Detailed information of TA system TA218987

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 3037926..3038595
• Replicon: chromosome
• Accession: NZ_CP084643
• Organism: Yersinia ruckeri strain 17Y0159

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: A0A380QS17
• Locus tag: LGL91_RS14140
• Protein ID: WP_038241020.1
• Coordinates: 3037926..3038348 (-)
• Length: 141 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: -
• Locus tag: LGL91_RS14145
• Protein ID: WP_004719196.1
• Coordinates: 3038329..3038595 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LGL91_RS14120 (LGL91_14165)	3033765..3035498	-	1734	WP_038276198.1	single-stranded-DNA-specific exonuclease RecJ	-
LGL91_RS14125 (LGL91_14170)	3035505..3036221	-	717	WP_004719192.1	bifunctional protein-disulfide isomerase/oxidoreductase DsbC	-
LGL91_RS14130 (LGL91_14175)	3036253..3037152	-	900	WP_004719193.1	site-specific tyrosine recombinase XerD	-
LGL91_RS14135 (LGL91_14180)	3037260..3037778	+	519	WP_038241022.1	flavodoxin FldB	-
LGL91_RS14140 (LGL91_14185)	3037926..3038348	-	423	WP_038241020.1	protein YgfX	Toxin
LGL91_RS14145 (LGL91_14190)	3038329..3038595	-	267	WP_004719196.1	FAD assembly factor SdhE	Antitoxin
LGL91_RS14150 (LGL91_14195)	3038889..3039881	+	993	WP_038241018.1	tRNA-modifying protein YgfZ	-
LGL91_RS14155 (LGL91_14200)	3040020..3040685	-	666	WP_175537887.1	hemolysin III family protein	-
LGL91_RS14160 (LGL91_14205)	3041002..3041258	+	257	Protein_2739	HD domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (2-132)

Antitoxin

• Flavinator of succinate dehydrogenase (7-79)

Sequences

Toxin

Protein

• Length: 141 a.a.
• Molecular weight: 16451.41 Da
• Isoelectric Point: 11.1478

>T218987 WP_038241020.1 NZ_CP084643:c3038348-3037926 [Yersinia ruckeri]
VAQWRCDLRVSWRTQLFSLLVHGVLVLLTLVVPWPDGFTPLWLILLTLVVFECIRSQKNITSRQGEIRLKAGNLLIWKWQ
EWTLVRPPWITRYGVLLSLQGAGSRRRKRIWLASDSMSEEKWRELCLILRHTFDSAAGRE

Nucleotide

• Length: 423 bp

>T218987 NZ_CP116152:844950-845357 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCACTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCTGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10532.09 Da
• Isoelectric Point: 6.7185

>AT218987 WP_004719196.1 NZ_CP084643:c3038595-3038329 [Yersinia ruckeri]
MEIDNKARIHWACRRGMRELDISIMPFFEHEYDTLNDNDKRVFIRLLTSDDPDLFNWLMNHGEPQDSELKRMVKLIQTRN
KARGPVAM

Nucleotide

• Length: 267 bp

>AT218987 NZ_CP116152:844703-844969 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Structures

Toxin

• AlphaFold DB: A0A380QS17