Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) ykfI-yeeU/CbtA-CbeA
Location 1092917..1093680 Replicon chromosome
Accession NZ_CP084648
Organism Yersinia ruckeri strain 17Y0155

Toxin (Protein)


Gene name ykfI Uniprot ID A0A0A8VGU6
Locus tag LGL92_RS04970 Protein ID WP_004720097.1
Coordinates 1093360..1093680 (+) Length 107 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A0A8VB89
Locus tag LGL92_RS04965 Protein ID WP_004720095.1
Coordinates 1092917..1093285 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LGL92_RS04920 (LGL92_04935) 1087944..1088771 + 828 WP_004720076.1 hypothetical protein -
LGL92_RS04925 (LGL92_04940) 1088851..1089732 + 882 WP_230596577.1 50S ribosome-binding GTPase -
LGL92_RS04930 (LGL92_04945) 1089978..1090532 + 555 WP_004720086.1 hypothetical protein -
LGL92_RS04935 (LGL92_04950) 1090535..1091026 + 492 WP_004720088.1 hypothetical protein -
LGL92_RS04940 (LGL92_04955) 1091081..1091437 + 357 WP_004720091.1 hypothetical protein -
LGL92_RS04945 (LGL92_04960) 1091581..1091697 + 117 Protein_958 DUF945 domain-containing protein -
LGL92_RS04950 (LGL92_04965) 1091724..1092176 + 453 WP_004720092.1 antirestriction protein -
LGL92_RS04955 (LGL92_04970) 1092188..1092667 + 480 WP_004720093.1 DNA repair protein RadC -
LGL92_RS04960 (LGL92_04975) 1092671..1092883 + 213 WP_139127562.1 antirestriction protein -
LGL92_RS04965 (LGL92_04980) 1092917..1093285 + 369 WP_004720095.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
LGL92_RS04970 (LGL92_04985) 1093360..1093680 + 321 WP_004720097.1 TA system toxin CbtA family protein Toxin
LGL92_RS04975 (LGL92_04990) 1093798..1094631 + 834 WP_038251289.1 DUF4942 domain-containing protein -
LGL92_RS04980 (LGL92_04995) 1095555..1095905 + 351 WP_038251290.1 transcriptional regulator -
LGL92_RS04985 (LGL92_05000) 1095980..1097269 + 1290 WP_004720102.1 arsenic transporter -
LGL92_RS04990 (LGL92_05005) 1097282..1097707 + 426 WP_004720103.1 glutaredoxin-dependent arsenate reductase -
LGL92_RS04995 (LGL92_05010) 1097977..1098621 + 645 WP_038243845.1 thermostable hemolysin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-105)

Antitoxin

Antitoxin CbeA

(19-117)


Sequences

Toxin        


Download         Length: 107 a.a.        Molecular weight: 12149.92 Da        Isoelectric Point: 6.0642

>T219010 WP_004720097.1 NZ_CP084648:1093360-1093680 [Yersinia ruckeri]
MQTLPVSPTREAQLGPSPAAVWKQLLTHLFEHHYGLTLNDTPFCYEFVIQEHIESGILLKDAVNFVVERYGLLRIDRSSF
SFDEPSPFINFTDILRARRAIGLMNT

Download         Length: 321 bp

>T219010 NZ_CP116159:929593-930000 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCACTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCTGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13456.42 Da        Isoelectric Point: 6.9468

>AT219010 WP_004720095.1 NZ_CP084648:1092917-1093285 [Yersinia ruckeri]
MKPTPSKTIPPKDTTACLQWGLRHDITPCFGARLVQEGQRLHFLADRAGFCGVFSEEGARHLDQAFPLIMKQLELALLSG
ELDPRYQRSITLSHNGLTCEADALGSHGYVYITIYPTPSVTA

Download         Length: 369 bp

>AT219010 NZ_CP116159:929346-929612 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0A8VGU6

Antitoxin

Source ID Structure
AlphaFold DB A0A0A8VB89

References