218995

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 948832..949455 Replicon chromosome
Accession NZ_CP084647
Organism Yersinia ruckeri strain 17Y0157

Toxin (Protein)


Gene name Hha Uniprot ID A0A085U5C4
Locus tag LGL89_RS04260 Protein ID WP_038243726.1
Coordinates 948832..949035 (-) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A085U5C5
Locus tag LGL89_RS04265 Protein ID WP_004718732.1
Coordinates 949087..949455 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LGL89_RS04235 (LGL89_04250) 944687..945025 + 339 WP_007886947.1 P-II family nitrogen regulator -
LGL89_RS04240 (LGL89_04255) 945064..946352 + 1289 Protein_819 ammonium transporter AmtB -
LGL89_RS04245 (LGL89_04260) 946467..947330 - 864 WP_004718726.1 acyl-CoA thioesterase II -
LGL89_RS04250 (LGL89_04265) 947708..948022 - 315 WP_071706550.1 MGMT family protein -
LGL89_RS04260 (LGL89_04275) 948832..949035 - 204 WP_038243726.1 expression modulating protein YmoA Toxin
LGL89_RS04265 (LGL89_04280) 949087..949455 - 369 WP_004718732.1 Hha toxicity modulator TomB Antitoxin
LGL89_RS04270 (LGL89_04285) 950504..950665 + 162 WP_004718735.1 hypothetical protein -
LGL89_RS04275 (LGL89_04290) 950784..950927 - 144 WP_004718738.1 type B 50S ribosomal protein L36 -
LGL89_RS04280 (LGL89_04295) 950947..951201 - 255 WP_038243728.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8037.27 Da        Isoelectric Point: 6.4573

>T218995 WP_038243726.1 NZ_CP084647:c949035-948832 [Yersinia ruckeri]
MTKTDYLMRLRKCTTIDTLERVIEKNKYELSDDELELFYSAADHRLAELTMNKLYDKIPATVWQHVK

Download         Length: 204 bp

>T218995 NZ_CP116152:c3619252-3618854 [Escherichia coli]
ATGCGGGTATTCAAAACAAAACTTATTCGCCTGCAACTTACAGCAGAGGAACTTGATGCGTTAACGGCGGATTTTATTTC
CTATAAGCGTGACGGTGTTTTGCCAGATATATTTGGTCGCGATGCACTCTACGACGACTCGTTTACCTGGCCATTAATCA
AATTTGAGCGAGTTGCTCATATTCATCTGGCAAATGTGAATAATCCATTTCCGCCACAGTTGCGCCAATTCAGCAGAACG
AATGACGAAGCGCATTTGGTATATTGTCAGGGTGCGTTTGATGAGCAAGCATGGTTGCTCATTGCCATTCTGAAACCTGA
ACCTCATAAACAGGCTCGAGATAACAACCAAATGCATAAAATTGGGAAAATGGCAGAAGCGTTTCGCATGCGTTTTTGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14277.08 Da        Isoelectric Point: 4.4225

>AT218995 WP_004718732.1 NZ_CP084647:c949455-949087 [Yersinia ruckeri]
MDEYSPKRHDIAQLKFLCENLYDEGIATLGDSHHGWVNDPTSAVNLQLNDLIEHIASFVMSFKIKYADEIDLCELVEEYL
DDTYTLFSSYGINDPDLRRWQKTKDRLFRLFSGEYLCALMKN

Download         Length: 369 bp

>AT218995 NZ_CP116152:c3619548-3619255 [Escherichia coli]
ATGCATCGAATTCTCGCTGAAAAATCGGTCAATATTACTGAGTTACGTAAAAACCCAGCTAAATACTTTATTGATCAACC
GGTTGCGGTTCTTTCTAATAATCGCCCCGCAGGATATCTCTTAAGTGCCAGCGCATTCGAAGCGTTAATGGACATGCTTG
CTGAACAAGAGGAGAAAAAGCCCATAAAGGCGCGCTTCCGTCCAAGTGCTGCAAGATTAGAGGAAATTACACGCCGAGCT
GAAAAATATCTTAATGATATGACGGATGATGATTTCAATGACTTTAAGGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A085U5C4

Antitoxin

Source ID Structure
AlphaFold DB A0A085U5C5

References