckeri]
MNNHITTSPTWGLKRDITPRLGARLVQEGTHLHFLSDRANIVGTFSPQAAQALDVAFPALITKLESQLLSGQLDPRRQQC
LTVRHGGFVCDADTLGSHGYVYIAVYQELS

Download         Length: 333 bp

>AT219034 NZ_CP116166:760647-761042 [Escherichia coli]
ATGAAATGTCCGGTTTGCCACCAGGGAGAAATGGTTTCTGGCATTAAAGATATTCCATACACCTTCCGTGGACGAAAAAC
AGTATTGAAAGGTATCCACGGTTTATATTGTGTCCATTGCGAAGAGAGCATCATGAATAAAGAAGAGTCAGATGCTTTCA
TGGCGCAAGTAAAGGCATTTCGGGCTTCGGTGAATGCCGAAACAGTGGCACCTGAATTTATAGTGAAGGTTCGAAAAAAG
CTCTCTCTTACCCAAAAAGAGGCAAGCGAAATTTTTGGGGGAGGTGTAAATGCGTTTTCGCGTTACGAAAAAGGCAATGC
CCAACCTCATCCTTCCACAATCAAACTTTTACGTGTTCTGGATAAGCATCCAGAACTATTGAATGAAATCCGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0A8VME3

Antitoxin

Source ID Structure
AlphaFold DB A0A0A8VG75

References