Detailed information of TA system TA218969

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /RES-TIGR02293
• Location: 1710453..1711371
• Replicon: chromosome
• Accession: NZ_CP084642
• Organism: Yersinia ruckeri strain 17Y0161

Toxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: LGL90_RS08005
• Protein ID: WP_145497061.1
• Coordinates: 1710453..1710911 (-)
• Length: 153 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: A0A085U7R3
• Locus tag: LGL90_RS08010
• Protein ID: WP_038242631.1
• Coordinates: 1710925..1711371 (-)
• Length: 149 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LGL90_RS07975 (LGL90_08000)	1706375..1707040	+	666	WP_145497062.1	phage shock protein PspA	-
LGL90_RS07980 (LGL90_08005)	1707124..1707351	+	228	WP_038242637.1	envelope stress response membrane protein PspB	-
LGL90_RS07985 (LGL90_08010)	1707351..1707710	+	360	WP_004717559.1	envelope stress response membrane protein PspC	-
LGL90_RS07990 (LGL90_08015)	1707873..1708016	+	144	WP_234049335.1	phage shock protein PspD	-
LGL90_RS07995 (LGL90_08020)	1707997..1709394	+	1398	WP_004717556.1	YcjX family protein	-
LGL90_RS08000 (LGL90_08025)	1709391..1710449	+	1059	WP_038242635.1	YcjF family protein	-
LGL90_RS08005 (LGL90_08030)	1710453..1710911	-	459	WP_145497061.1	RES domain-containing protein	Toxin
LGL90_RS08010 (LGL90_08035)	1710925..1711371	-	447	WP_038242631.1	DUF2384 domain-containing protein	Antitoxin
LGL90_RS08015 (LGL90_08040)	1711689..1713296	+	1608	WP_038251390.1	transcriptional regulator TyrR	-
LGL90_RS08020 (LGL90_08045)	1713331..1713834	-	504	WP_004717547.1	thiol peroxidase	-
LGL90_RS08025 (LGL90_08050)	1713984..1714958	+	975	WP_145497060.1	L-Ala-D/L-Glu epimerase	-
LGL90_RS08030 (LGL90_08055)	1714969..1715673	-	705	WP_234049336.1	murein tripeptide amidase MpaA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (3-147)

Antitoxin

• Antitoxin Xre/MbcA/ParS-like, toxin-binding domain (94-145)

Sequences

Toxin

Protein

• Length: 153 a.a.
• Molecular weight: 17044.50 Da
• Isoelectric Point: 6.6384

>T218969 WP_145497061.1 NZ_CP084642:c1710911-1710453 [Yersinia ruckeri]
VMLYRIVHNRYLATAWTGYGAETYGGRWNHKGHAAIYLASSVSLAMLETLVHVEDSATLNDFNLFQITIPDNAIMVLQQQ
DWPRGWRDDPTPVATMDIGTEWIGSASSVGLLVPSTLVPLERNMLVNPKHRDFASCLKSINPLTFSFDPRLK

Nucleotide

• Length: 459 bp

>T218969 NZ_CP116145:2859768-2860079 [Escherichia coli]
ATGCTCTTCATCGAAACGGAAATTTTTACTGAAGATGTTCAAAAACTGCTGAACGACGATGAATTCAGTCGTTTTCAGTT
TTTCCTGGCCTTGAATCCTGACTATGGTGAGGTAATACCTGAAACTGGTGGGTTAAGAAAGGTTCGATGGGTCTCAGGAG
GAAAGGGGAAACGTGCTGGTGTCAGGGTTATTTACTTTCATCAGGTTAAACATTATGAGATCAGATTACTGCTTATTTAT
CGTAAGGGTATTAAAGATGATCTGTCTCCCCAGGAAAAAGCAATGCTCCGGTTGTTAAATACGAGGTGGTAA

Antitoxin

Protein

• Length: 149 a.a.
• Molecular weight: 16406.87 Da
• Isoelectric Point: 8.0956

>AT218969 WP_038242631.1 NZ_CP084642:c1711371-1710925 [Yersinia ruckeri]
MRTYHPSPMAKVSALWREIGLPASRGTALVDSIKLGFTVDVIDTIHLWADMPKSEILRATGIPSRSLTRRRTHDGRFTPE
ESERIARFVRVMDAAVDLFGGDRTKATAWMSMPVKGLGNRTPDSLLETETGALEICDLIGRLEHGVFS

Nucleotide

• Length: 447 bp

>AT218969 NZ_CP116145:2860080-2860370 [Escherichia coli]
ATGGATAAGGCACTTTTTGAGCGGTTGACTCACAGCATGGCCCAGATGAATGAAATTATTGAAGGAACGCGACAGCCTTC
ACGGACTTTTGAAGTTGATGCTATGAAAATCAAAGAAATACGCCGCGCTTCAGGGTTGTCACAATCTAAATTTGCCGATC
TTATTTCCGTAAGCGTAGACACGTTGCGTAACTGGGAGCAGGGGCGACGTTCACCGACCGGGCCTGCAAAGGCTTTGCTG
CGAGCGATTGCCAATGATCCGCAACATGTGCTGCAAGCACTTAACCGTTAG

Structures

Antitoxin

• AlphaFold DB: A0A085U7R3