218993

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pmenTA/darT(toxin)
Location 455120..456840 Replicon chromosome
Accession NZ_CP084647
Organism Yersinia ruckeri strain 17Y0157

Toxin (Protein)


Gene name pmenT Uniprot ID -
Locus tag LGL89_RS02055 Protein ID WP_096823271.1
Coordinates 455120..455776 (+) Length 219 a.a.

Antitoxin (Protein)


Gene name pmenA Uniprot ID -
Locus tag LGL89_RS02060 Protein ID WP_038245756.1
Coordinates 455773..456840 (+) Length 356 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LGL89_RS02030 (LGL89_02040) 452683..453057 + 375 Protein_392 tyrosine-type recombinase/integrase -
LGL89_RS02035 (LGL89_02045) 453231..453485 + 255 WP_005175264.1 type II toxin-antitoxin system RelB/DinJ family antitoxin -
LGL89_RS02040 (LGL89_02050) 453475..453765 + 291 WP_038275268.1 type II toxin-antitoxin system RelE/ParE family toxin -
LGL89_RS02045 (LGL89_02055) 454029..454418 + 390 WP_096823270.1 restriction endonuclease subunit S -
LGL89_RS02050 (LGL89_02060) 454542..455117 + 576 WP_234049239.1 DarT ssDNA thymidine ADP-ribosyltransferase family protein -
LGL89_RS02055 (LGL89_02065) 455120..455776 + 657 WP_096823271.1 DUF4433 domain-containing protein Toxin
LGL89_RS02060 (LGL89_02070) 455773..456840 + 1068 WP_038245756.1 macro domain-containing protein Antitoxin
LGL89_RS02065 (LGL89_02075) 456861..457127 + 267 Protein_399 hypothetical protein -
LGL89_RS02070 (LGL89_02080) 457146..457544 - 399 Protein_400 integrase core domain-containing protein -
LGL89_RS02075 (LGL89_02085) 457543..457839 + 297 Protein_401 integrase core domain-containing protein -
LGL89_RS02080 (LGL89_02090) 457868..457973 - 106 Protein_402 transposase -
LGL89_RS02085 (LGL89_02095) 457987..458115 - 129 Protein_403 helix-turn-helix domain-containing protein -
LGL89_RS02090 (LGL89_02100) 458265..458495 + 231 Protein_404 DUF4942 domain-containing protein -
LGL89_RS02095 (LGL89_02105) 458570..458965 + 396 WP_038245317.1 DUF6088 family protein -
LGL89_RS02100 (LGL89_02110) 458958..459908 + 951 WP_038275283.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein -
LGL89_RS02105 (LGL89_02115) 460279..460404 + 126 Protein_407 antirestriction protein -
LGL89_RS02110 (LGL89_02120) 460430..460603 + 174 Protein_408 type IV toxin-antitoxin system YeeU family antitoxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 440574..456840 16266
- flank IS/Tn - - 457591..457839 248


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

ssDNA thymidine ADP-ribosyltransferase, DarT

(17-217)

Antitoxin

Macro domain

(18-129)


Sequences

Toxin        


Download         Length: 219 a.a.        Molecular weight: 25214.72 Da        Isoelectric Point: 6.6007

>T218993 WP_096823271.1 NZ_CP084647:455120-455776 [Yersinia ruckeri]
VAYDYSTSLNPEKALIWRIVHRDNIPWILDNGLHCGNSPVQAEDWINIGNPELIDKRAGHLVPTGMRGTLHDYVPFYFTP
FSPMLMNIRSGRGGIKQRPNEEIVILVSSLRNMVAQNVSFVFTDSHAYYNLANYFTELDSLNQIDWPILQARDFRRDQDD
LAKFERYQAEALIWKHCPIALLGGMICYNDGVRLQLEQWLSQRNLSMPVHARAGWYFS

Download         Length: 657 bp

>T218993 NZ_CP116152:2580123-2580230 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCGGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 356 a.a.        Molecular weight: 40846.27 Da        Isoelectric Point: 6.6976

>AT218993 WP_038245756.1 NZ_CP084647:455773-456840 [Yersinia ruckeri]
MITFTQGNLLDAPVEALVNTVNTVGVMGKGIALMFKERFPVNMKAYALACKHKQVMTGKMFITETGELMGPRWIVNFPTK
QHWRADSRMEWVEDGLQDLRRFLIKEKVQSIAIPPLGAGNGGLNWSDVRMRIESALGDLQDTEILIYEPTEKYQNVAKST
GVKKLTPARALIAELVRRYWVLGMECSLLEIQKLAWLLQRAIEQHQQEDVLKLRFEAHYYGPYAPNLNHLLNALDGTYLK
AEKRIPDTQPLDVIWFNDQEKEHINLWLNNEAKEWLPALEQVSQLIDGFESPFGLELLATVDWLLTRGKCQPTLDSVKEG
LHQWPAGERWASRKMKLFDDKNLQFAINRVMEFHC

Download         Length: 1068 bp

>AT218993 NZ_CP116152:c2580076-2580010 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References