Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yeeV-yfjZ/CbtA-CbeA |
| Location | 334510..335210 | Replicon | chromosome |
| Accession | NZ_CP084648 | ||
| Organism | Yersinia ruckeri strain 17Y0155 | ||
Toxin (Protein)
| Gene name | yeeV | Uniprot ID | A0A0A8VME3 |
| Locus tag | LGL92_RS01520 | Protein ID | WP_004722495.1 |
| Coordinates | 334854..335210 (-) | Length | 119 a.a. |
Antitoxin (Protein)
| Gene name | yfjZ | Uniprot ID | A0A0A8VG75 |
| Locus tag | LGL92_RS01515 | Protein ID | WP_038251171.1 |
| Coordinates | 334510..334842 (-) | Length | 111 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LGL92_RS01485 (LGL92_01495) | 329610..330740 | + | 1131 | WP_004723068.1 | UDP-N-acetylglucosamine 2-epimerase (non-hydrolyzing) | - |
| LGL92_RS01490 (LGL92_01500) | 330740..331945 | + | 1206 | WP_038251059.1 | glycosyltransferase family 4 protein | - |
| LGL92_RS01495 (LGL92_01505) | 331936..332337 | + | 402 | WP_038241901.1 | WbuC family cupin fold metalloprotein | - |
| LGL92_RS01500 (LGL92_01510) | 332777..333064 | - | 288 | WP_012104592.1 | helix-turn-helix transcriptional regulator | - |
| LGL92_RS01505 (LGL92_01515) | 333051..333374 | - | 324 | WP_004722490.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| LGL92_RS01510 (LGL92_01520) | 333559..334425 | - | 867 | WP_004722491.1 | DUF4942 domain-containing protein | - |
| LGL92_RS01515 (LGL92_01525) | 334510..334842 | - | 333 | WP_038251171.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
| LGL92_RS01520 (LGL92_01530) | 334854..335210 | - | 357 | WP_004722495.1 | TA system toxin CbtA family protein | Toxin |
| LGL92_RS01525 (LGL92_01535) | 335291..335623 | - | 333 | WP_050777623.1 | DUF5983 family protein | - |
| LGL92_RS01530 (LGL92_01540) | 335617..336090 | - | 474 | WP_004722498.1 | DNA repair protein RadC | - |
| LGL92_RS01535 (LGL92_01545) | 336123..336554 | - | 432 | WP_004722500.1 | antirestriction protein | - |
| LGL92_RS01540 (LGL92_01550) | 336916..337737 | - | 822 | WP_038251172.1 | DUF932 domain-containing protein | - |
| LGL92_RS01545 (LGL92_01555) | 338236..338502 | - | 267 | WP_038251173.1 | hypothetical protein | - |
| LGL92_RS01550 (LGL92_01560) | 338642..339133 | - | 492 | WP_230596550.1 | hypothetical protein | - |
| LGL92_RS01555 (LGL92_01565) | 339136..339690 | - | 555 | WP_004722507.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | cap8E | 319602..343934 | 24332 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 119 a.a. Molecular weight: 12999.89 Da Isoelectric Point: 6.4771
