Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | sanaTA/AbiEii-DUF6088 |
| Location | 468952..470290 | Replicon | chromosome |
| Accession | NZ_CP084643 | ||
| Organism | Yersinia ruckeri strain 17Y0159 | ||
Toxin (Protein)
| Gene name | sanaT | Uniprot ID | - |
| Locus tag | LGL91_RS02185 | Protein ID | WP_234055605.1 |
| Coordinates | 469340..470290 (+) | Length | 317 a.a. |
Antitoxin (Protein)
| Gene name | sanaA | Uniprot ID | A0A848MNT5 |
| Locus tag | LGL91_RS02180 | Protein ID | WP_038245317.1 |
| Coordinates | 468952..469347 (+) | Length | 132 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LGL91_RS02130 (LGL91_02145) | 464417..464806 | + | 390 | WP_234056964.1 | restriction endonuclease subunit S | - |
| LGL91_RS02135 (LGL91_02150) | 464930..465505 | + | 576 | WP_234049239.1 | DarT ssDNA thymidine ADP-ribosyltransferase family protein | - |
| LGL91_RS02140 (LGL91_02155) | 465508..466164 | + | 657 | WP_096823271.1 | DUF4433 domain-containing protein | - |
| LGL91_RS02145 (LGL91_02160) | 466161..467228 | + | 1068 | WP_096823272.1 | macro domain-containing protein | - |
| LGL91_RS02150 (LGL91_02165) | 467249..467515 | + | 267 | Protein_407 | hypothetical protein | - |
| LGL91_RS02155 (LGL91_02170) | 467534..467932 | - | 399 | Protein_408 | integrase core domain-containing protein | - |
| LGL91_RS02160 (LGL91_02175) | 467931..468227 | + | 297 | Protein_409 | integrase core domain-containing protein | - |
| LGL91_RS02165 (LGL91_02180) | 468256..468376 | - | 121 | Protein_410 | transposase | - |
| LGL91_RS02170 (LGL91_02185) | 468369..468497 | - | 129 | Protein_411 | helix-turn-helix domain-containing protein | - |
| LGL91_RS02175 (LGL91_02190) | 468647..468877 | + | 231 | Protein_412 | DUF4942 domain-containing protein | - |
| LGL91_RS02180 (LGL91_02195) | 468952..469347 | + | 396 | WP_038245317.1 | DUF6088 family protein | Antitoxin |
| LGL91_RS02185 (LGL91_02200) | 469340..470290 | + | 951 | WP_234055605.1 | nucleotidyl transferase AbiEii/AbiGii toxin family protein | Toxin |
| LGL91_RS02190 (LGL91_02205) | 470694..470819 | + | 126 | Protein_415 | antirestriction protein | - |
| LGL91_RS02195 (LGL91_02210) | 470845..471018 | + | 174 | Protein_416 | type IV toxin-antitoxin system YeeU family antitoxin | - |
| LGL91_RS02200 (LGL91_02215) | 471621..472775 | + | 1155 | WP_038245380.1 | N-acetylneuraminate epimerase | - |
| LGL91_RS02205 (LGL91_02220) | 472823..473515 | + | 693 | WP_038245321.1 | oligogalacturonate-specific porin KdgM family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | flank | IS/Tn | - | - | 467979..468227 | 248 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 317 a.a. Molecular weight: 36013.34 Da Isoelectric Point: 4.5092
>T218976 WP_234055605.1 NZ_CP084643:469340-470290 [Yersinia ruckeri]
MDDLTKLFPDVADALGIESVSIVEKDYYIVELLRLLQPMDFDTHQLVFAGGTALSKAGISLNRMSEDVDIKLVPLAGFSQ
QYSRGQRKSIRKGIIQTIIETVAASGTFLLDEEYPKVTRDEYRYNEIPVRYPQEYVQVPCLRPFIKLELMETDLLEAAEN
RAISSLVMDLTKKGEVVRAFPCATIGSTQAEKLISMMRRTAASMRDVERAVDESLVRHIYDNFCIVREKGADVPVLKQFV
QECIEQDIERYGAQYPEFCESPVEELKMGLEELVSNPVYKERYLQFVTPMVFGESHVSWEEAYACFRKTVLDVVDA
MDDLTKLFPDVADALGIESVSIVEKDYYIVELLRLLQPMDFDTHQLVFAGGTALSKAGISLNRMSEDVDIKLVPLAGFSQ
QYSRGQRKSIRKGIIQTIIETVAASGTFLLDEEYPKVTRDEYRYNEIPVRYPQEYVQVPCLRPFIKLELMETDLLEAAEN
RAISSLVMDLTKKGEVVRAFPCATIGSTQAEKLISMMRRTAASMRDVERAVDESLVRHIYDNFCIVREKGADVPVLKQFV
QECIEQDIERYGAQYPEFCESPVEELKMGLEELVSNPVYKERYLQFVTPMVFGESHVSWEEAYACFRKTVLDVVDA
Download Length: 951 bp
>T218976 NZ_CP116145:c4026521-4026303 [Escherichia coli]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA
Antitoxin
Download Length: 132 a.a. Molecular weight: 14406.76 Da Isoelectric Point: 11.0360
>AT218976 WP_038245317.1 NZ_CP084643:468952-469347 [Yersinia ruckeri]
MTTKARIQLRLKRSKRYVFTRDDFKDLAGYDQIGRALRELVKEGQLLKVGYGVYTKARQNVITGKLMPAAPGGSAAVVIE
ALERLKVDYRLVGATSAYNSGKSTQIPASLEIKTSPRFKRTLSVGSSKLNG
MTTKARIQLRLKRSKRYVFTRDDFKDLAGYDQIGRALRELVKEGQLLKVGYGVYTKARQNVITGKLMPAAPGGSAAVVIE
ALERLKVDYRLVGATSAYNSGKSTQIPASLEIKTSPRFKRTLSVGSSKLNG
Download Length: 396 bp
>AT218976 NZ_CP116145:c4026921-4026547 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTTAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTTAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|