Detailed information of TA system TA219011

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /RES-TIGR02293
• Location: 1958517..1959435
• Replicon: chromosome
• Accession: NZ_CP084648
• Organism: Yersinia ruckeri strain 17Y0155

Toxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: LGL92_RS08810
• Protein ID: WP_038242633.1
• Coordinates: 1958977..1959435 (+)
• Length: 153 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: A0A085U7R3
• Locus tag: LGL92_RS08805
• Protein ID: WP_038242631.1
• Coordinates: 1958517..1958963 (+)
• Length: 149 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LGL92_RS08785 (LGL92_08800)	1954215..1954919	+	705	WP_004717543.1	murein tripeptide amidase MpaA	-
LGL92_RS08790 (LGL92_08805)	1954930..1955904	-	975	WP_038251389.1	L-Ala-D/L-Glu epimerase	-
LGL92_RS08795 (LGL92_08810)	1956054..1956557	+	504	WP_004717547.1	thiol peroxidase	-
LGL92_RS08800 (LGL92_08815)	1956592..1958199	-	1608	WP_038251390.1	transcriptional regulator TyrR	-
LGL92_RS08805 (LGL92_08820)	1958517..1958963	+	447	WP_038242631.1	DUF2384 domain-containing protein	Antitoxin
LGL92_RS08810 (LGL92_08825)	1958977..1959435	+	459	WP_038242633.1	RES domain-containing protein	Toxin
LGL92_RS08815 (LGL92_08830)	1959439..1960497	-	1059	WP_038242635.1	YcjF family protein	-
LGL92_RS08820 (LGL92_08835)	1960494..1961891	-	1398	WP_004717556.1	YcjX family protein	-
LGL92_RS08825 (LGL92_08840)	1961872..1962114	-	243	WP_099511574.1	phage shock protein PspD	-
LGL92_RS08830 (LGL92_08845)	1962178..1962537	-	360	WP_004717559.1	envelope stress response membrane protein PspC	-
LGL92_RS08835 (LGL92_08850)	1962537..1962764	-	228	WP_038242637.1	envelope stress response membrane protein PspB	-
LGL92_RS08840 (LGL92_08855)	1962848..1963513	-	666	WP_004717561.1	phage shock protein PspA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (3-147)

Antitoxin

• Antitoxin Xre/MbcA/ParS-like, toxin-binding domain (94-145)

Sequences

Toxin

Protein

• Length: 153 a.a.
• Molecular weight: 17072.55 Da
• Isoelectric Point: 6.6384

>T219011 WP_038242633.1 NZ_CP084648:1958977-1959435 [Yersinia ruckeri]
VMLYRIVHNRYLATAWTGYGAETYGGRWNHKGHAAIYLASSVSLAMLETLVHVEDSATLNDFNLFQITIPDNAIMVLQQQ
DWPRGWRDDPTPVATMDIGTEWIGSVSSVGLLVPSTLVPLERNMLVNPKHRDFASCLKSINPLTFSFDPRLK

Nucleotide

• Length: 459 bp

>T219011 NZ_CP116159:1073944-1074279 [Escherichia coli]
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCTGG
ACATCGTCCAGCTGTTGTCCTGAGTCCTTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTGTACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACAGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTACTGATTGGGTAG

Antitoxin

Protein

• Length: 149 a.a.
• Molecular weight: 16406.87 Da
• Isoelectric Point: 8.0956

>AT219011 WP_038242631.1 NZ_CP084648:1958517-1958963 [Yersinia ruckeri]
MRTYHPSPMAKVSALWREIGLPASRGTALVDSIKLGFTVDVIDTIHLWADMPKSEILRATGIPSRSLTRRRTHDGRFTPE
ESERIARFVRVMDAAVDLFGGDRTKATAWMSMPVKGLGNRTPDSLLETETGALEICDLIGRLEHGVFS

Nucleotide

• Length: 447 bp

>AT219011 NZ_CP116159:1073696-1073944 [Escherichia coli]
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCGGCTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGAGAGCCGAAAGATAAGGAA
GTCTGGTAA

Structures

Antitoxin

• AlphaFold DB: A0A085U7R3