Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-RelB |
| Location | 3181981..3182515 | Replicon | chromosome |
| Accession | NZ_CP084642 | ||
| Organism | Yersinia ruckeri strain 17Y0161 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | A0A0T9LYG3 |
| Locus tag | LGL90_RS14530 | Protein ID | WP_038275268.1 |
| Coordinates | 3181981..3182271 (-) | Length | 97 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | A1JJ37 |
| Locus tag | LGL90_RS14535 | Protein ID | WP_005175264.1 |
| Coordinates | 3182261..3182515 (-) | Length | 85 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LGL90_RS14480 (LGL90_14510) | 3177237..3177467 | - | 231 | Protein_2806 | DUF4942 domain-containing protein | - |
| LGL90_RS14485 (LGL90_14515) | 3177617..3177745 | + | 129 | Protein_2807 | helix-turn-helix domain-containing protein | - |
| LGL90_RS14490 (LGL90_14520) | 3177738..3177858 | + | 121 | Protein_2808 | transposase | - |
| LGL90_RS14495 (LGL90_14525) | 3177887..3178183 | - | 297 | Protein_2809 | integrase core domain-containing protein | - |
| LGL90_RS14500 (LGL90_14530) | 3178182..3178580 | + | 399 | Protein_2810 | integrase core domain-containing protein | - |
| LGL90_RS14505 (LGL90_14535) | 3178599..3178885 | - | 287 | Protein_2811 | hypothetical protein | - |
| LGL90_RS14510 (LGL90_14540) | 3178906..3179973 | - | 1068 | WP_038245756.1 | macro domain-containing protein | - |
| LGL90_RS14515 (LGL90_14545) | 3179970..3180626 | - | 657 | WP_096823271.1 | DUF4433 domain-containing protein | - |
| LGL90_RS14520 (LGL90_14550) | 3180629..3181204 | - | 576 | WP_234049239.1 | DarT ssDNA thymidine ADP-ribosyltransferase family protein | - |
| LGL90_RS14525 (LGL90_14555) | 3181328..3181717 | - | 390 | WP_234049240.1 | restriction endonuclease subunit S | - |
| LGL90_RS14530 (LGL90_14560) | 3181981..3182271 | - | 291 | WP_038275268.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| LGL90_RS14535 (LGL90_14565) | 3182261..3182515 | - | 255 | WP_005175264.1 | type II toxin-antitoxin system RelB/DinJ family antitoxin | Antitoxin |
| LGL90_RS14545 (LGL90_14575) | 3183904..3185088 | - | 1185 | WP_234049241.1 | integrase arm-type DNA-binding domain-containing protein | - |
| LGL90_RS14555 (LGL90_14585) | 3185475..3186545 | - | 1071 | WP_038241732.1 | LPS export ABC transporter permease LptG | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 3173375..3182515 | 9140 | |
| - | inside | IScluster/Tn | - | - | 3177887..3183841 | 5954 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 97 a.a. Molecular weight: 11494.42 Da Isoelectric Point: 9.9816
>T218973 WP_038275268.1 NZ_CP084642:c3182271-3181981 [Yersinia ruckeri]
MTFNIDFDERALKEWHKLDKTIREQFKKKLRKLQENPYIESARLHGDLAGCFKIKLRASGFRLIYQVIDEEIVIWIVAVG
KREDEKAYDIAKKRIQ
MTFNIDFDERALKEWHKLDKTIREQFKKKLRKLQENPYIESARLHGDLAGCFKIKLRASGFRLIYQVIDEEIVIWIVAVG
KREDEKAYDIAKKRIQ
Download Length: 291 bp
>T218973 NZ_CP116145:3464670-3464957 [Escherichia coli]
ATGCCAATGGAGTTTGAATGGGATGCAAACAAGGCCAAAAGTAATCGGGTGAAACATGGCATCCGCTTTGAAGATGCGGT
GTTAGTGTTTGATGATCCACAACATTTGTCACAGCAAGATCGCATAGAAAACGGTGAGTATCGCTGGCAGACTATCGGCC
TGGTTCACGGTATCGTGGTTATTCTGGTTGCGCATACCATCCGTTTCGAAAGCGGAAATGAAATTATTCGAATCATCAGT
GCACGAAAAGCAGATCGTAAAGAGAGGAGCCGCTATGAGCATGGTTAA
ATGCCAATGGAGTTTGAATGGGATGCAAACAAGGCCAAAAGTAATCGGGTGAAACATGGCATCCGCTTTGAAGATGCGGT
GTTAGTGTTTGATGATCCACAACATTTGTCACAGCAAGATCGCATAGAAAACGGTGAGTATCGCTGGCAGACTATCGGCC
TGGTTCACGGTATCGTGGTTATTCTGGTTGCGCATACCATCCGTTTCGAAAGCGGAAATGAAATTATTCGAATCATCAGT
GCACGAAAAGCAGATCGTAAAGAGAGGAGCCGCTATGAGCATGGTTAA
Antitoxin
Download Length: 85 a.a. Molecular weight: 9680.07 Da Isoelectric Point: 4.8283
>AT218973 WP_005175264.1 NZ_CP084642:c3182515-3182261 [Yersinia ruckeri]
MSTIQIRVDDELKKSAYQAFEKLNLSPSDALRLFLRYVAENEKLPFSEVSVMVSNQDEDADILAVVRERLKNPAKRIRVN
IDDL
MSTIQIRVDDELKKSAYQAFEKLNLSPSDALRLFLRYVAENEKLPFSEVSVMVSNQDEDADILAVVRERLKNPAKRIRVN
IDDL
Download Length: 255 bp
>AT218973 NZ_CP116145:3464944-3465246 [Escherichia coli]
ATGAGCATGGTTAAACATAAACGAGGGACACCCTCTACACTCGATGTGCAGCATGAGGCCGAACTGAAGGCACTGGCGAA
TAAATTCGACGAAGATATTGATTACAGTGATATCCCGCCTTCCAGCGATGAGCAATGGTCTAACGCAGAACGCGGTAAGT
TTTATCGGCCATTGAAAACCCAGGCTTCGGTGCGTATTGATGCTGATGTGATGGAATGGCTGAAGCGACCTGGTAAAGGC
TATCAAACTCGCCTGAACGCAATTTTACGTGAAGCGATGCTGCGCGATCAGAACAAAAAATAA
ATGAGCATGGTTAAACATAAACGAGGGACACCCTCTACACTCGATGTGCAGCATGAGGCCGAACTGAAGGCACTGGCGAA
TAAATTCGACGAAGATATTGATTACAGTGATATCCCGCCTTCCAGCGATGAGCAATGGTCTAACGCAGAACGCGGTAAGT
TTTATCGGCCATTGAAAACCCAGGCTTCGGTGCGTATTGATGCTGATGTGATGGAATGGCTGAAGCGACCTGGTAAAGGC
TATCAAACTCGCCTGAACGCAATTTTACGTGAAGCGATGCTGCGCGATCAGAACAAAAAATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0T9LYG3 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A1JJ37 |