Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | sanaTA/AbiEii-DUF6088 |
| Location | 3175824..3177162 | Replicon | chromosome |
| Accession | NZ_CP084642 | ||
| Organism | Yersinia ruckeri strain 17Y0161 | ||
Toxin (Protein)
| Gene name | sanaT | Uniprot ID | - |
| Locus tag | LGL90_RS14470 | Protein ID | WP_234049238.1 |
| Coordinates | 3175824..3176774 (-) | Length | 317 a.a. |
Antitoxin (Protein)
| Gene name | sanaA | Uniprot ID | A0A848MNT5 |
| Locus tag | LGL90_RS14475 | Protein ID | WP_038245317.1 |
| Coordinates | 3176767..3177162 (-) | Length | 132 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LGL90_RS14450 (LGL90_14480) | 3172635..3173327 | - | 693 | WP_038245321.1 | oligogalacturonate-specific porin KdgM family protein | - |
| LGL90_RS14455 (LGL90_14485) | 3173375..3174529 | - | 1155 | WP_038245380.1 | N-acetylneuraminate epimerase | - |
| LGL90_RS14460 (LGL90_14490) | 3175132..3175305 | - | 174 | Protein_2802 | type IV toxin-antitoxin system YeeU family antitoxin | - |
| LGL90_RS14465 (LGL90_14495) | 3175331..3175456 | - | 126 | Protein_2803 | antirestriction protein | - |
| LGL90_RS14470 (LGL90_14500) | 3175824..3176774 | - | 951 | WP_234049238.1 | nucleotidyl transferase AbiEii/AbiGii toxin family protein | Toxin |
| LGL90_RS14475 (LGL90_14505) | 3176767..3177162 | - | 396 | WP_038245317.1 | DUF6088 family protein | Antitoxin |
| LGL90_RS14480 (LGL90_14510) | 3177237..3177467 | - | 231 | Protein_2806 | DUF4942 domain-containing protein | - |
| LGL90_RS14485 (LGL90_14515) | 3177617..3177745 | + | 129 | Protein_2807 | helix-turn-helix domain-containing protein | - |
| LGL90_RS14490 (LGL90_14520) | 3177738..3177858 | + | 121 | Protein_2808 | transposase | - |
| LGL90_RS14495 (LGL90_14525) | 3177887..3178183 | - | 297 | Protein_2809 | integrase core domain-containing protein | - |
| LGL90_RS14500 (LGL90_14530) | 3178182..3178580 | + | 399 | Protein_2810 | integrase core domain-containing protein | - |
| LGL90_RS14505 (LGL90_14535) | 3178599..3178885 | - | 287 | Protein_2811 | hypothetical protein | - |
| LGL90_RS14510 (LGL90_14540) | 3178906..3179973 | - | 1068 | WP_038245756.1 | macro domain-containing protein | - |
| LGL90_RS14515 (LGL90_14545) | 3179970..3180626 | - | 657 | WP_096823271.1 | DUF4433 domain-containing protein | - |
| LGL90_RS14520 (LGL90_14550) | 3180629..3181204 | - | 576 | WP_234049239.1 | DarT ssDNA thymidine ADP-ribosyltransferase family protein | - |
| LGL90_RS14525 (LGL90_14555) | 3181328..3181717 | - | 390 | WP_234049240.1 | restriction endonuclease subunit S | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 3173375..3182515 | 9140 | |