>T219008 WP_004722495.1 NZ_CP084648:c335210-334854 [Yersinia ruckeri]
MKPRPTAQGALPVPVIYQQLLAFLLEHHYGLSLNDTPYHDEQAIAQQIEQGISVGDTINALVEKYALVQIGRNGFSALAQ
DPMLSKGDIVRARQASGLWRAHFPPTLLYPTESLNPIP
MKPRPTAQGALPVPVIYQQLLAFLLEHHYGLSLNDTPYHDEQAIAQQIEQGISVGDTINALVEKYALVQIGRNGFSALAQ
DPMLSKGDIVRARQASGLWRAHFPPTLLYPTESLNPIP
Download Length: 357 bp
>T219008 NZ_CP116159:721213-721509 [Escherichia coli]
ATGGAAAAACGCACACCACATACACGTTTGAGTCAGGTTAAAAAACTTGTCAATGCCGGGCAAGTTCGTACAACACGTAG
TGCCCTGTTAAATGCAGATGAGTTAGGTTTGGATTTTGATGGTATGTGTAATGTTATCATTGGATTATCAGAGAGCGACT
TTTATAAAAGCATGACCACCTACTCTGATCATACTATCTGGCAGGATGTTTACAGACCCAGGCTTGTTACAGGCCAGGTT
TATCTTAAAATTACGGTAATTCATGACGTACTGATCGTCTCGTTTAAGGAGAAGTAA
ATGGAAAAACGCACACCACATACACGTTTGAGTCAGGTTAAAAAACTTGTCAATGCCGGGCAAGTTCGTACAACACGTAG
TGCCCTGTTAAATGCAGATGAGTTAGGTTTGGATTTTGATGGTATGTGTAATGTTATCATTGGATTATCAGAGAGCGACT
TTTATAAAAGCATGACCACCTACTCTGATCATACTATCTGGCAGGATGTTTACAGACCCAGGCTTGTTACAGGCCAGGTT
TATCTTAAAATTACGGTAATTCATGACGTACTGATCGTCTCGTTTAAGGAGAAGTAA
Antitoxin
Download Length: 111 a.a. Molecular weight: 12102.74 Da Isoelectric Point: 7.3835
>AT219008 WP_038251171.1 NZ_CP084648:c334842-334510 [Yersinia ruckeri]
MNNHITTSPTWGLKRDITPRLGARLVQEGTHLHFLSDRANIVGTFSPQAAQALDVAFPALITKLESQLLSGQLDPRRQQC
LTVRHGGFVCDADTLGSHGYVYIAVYQELS
MNNHITTSPTWGLKRDITPRLGARLVQEGTHLHFLSDRANIVGTFSPQAAQALDVAFPALITKLESQLLSGQLDPRRQQC
LTVRHGGFVCDADTLGSHGYVYIAVYQELS
Download Length: 333 bp
>AT219008 NZ_CP116159:721511-721906 [Escherichia coli]
ATGAAATGTCCGGTTTGCCACCAGGGAGAAATGGTTTCTGGCATTAAAGATATTCCATACACCTTCCGTGGACGAAAAAC
AGTATTGAAAGGTATCCACGGTTTATATTGTGTCCATTGCGAAGAGAGCATCATGAATAAAGAAGAGTCAGATGCTTTCA
TGGCGCAAGTAAAGGCATTTCGGGCTTCGGTGAATGCCGAAACAGTGGCACCTGAATTTATAGTGAAGGTTCGAAAAAAG
CTCTCTCTTACCCAAAAAGAGGCAAGCGAAATTTTTGGGGGAGGTGTAAATGCGTTTTCGCGTTACGAAAAAGGCAATGC
CCAACCTCATCCTTCCACAATCAAACTTTTACGTGTTCTGGATAAGCATCCAGAACTATTGAATGAAATCCGTTAA
ATGAAATGTCCGGTTTGCCACCAGGGAGAAATGGTTTCTGGCATTAAAGATATTCCATACACCTTCCGTGGACGAAAAAC
AGTATTGAAAGGTATCCACGGTTTATATTGTGTCCATTGCGAAGAGAGCATCATGAATAAAGAAGAGTCAGATGCTTTCA
TGGCGCAAGTAAAGGCATTTCGGGCTTCGGTGAATGCCGAAACAGTGGCACCTGAATTTATAGTGAAGGTTCGAAAAAAG
CTCTCTCTTACCCAAAAAGAGGCAAGCGAAATTTTTGGGGGAGGTGTAAATGCGTTTTCGCGTTACGAAAAAGGCAATGC
CCAACCTCATCCTTCCACAATCAAACTTTTACGTGTTCTGGATAAGCATCCAGAACTATTGAATGAAATCCGTTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0A8VME3 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0A8VG75 |