Detailed information of TA system TA219020

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 3019632..3020301
• Replicon: chromosome
• Accession: NZ_CP084648
• Organism: Yersinia ruckeri strain 17Y0155

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: A0A380QS17
• Locus tag: LGL92_RS13970
• Protein ID: WP_038241020.1
• Coordinates: 3019632..3020054 (-)
• Length: 141 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: -
• Locus tag: LGL92_RS13975
• Protein ID: WP_004719196.1
• Coordinates: 3020035..3020301 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LGL92_RS13950 (LGL92_14000)	3015471..3017204	-	1734	WP_004719191.1	single-stranded-DNA-specific exonuclease RecJ	-
LGL92_RS13955 (LGL92_14005)	3017211..3017927	-	717	WP_004719192.1	bifunctional protein-disulfide isomerase/oxidoreductase DsbC	-
LGL92_RS13960 (LGL92_14010)	3017959..3018858	-	900	WP_004719193.1	site-specific tyrosine recombinase XerD	-
LGL92_RS13965 (LGL92_14015)	3018966..3019484	+	519	WP_038241022.1	flavodoxin FldB	-
LGL92_RS13970 (LGL92_14020)	3019632..3020054	-	423	WP_038241020.1	protein YgfX	Toxin
LGL92_RS13975 (LGL92_14025)	3020035..3020301	-	267	WP_004719196.1	FAD assembly factor SdhE	Antitoxin
LGL92_RS13980 (LGL92_14030)	3020595..3021587	+	993	WP_038241018.1	tRNA-modifying protein YgfZ	-
LGL92_RS13985 (LGL92_14035)	3021726..3022400	-	675	WP_049687854.1	hemolysin III family protein	-
LGL92_RS13990 (LGL92_14040)	3022708..3022964	+	257	Protein_2720	HD domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (2-132)

Antitoxin

• Flavinator of succinate dehydrogenase (7-79)

Sequences

Toxin

Protein

• Length: 141 a.a.
• Molecular weight: 16451.41 Da
• Isoelectric Point: 11.1478

>T219020 WP_038241020.1 NZ_CP084648:c3020054-3019632 [Yersinia ruckeri]
VAQWRCDLRVSWRTQLFSLLVHGVLVLLTLVVPWPDGFTPLWLILLTLVVFECIRSQKNITSRQGEIRLKAGNLLIWKWQ
EWTLVRPPWITRYGVLLSLQGAGSRRRKRIWLASDSMSEEKWRELCLILRHTFDSAAGRE

Nucleotide

• Length: 423 bp

>T219020 NZ_CP116159:3497092-3497310 [Escherichia coli]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10532.09 Da
• Isoelectric Point: 6.7185

>AT219020 WP_004719196.1 NZ_CP084648:c3020301-3020035 [Yersinia ruckeri]
MEIDNKARIHWACRRGMRELDISIMPFFEHEYDTLNDNDKRVFIRLLTSDDPDLFNWLMNHGEPQDSELKRMVKLIQTRN
KARGPVAM

Nucleotide

• Length: 267 bp

>AT219020 NZ_CP116159:3496692-3497066 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTAAACGACCCAACCTCGGGGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Structures

Toxin

• AlphaFold DB: A0A380QS17