Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/Txe-YefM
Location 3758328..3758857 Replicon chromosome
Accession NC_008769
Organism Mycobacterium bovis BCG str. Pasteur 1173P2

Toxin (Protein)


Gene name relE Uniprot ID G0TI95
Locus tag BCG_RS17625 Protein ID WP_003417760.1
Coordinates 3758600..3758857 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID G0TI94
Locus tag BCG_RS17620 Protein ID WP_003417757.1
Coordinates 3758328..3758603 (+) Length 92 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BCG_RS17585 3753359..3754657 - 1299 WP_011799343.1 PPE family protein -
BCG_RS22605 3755126..3756563 - 1438 Protein_3441 FAD-binding oxidoreductase -
BCG_RS17605 3756666..3757055 + 390 WP_010950876.1 DUF732 domain-containing protein -
BCG_RS17610 3757069..3757362 - 294 WP_003417749.1 DUF3017 domain-containing protein -
BCG_RS17615 3757359..3758204 - 846 WP_010950877.1 bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase -
BCG_RS17620 3758328..3758603 + 276 WP_003417757.1 type II toxin-antitoxin system antitoxin RelJ Antitoxin
BCG_RS17625 3758600..3758857 + 258 WP_003417760.1 Txe/YoeB family addiction module toxin Toxin
BCG_RS17630 3758899..3760089 + 1191 WP_003900033.1 NADH:flavin oxidoreductase -
BCG_RS17635 3760206..3760574 + 369 WP_003417765.1 FHA domain-containing protein -
BCG_RS17640 3760571..3761122 - 552 WP_003417767.1 pentapeptide repeat protein MfpA -
BCG_RS17645 3761129..3761710 - 582 WP_003417769.1 ATP/GTP-binding protein -
BCG_RS17650 3761691..3762059 - 369 WP_003417772.1 DUF742 domain-containing protein -
BCG_RS17655 3762037..3762429 - 393 WP_011799344.1 roadblock/LC7 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(6-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(2-72)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10070.30 Da        Isoelectric Point: 6.4693

>T21899 WP_003417760.1 NC_008769:3758600-3758857 [Mycobacterium tuberculosis variant bovis BCG str. Pasteur 1173P2]
VRSVNFDPDAWEDFLFWLAADRKTARRITRLIGEIQRDPFSGIGKPEPLQGELSGYWSRRIDDEHRLVYRAGDDEVTMLK
ARYHY

Download         Length: 258 bp

>T21899 NC_008769:3758600-3758857 [Mycobacterium tuberculosis variant bovis BCG str. Pasteur 1173P2]
GTGAGAAGCGTCAACTTCGATCCCGATGCCTGGGAGGACTTCTTGTTCTGGCTGGCCGCTGATCGCAAAACGGCCCGTCG
GATCACCCGGTTGATCGGAGAAATTCAGCGTGATCCGTTCAGCGGGATCGGCAAACCCGAGCCGCTCCAAGGTGAGTTGT
CGGGATACTGGTCGCGCCGGATCGACGACGAACACCGGCTAGTGTATCGAGCGGGCGACGACGAAGTCACGATGCTGAAG
GCCCGATACCACTACTGA

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 10194.35 Da        Isoelectric Point: 4.6652

>AT21899 WP_003417757.1 NC_008769:3758328-3758603 [Mycobacterium tuberculosis variant bovis BCG str. Pasteur 1173P2]
MSISASEARQRLFPLIEQVNTDHQPVRITSRAGDAVLMSADDYDAWQETVYLLRSPENARRLMEAVARDKAGHSAFTKSV
DELREMAGGEE

Download         Length: 276 bp

>AT21899 NC_008769:3758328-3758603 [Mycobacterium tuberculosis variant bovis BCG str. Pasteur 1173P2]
ATGAGCATCAGTGCGAGCGAGGCGAGGCAGCGCCTGTTTCCACTCATCGAACAGGTCAATACCGATCACCAGCCGGTGCG
GATCACCTCCCGGGCCGGCGATGCGGTGCTGATGTCCGCCGACGACTACGACGCGTGGCAGGAAACGGTCTATCTGCTGC
GCTCACCGGAGAACGCCAGGCGGTTGATGGAAGCGGTTGCCCGGGATAAGGCTGGGCACTCGGCTTTCACCAAGTCTGTA
GATGAGCTGCGGGAGATGGCCGGCGGCGAGGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3OEI

Antitoxin

Source ID Structure
PDB 3CTO
PDB 3OEI
PDB 3D55
AlphaFold DB G0TI94

References