Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 958549..959172 Replicon chromosome
Accession NZ_CP084643
Organism Yersinia ruckeri strain 17Y0159

Toxin (Protein)


Gene name Hha Uniprot ID A0A085U5C4
Locus tag LGL91_RS04300 Protein ID WP_038243726.1
Coordinates 958549..958752 (-) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A085U5C5
Locus tag LGL91_RS04305 Protein ID WP_004718732.1
Coordinates 958804..959172 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LGL91_RS04275 (LGL91_04290) 954404..954742 + 339 WP_007886947.1 P-II family nitrogen regulator -
LGL91_RS04280 (LGL91_04295) 954781..956070 + 1290 WP_234055581.1 ammonium transporter AmtB -
LGL91_RS04285 (LGL91_04300) 956185..957048 - 864 WP_004718726.1 acyl-CoA thioesterase II -
LGL91_RS04290 (LGL91_04305) 957426..957740 - 315 WP_004718728.1 MGMT family protein -
LGL91_RS04300 (LGL91_04315) 958549..958752 - 204 WP_038243726.1 expression modulating protein YmoA Toxin
LGL91_RS04305 (LGL91_04320) 958804..959172 - 369 WP_004718732.1 Hha toxicity modulator TomB Antitoxin
LGL91_RS04310 (LGL91_04325) 960245..960382 + 138 WP_186368427.1 hypothetical protein -
LGL91_RS04315 (LGL91_04330) 960501..960644 - 144 WP_004718738.1 type B 50S ribosomal protein L36 -
LGL91_RS04320 (LGL91_04335) 960664..960918 - 255 WP_038243728.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8037.27 Da        Isoelectric Point: 6.4573

>T218977 WP_038243726.1 NZ_CP084643:c958752-958549 [Yersinia ruckeri]
MTKTDYLMRLRKCTTIDTLERVIEKNKYELSDDELELFYSAADHRLAELTMNKLYDKIPATVWQHVK

Download         Length: 204 bp

>T218977 NZ_CP116145:4055475-4055777 [Escherichia coli]
ATGGCTCAAAAGAAAAATATAAGGAGTTTTCGTGATGCCTGGTTGGCTGATTTTTTTGTCCATTCAACGCCACATCGAAA
GATCCCTGCTGAAATCCATACCACGTTATCACGAAAGTTGGACATCATTAATGCTGCCACTTCTCATCGGGATTTACGCT
CCCCTCCGGGGAACCGATACGAAGAGTTATCCGGGAAATTACAGGAATACTCCTCCATTAGAGTGAATAAACAGTACCGA
CTGATTTTTAAATGGGTTAATGGCAAGGCCGAAGAATTGTTTTTAGACCCACACAACTACTAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14277.08 Da        Isoelectric Point: 4.4225

>AT218977 WP_004718732.1 NZ_CP084643:c959172-958804 [Yersinia ruckeri]
MDEYSPKRHDIAQLKFLCENLYDEGIATLGDSHHGWVNDPTSAVNLQLNDLIEHIASFVMSFKIKYADEIDLCELVEEYL
DDTYTLFSSYGINDPDLRRWQKTKDRLFRLFSGEYLCALMKN

Download         Length: 369 bp

>AT218977 NZ_CP116145:4055813-4056154 [Escherichia coli]
ATGAAACAGGCAACAAGAAAACCGACGACACCCGGAGATATTCTTCTCTATGAATATCTGGAACCGCTCGATTTGAAAAT
CAATGAGTTAGCAGAGTTGCTGCATGTTCATCGTAATAGCGTCAGTGCACTGATCAATAACAATCGTAAACTCACCACTG
AGATGGCATTCCGTCTGGCGAAAGTTTTTGATACCACAGTCGATTTTTGGCTAAACCTCCAGGCGGCAGTTGATCTTTGG
GAAGTTGAAAACAACATGCGTACCCAGGAAGAATTGGGACGGATTGAAACAGTGGCTGAATATTTGGCACGCCGTGAAGA
GCGTGCAAAAAAGGTCGCGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A085U5C4

Antitoxin

Source ID Structure
AlphaFold DB A0A085U5C5

References