Detailed information of TA system TA219006

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 2869357..2870026
• Replicon: chromosome
• Accession: NZ_CP084647
• Organism: Yersinia ruckeri strain 17Y0157

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: A0A380QS17
• Locus tag: LGL89_RS12995
• Protein ID: WP_038241020.1
• Coordinates: 2869357..2869779 (-)
• Length: 141 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: -
• Locus tag: LGL89_RS13000
• Protein ID: WP_004719196.1
• Coordinates: 2869760..2870026 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LGL89_RS12975 (LGL89_13020)	2865196..2866929	-	1734	WP_038276198.1	single-stranded-DNA-specific exonuclease RecJ	-
LGL89_RS12980 (LGL89_13025)	2866936..2867652	-	717	WP_234054756.1	bifunctional protein-disulfide isomerase/oxidoreductase DsbC	-
LGL89_RS12985 (LGL89_13030)	2867684..2868583	-	900	WP_004719193.1	site-specific tyrosine recombinase XerD	-
LGL89_RS12990 (LGL89_13035)	2868691..2869209	+	519	WP_038241022.1	flavodoxin FldB	-
LGL89_RS12995 (LGL89_13040)	2869357..2869779	-	423	WP_038241020.1	protein YgfX	Toxin
LGL89_RS13000 (LGL89_13045)	2869760..2870026	-	267	WP_004719196.1	FAD assembly factor SdhE	Antitoxin
LGL89_RS13005 (LGL89_13050)	2870320..2871312	+	993	WP_038241018.1	tRNA-modifying protein YgfZ	-
LGL89_RS13010 (LGL89_13055)	2871451..2872116	-	666	WP_175537887.1	hemolysin III family protein	-
LGL89_RS13015 (LGL89_13060)	2872433..2872689	+	257	Protein_2524	HD domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (2-132)

Antitoxin

• Flavinator of succinate dehydrogenase (7-79)

Sequences

Toxin

Protein

• Length: 141 a.a.
• Molecular weight: 16451.41 Da
• Isoelectric Point: 11.1478

>T219006 WP_038241020.1 NZ_CP084647:c2869779-2869357 [Yersinia ruckeri]
VAQWRCDLRVSWRTQLFSLLVHGVLVLLTLVVPWPDGFTPLWLILLTLVVFECIRSQKNITSRQGEIRLKAGNLLIWKWQ
EWTLVRPPWITRYGVLLSLQGAGSRRRKRIWLASDSMSEEKWRELCLILRHTFDSAAGRE

Nucleotide

• Length: 423 bp

>T219006 NZ_CP116159:c611913-611449 [Escherichia coli]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGACGCTTTAGTTGC
CGAAGTCGAGACATTAAAGGGAAAAGTTCCTGAAAATTATCAGAGAAAAGCCGCCACAAAGTTATTGGCGGTAGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGTTATCGTCTCTTCTTTCGTTATAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACTCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGCAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAACCCTCACCCGAGAAACAGAAGAAACCCATTGA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10532.09 Da
• Isoelectric Point: 6.7185

>AT219006 WP_004719196.1 NZ_CP084647:c2870026-2869760 [Yersinia ruckeri]
MEIDNKARIHWACRRGMRELDISIMPFFEHEYDTLNDNDKRVFIRLLTSDDPDLFNWLMNHGEPQDSELKRMVKLIQTRN
KARGPVAM

Nucleotide

• Length: 267 bp

>AT219006 NZ_CP116159:c612248-611913 [Escherichia coli]
ATGCCCGCTAATGCTCGCTCTCACGCTGTACTGACCACTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCAGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTATTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCAACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA

Structures

Toxin

• AlphaFold DB: A0A380QS17