Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumA-relB/upstrm_HI1419-dnstrm_HI1420
Location 45266..45848 Replicon plasmid p17Y0159.1
Accession NZ_CP084644
Organism Yersinia ruckeri strain 17Y0159

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag LGL91_RS17810 Protein ID WP_234057223.1
Coordinates 45266..45562 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag LGL91_RS17815 Protein ID WP_234057224.1
Coordinates 45564..45848 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LGL91_RS17775 (LGL91_17825) 40449..41003 + 555 Protein_56 ISAs1 family transposase -
LGL91_RS17780 (LGL91_17830) 41046..42246 + 1201 Protein_57 IS3 family transposase -
LGL91_RS17785 (LGL91_17835) 42486..43037 - 552 WP_265099274.1 IS110 family transposase -
LGL91_RS17795 (LGL91_17845) 44278..44757 - 480 Protein_60 IS110 family transposase -
LGL91_RS17800 (LGL91_17850) 44830..44931 - 102 Protein_61 IS6 family transposase -
LGL91_RS17805 (LGL91_17855) 44973..45194 + 222 WP_234057222.1 ProQ/FINO family protein -
LGL91_RS17810 (LGL91_17860) 45266..45562 + 297 WP_234057223.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LGL91_RS17815 (LGL91_17865) 45564..45848 + 285 WP_234057224.1 putative addiction module antidote protein Antitoxin
LGL91_RS17820 (LGL91_17870) 45903..46592 - 690 WP_234057225.1 IS6 family transposase -
LGL91_RS17825 (LGL91_17875) 47312..49066 + 1755 WP_234057226.1 ShlB/FhaC/HecB family hemolysin secretion/activation protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..85059 85059


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(3-96)

Antitoxin

Uncharacterized protein HI1420

(5-90)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11334.30 Da        Isoelectric Point: 10.2781

>T218989 WP_234057223.1 NZ_CP084644:45266-45562 [Yersinia ruckeri]
MIEIRRTLEVEKWLKSLKDRMAKAKILMRIERMEEGHFGDVEAIGNGLSELRIHQGKGYRLYFGNKNNQVILLLCGGDKS
TQQEDIKKAKLLATKWGF

Download         Length: 297 bp

>T218989 NZ_CP116152:1965831-1965934 [Escherichia coli]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10502.87 Da        Isoelectric Point: 4.6794

>AT218989 WP_234057224.1 NZ_CP084644:45564-45848 [Yersinia ruckeri]
MNNELKKFDVVEFLDDEEDIQEYLNAAIEEDDAKYLFKALGNIARARNMSQLSKEVGMSREGIYKALSGEGNPSFQTVSK
ITKALGLKLHFTGA

Download         Length: 285 bp

>AT218989 NZ_CP116152:c1965972-1965701 [Escherichia coli]
AAAGTCAGCGAAGGAAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGCGGTGGTCATCAGCTTAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References