Detailed information of TA system TA219024

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /RES-TIGR02293
• Location: 1927565..1928483
• Replicon: chromosome
• Accession: NZ_CP084650
• Organism: Yersinia ruckeri strain 17Y0153

Toxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: LGL87_RS08680
• Protein ID: WP_038242633.1
• Coordinates: 1928025..1928483 (+)
• Length: 153 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: A0A085U7R3
• Locus tag: LGL87_RS08675
• Protein ID: WP_038242631.1
• Coordinates: 1927565..1928011 (+)
• Length: 149 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LGL87_RS08655 (LGL87_08650)	1923263..1923967	+	705	WP_004717543.1	murein tripeptide amidase MpaA	-
LGL87_RS08660 (LGL87_08655)	1923978..1924952	-	975	WP_038251389.1	L-Ala-D/L-Glu epimerase	-
LGL87_RS08665 (LGL87_08660)	1925102..1925605	+	504	WP_004717547.1	thiol peroxidase	-
LGL87_RS08670 (LGL87_08665)	1925640..1927247	-	1608	WP_038251390.1	transcriptional regulator TyrR	-
LGL87_RS08675 (LGL87_08670)	1927565..1928011	+	447	WP_038242631.1	DUF2384 domain-containing protein	Antitoxin
LGL87_RS08680 (LGL87_08675)	1928025..1928483	+	459	WP_038242633.1	RES domain-containing protein	Toxin
LGL87_RS08685 (LGL87_08680)	1928487..1929545	-	1059	WP_038242635.1	YcjF family protein	-
LGL87_RS08690 (LGL87_08685)	1929542..1930939	-	1398	WP_004717556.1	YcjX family protein	-
LGL87_RS08695 (LGL87_08690)	1930920..1931162	-	243	WP_099511574.1	phage shock protein PspD	-
LGL87_RS08700 (LGL87_08695)	1931226..1931585	-	360	WP_004717559.1	envelope stress response membrane protein PspC	-
LGL87_RS08705 (LGL87_08700)	1931585..1931812	-	228	WP_038242637.1	envelope stress response membrane protein PspB	-
LGL87_RS08710 (LGL87_08705)	1931896..1932561	-	666	WP_004717561.1	phage shock protein PspA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (3-147)

Antitoxin

• Antitoxin Xre/MbcA/ParS-like, toxin-binding domain (94-145)

Sequences

Toxin

Protein

• Length: 153 a.a.
• Molecular weight: 17072.55 Da
• Isoelectric Point: 6.6384

>T219024 WP_038242633.1 NZ_CP084650:1928025-1928483 [Yersinia ruckeri]
VMLYRIVHNRYLATAWTGYGAETYGGRWNHKGHAAIYLASSVSLAMLETLVHVEDSATLNDFNLFQITIPDNAIMVLQQQ
DWPRGWRDDPTPVATMDIGTEWIGSVSSVGLLVPSTLVPLERNMLVNPKHRDFASCLKSINPLTFSFDPRLK

Nucleotide

• Length: 459 bp

>T219024 NZ_CP116159:c4183423-4183073 [Escherichia coli]
ATGGTAAAGAAAAGTGAATTTGAACGGGGAGACATTGTGCTGGTTGGCTTTGATCCAGCAAGCGGCCATGAACAGCAAGG
TGCTGGTCGACCTGCGCTTGTGCTCTCCGTTCAAGCCTTTAATCAACTGGGAATGACGCTGGTGGCCCCCATTACGCAGG
GTGGAAATTTTGCCCGTTATGCCGGATTTAGCGTTCCTTTACATTGCGAAGAAGGCGATGTGCACGGCGTGGTGCTGGTT
AATCAGGTGCGGATGATGGATCTACGCGCCCGGCTGGCAAAGCGTATTGGTCTGGCTGCGGATGAGGTGGTGGAAGAGGC
GTTATTACGCTTGCAGGCGGTGGTGGAATAA

Antitoxin

Protein

• Length: 149 a.a.
• Molecular weight: 16406.87 Da
• Isoelectric Point: 8.0956

>AT219024 WP_038242631.1 NZ_CP084650:1927565-1928011 [Yersinia ruckeri]
MRTYHPSPMAKVSALWREIGLPASRGTALVDSIKLGFTVDVIDTIHLWADMPKSEILRATGIPSRSLTRRRTHDGRFTPE
ESERIARFVRVMDAAVDLFGGDRTKATAWMSMPVKGLGNRTPDSLLETETGALEICDLIGRLEHGVFS

Nucleotide

• Length: 447 bp

>AT219024 NZ_CP116159:c4183668-4183417 [Escherichia coli]
ATGCGTATTACCATAAAAAGATGGGGGAACAGTGCAGGTATGGTCATTCCCAATATCGTAATGAAAGAACTTAACTTACA
GCCGGGGCAGAGCGTGGAAGCGCAGGTGAGCAACAACCAACTGATTCTGACACCCATCTCCAGGCGCTACTCGCTTGATG
AACTGCTGGCACAGTGTGACATGAACGCCGCGGAACTTAGCGAGCAGGATGTCTGGGGTAAATCCACCCCTGCGGGTGAC
GAAATATGGTAA

Structures

Antitoxin

• AlphaFold DB: A0A085U7R3