Detailed information of TA system TA219033

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 3002694..3003363
• Replicon: chromosome
• Accession: NZ_CP084650
• Organism: Yersinia ruckeri strain 17Y0153

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: A0A380QS17
• Locus tag: LGL87_RS13945
• Protein ID: WP_038241020.1
• Coordinates: 3002694..3003116 (-)
• Length: 141 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: -
• Locus tag: LGL87_RS13950
• Protein ID: WP_004719196.1
• Coordinates: 3003097..3003363 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LGL87_RS13925 (LGL87_13940)	2998533..3000266	-	1734	WP_004719191.1	single-stranded-DNA-specific exonuclease RecJ	-
LGL87_RS13930 (LGL87_13945)	3000273..3000989	-	717	WP_004719192.1	bifunctional protein-disulfide isomerase/oxidoreductase DsbC	-
LGL87_RS13935 (LGL87_13950)	3001021..3001920	-	900	WP_004719193.1	site-specific tyrosine recombinase XerD	-
LGL87_RS13940 (LGL87_13955)	3002028..3002546	+	519	WP_038241022.1	flavodoxin FldB	-
LGL87_RS13945 (LGL87_13960)	3002694..3003116	-	423	WP_038241020.1	protein YgfX	Toxin
LGL87_RS13950 (LGL87_13965)	3003097..3003363	-	267	WP_004719196.1	FAD assembly factor SdhE	Antitoxin
LGL87_RS13955 (LGL87_13970)	3003657..3004649	+	993	WP_038241018.1	tRNA-modifying protein YgfZ	-
LGL87_RS13960 (LGL87_13975)	3004788..3005462	-	675	WP_049687854.1	hemolysin III family protein	-
LGL87_RS13965 (LGL87_13980)	3005770..3006026	+	257	Protein_2712	HD domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (2-132)

Antitoxin

• Flavinator of succinate dehydrogenase (7-79)

Sequences

Toxin

Protein

• Length: 141 a.a.
• Molecular weight: 16451.41 Da
• Isoelectric Point: 11.1478

>T219033 WP_038241020.1 NZ_CP084650:c3003116-3002694 [Yersinia ruckeri]
VAQWRCDLRVSWRTQLFSLLVHGVLVLLTLVVPWPDGFTPLWLILLTLVVFECIRSQKNITSRQGEIRLKAGNLLIWKWQ
EWTLVRPPWITRYGVLLSLQGAGSRRRKRIWLASDSMSEEKWRELCLILRHTFDSAAGRE

Nucleotide

• Length: 423 bp

>T219033 NZ_CP116166:c636342-635878 [Escherichia coli]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGATGCTTTAGTTGC
CGAAGTCGAGGCATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCTGCCACAAAGTTATTGGCGGTGGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGCTATCGTCTCTTCTTTCGTTACAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACGCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGTAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAAGCCTCACCCAAGAGACAGAAGAAAACCATTGA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10532.09 Da
• Isoelectric Point: 6.7185

>AT219033 WP_004719196.1 NZ_CP084650:c3003363-3003097 [Yersinia ruckeri]
MEIDNKARIHWACRRGMRELDISIMPFFEHEYDTLNDNDKRVFIRLLTSDDPDLFNWLMNHGEPQDSELKRMVKLIQTRN
KARGPVAM

Nucleotide

• Length: 267 bp

>AT219033 NZ_CP116166:c636677-636342 [Escherichia coli]
ATGCCCGCTAATGCTCGCTCTCACGCTGTACTGACCACTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCAGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTCTTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCAACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA

Structures

Toxin

• AlphaFold DB: A0A380QS17