218970

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 2668673..2669296 Replicon chromosome
Accession NZ_CP084642
Organism Yersinia ruckeri strain 17Y0161

Toxin (Protein)


Gene name Hha Uniprot ID A0A085U5C4
Locus tag LGL90_RS12250 Protein ID WP_038243726.1
Coordinates 2669093..2669296 (+) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A085U5C5
Locus tag LGL90_RS12245 Protein ID WP_004718732.1
Coordinates 2668673..2669041 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LGL90_RS12230 (LGL90_12260) 2666926..2667180 + 255 WP_038243728.1 type B 50S ribosomal protein L31 -
LGL90_RS12235 (LGL90_12265) 2667200..2667343 + 144 WP_004718738.1 type B 50S ribosomal protein L36 -
LGL90_RS12240 (LGL90_12270) 2667462..2667599 - 138 WP_186368427.1 hypothetical protein -
LGL90_RS12245 (LGL90_12275) 2668673..2669041 + 369 WP_004718732.1 Hha toxicity modulator TomB Antitoxin
LGL90_RS12250 (LGL90_12280) 2669093..2669296 + 204 WP_038243726.1 expression modulating protein YmoA Toxin
LGL90_RS12255 (LGL90_12285) 2669615..2670306 + 692 Protein_2378 IS6 family transposase -
LGL90_RS12260 (LGL90_12290) 2670387..2671526 - 1140 WP_145497661.1 glycosyltransferase family 4 protein -
LGL90_RS12265 (LGL90_12295) 2671561..2672595 - 1035 WP_145497663.1 hypothetical protein -
LGL90_RS12270 (LGL90_12300) 2672867..2674132 - 1266 WP_145497665.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8037.27 Da        Isoelectric Point: 6.4573

>T218970 WP_038243726.1 NZ_CP084642:2669093-2669296 [Yersinia ruckeri]
MTKTDYLMRLRKCTTIDTLERVIEKNKYELSDDELELFYSAADHRLAELTMNKLYDKIPATVWQHVK

Download         Length: 204 bp

>T218970 NZ_CP116145:3179497-3179670 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTTCTGGTCGGAATAACCTGGCCAATGAGTTTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14277.08 Da        Isoelectric Point: 4.4225

>AT218970 WP_004718732.1 NZ_CP084642:2668673-2669041 [Yersinia ruckeri]
MDEYSPKRHDIAQLKFLCENLYDEGIATLGDSHHGWVNDPTSAVNLQLNDLIEHIASFVMSFKIKYADEIDLCELVEEYL
DDTYTLFSSYGINDPDLRRWQKTKDRLFRLFSGEYLCALMKN

Download         Length: 369 bp

>AT218970 NZ_CP116145:3179173-3179469 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGGTT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAACT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTCAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAGCATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A085U5C4

Antitoxin

Source ID Structure
AlphaFold DB A0A085U5C5

References