Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) ykfI-yeeU/CbtA-CbeA
Location 1061958..1062721 Replicon chromosome
Accession NZ_CP084650
Organism Yersinia ruckeri strain 17Y0153

Toxin (Protein)


Gene name ykfI Uniprot ID A0A0A8VGU6
Locus tag LGL87_RS04840 Protein ID WP_004720097.1
Coordinates 1062401..1062721 (+) Length 107 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A0A8VB89
Locus tag LGL87_RS04835 Protein ID WP_004720095.1
Coordinates 1061958..1062326 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LGL87_RS04790 (LGL87_04795) 1056984..1057811 + 828 WP_004720076.1 hypothetical protein -
LGL87_RS04795 (LGL87_04800) 1057891..1058772 + 882 WP_230596577.1 50S ribosome-binding GTPase -
LGL87_RS04800 (LGL87_04805) 1059019..1059573 + 555 WP_004720086.1 hypothetical protein -
LGL87_RS04805 (LGL87_04810) 1059576..1060067 + 492 WP_004720088.1 hypothetical protein -
LGL87_RS04810 (LGL87_04815) 1060122..1060478 + 357 WP_004720091.1 hypothetical protein -
LGL87_RS04815 (LGL87_04820) 1060622..1060738 + 117 Protein_932 DUF945 domain-containing protein -
LGL87_RS04820 (LGL87_04825) 1060765..1061217 + 453 WP_004720092.1 antirestriction protein -
LGL87_RS04825 (LGL87_04830) 1061229..1061708 + 480 WP_004720093.1 DNA repair protein RadC -
LGL87_RS04830 (LGL87_04835) 1061712..1061924 + 213 WP_139127562.1 antirestriction protein -
LGL87_RS04835 (LGL87_04840) 1061958..1062326 + 369 WP_004720095.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
LGL87_RS04840 (LGL87_04845) 1062401..1062721 + 321 WP_004720097.1 TA system toxin CbtA family protein Toxin
LGL87_RS04845 (LGL87_04850) 1062839..1063672 + 834 WP_038251289.1 DUF4942 domain-containing protein -
LGL87_RS04850 (LGL87_04855) 1064596..1064946 + 351 WP_038251290.1 transcriptional regulator -
LGL87_RS04855 (LGL87_04860) 1065021..1066310 + 1290 WP_004720102.1 arsenic transporter -
LGL87_RS04860 (LGL87_04865) 1066323..1066748 + 426 WP_004720103.1 glutaredoxin-dependent arsenate reductase -
LGL87_RS04865 (LGL87_04870) 1067018..1067662 + 645 WP_038243845.1 thermostable hemolysin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-105)

Antitoxin

Antitoxin CbeA

(19-117)


Sequences

Toxin        


Download         Length: 107 a.a.        Molecular weight: 12149.92 Da        Isoelectric Point: 6.0642

>T219023 WP_004720097.1 NZ_CP084650:1062401-1062721 [Yersinia ruckeri]
MQTLPVSPTREAQLGPSPAAVWKQLLTHLFEHHYGLTLNDTPFCYEFVIQEHIESGILLKDAVNFVVERYGLLRIDRSSF
SFDEPSPFINFTDILRARRAIGLMNT

Download         Length: 321 bp

>T219023 NZ_CP116159:c4068389-4068102 [Escherichia coli]
ATGCCAATGGAGTTTGAATGGGATGAAAACAAGGCCAAAAGTAATCGGGTGAAACATGGCATCCGCTTTGAAGATGCGGT
GTTATTGTTTGATGATCCACAACATTTGTCACAGCAAGAACGCATAGAAAACGGTGAGTATCGCTGGCAGACAATCGGCC
TGGTTTACGGCATCGTGGTTATTCTGGTTGCGCATACCATCCGTTTCGAAAGCGGAAATGAAATTATTCGAATCATCAGT
GCACGAAAAGCAGATCGTAAAGAGAGGAATCGCTATGAGCATGGTTAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13456.42 Da        Isoelectric Point: 6.9468

>AT219023 WP_004720095.1 NZ_CP084650:1061958-1062326 [Yersinia ruckeri]
MKPTPSKTIPPKDTTACLQWGLRHDITPCFGARLVQEGQRLHFLADRAGFCGVFSEEGARHLDQAFPLIMKQLELALLSG
ELDPRYQRSITLSHNGLTCEADALGSHGYVYITIYPTPSVTA

Download         Length: 369 bp

>AT219023 NZ_CP116159:c4068115-4067813 [Escherichia coli]
ATGAGCATGGTTAAACATAAACGAGGGACCTCCTCTACACTCGATGTGCAGCATGAGGCCGAACTGAAGGCGCTGACGAA
TAAATCCGACGAAGATATTGATTACAGTGATATCCCACCTTCCAGCGATGAGCAATGGTCTAACGCCGAACGCGGTAAGT
TTTATCGGCCATTGAAAACTCAGGCTTCGGTGCGTATTGATGCTGATGTGATGGAATGGTTGAAGCGACCAGGTAAAGGC
TATCAAACTCGCCTGAACGCAATTTTACGTGAAGCGATGCTGCGCGATCAGAACAAAAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0A8VGU6

Antitoxin

Source ID Structure
AlphaFold DB A0A0A8VB89

References