| - | inside | IScluster/Tn | - | - | 3177887..3183841 | 5954 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 317 a.a. Molecular weight: 36070.39 Da Isoelectric Point: 4.5996
>T218971 WP_234049238.1 NZ_CP084642:c3176774-3175824 [Yersinia ruckeri]
MDDLTKLFPDVADALGIESVSIVEKDYYIVELLRLLQPLDFDTHQLVFAGGTALSKAGISLNRMSEDVDIKLVPVAGFTQ
QYSRGQRKDIRKGIIRTVIETITASGTFRMDEGYPKVTRDEYRYNEIPVRYPQEYVQVPCLRPFIKLELMETDLLEAAEN
RAISSLVMDLTKKGEVVRAFPCATIGSTQAEKLISMMRRTAASMRDVERAVDESLVRHIYDNFCIVREKGADVPVLKQFV
QECIEQDIERYGAQYPEFCESPVEELKMGLEELVSNPVYKERYLQFVTPMVFGESHVSWEEAYACFRKTVLDVVDA
MDDLTKLFPDVADALGIESVSIVEKDYYIVELLRLLQPLDFDTHQLVFAGGTALSKAGISLNRMSEDVDIKLVPVAGFTQ
QYSRGQRKDIRKGIIRTVIETITASGTFRMDEGYPKVTRDEYRYNEIPVRYPQEYVQVPCLRPFIKLELMETDLLEAAEN
RAISSLVMDLTKKGEVVRAFPCATIGSTQAEKLISMMRRTAASMRDVERAVDESLVRHIYDNFCIVREKGADVPVLKQFV
QECIEQDIERYGAQYPEFCESPVEELKMGLEELVSNPVYKERYLQFVTPMVFGESHVSWEEAYACFRKTVLDVVDA
Download Length: 951 bp
>T218971 NZ_CP116145:3282421-3282771 [Escherichia coli]
ATGGTAAAGAAAAGTGAATTTGAACGGGGAGACATTGTGCTGGTTGGCTTTGATCCAGCAAGCGGCCATGAACAGCAAGG
TGCTGGTCGACCTGCGCTTGTGCTCTCCGTTCAAGCCTTTAATCAACTGGGAATGACGCTGGTGGCCCCCATTACGCAGG
GCGGAAATTTTGCCCGTTATGCCGGATTTAGCGTTCCTTTACATTGCGAAGAAGGCGATGTGCACGGCGTGGTGCTGGTG
AATCAGGTGCGGATGATGGATCTACGCGCCCGGCTGGCAAAGCGTATTGGTCTGGCTGCGGATGAGGTGGTGGAAGAGGC
GTTATTACGCTTGCAGGCGGTGGTGGAATAA
ATGGTAAAGAAAAGTGAATTTGAACGGGGAGACATTGTGCTGGTTGGCTTTGATCCAGCAAGCGGCCATGAACAGCAAGG
TGCTGGTCGACCTGCGCTTGTGCTCTCCGTTCAAGCCTTTAATCAACTGGGAATGACGCTGGTGGCCCCCATTACGCAGG
GCGGAAATTTTGCCCGTTATGCCGGATTTAGCGTTCCTTTACATTGCGAAGAAGGCGATGTGCACGGCGTGGTGCTGGTG
AATCAGGTGCGGATGATGGATCTACGCGCCCGGCTGGCAAAGCGTATTGGTCTGGCTGCGGATGAGGTGGTGGAAGAGGC
GTTATTACGCTTGCAGGCGGTGGTGGAATAA
Antitoxin
Download Length: 132 a.a. Molecular weight: 14406.76 Da Isoelectric Point: 11.0360
>AT218971 WP_038245317.1 NZ_CP084642:c3177162-3176767 [Yersinia ruckeri]
MTTKARIQLRLKRSKRYVFTRDDFKDLAGYDQIGRALRELVKEGQLLKVGYGVYTKARQNVITGKLMPAAPGGSAAVVIE
ALERLKVDYRLVGATSAYNSGKSTQIPASLEIKTSPRFKRTLSVGSSKLNG
MTTKARIQLRLKRSKRYVFTRDDFKDLAGYDQIGRALRELVKEGQLLKVGYGVYTKARQNVITGKLMPAAPGGSAAVVIE
ALERLKVDYRLVGATSAYNSGKSTQIPASLEIKTSPRFKRTLSVGSSKLNG
Download Length: 396 bp
>AT218971 NZ_CP116145:3282176-3282427 [Escherichia coli]
ATGCGTATTACCATAAAAAGATGGGGGAACAGTGCAGGTATGGTCATTCCCAATATCGTAATGAAAGAACTTAACTTACA
GCCGGGGCAGAGCGTGGAGGCGCAAGTGAGCAACAATCAACTGATTCTGACACCCATCTCCAGGCGCTACTCGCTTGATG
AACTGCTGGCACAGTGTGACATGAACGCCGCGGAACTTAGCGAGCAGGATGTCTGGGGTAAATCCACCCCTGCGGGTGAC
GAAATATGGTAA
ATGCGTATTACCATAAAAAGATGGGGGAACAGTGCAGGTATGGTCATTCCCAATATCGTAATGAAAGAACTTAACTTACA
GCCGGGGCAGAGCGTGGAGGCGCAAGTGAGCAACAATCAACTGATTCTGACACCCATCTCCAGGCGCTACTCGCTTGATG
AACTGCTGGCACAGTGTGACATGAACGCCGCGGAACTTAGCGAGCAGGATGTCTGGGGTAAATCCACCCCTGCGGGTGAC
GAAATATGGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|