Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pmenTA/darT(toxin)
Location 3273407..3275127 Replicon chromosome
Accession NZ_CP084641
Organism Yersinia ruckeri strain 17Y0163

Toxin (Protein)


Gene name pmenT Uniprot ID -
Locus tag LGL88_RS15050 Protein ID WP_096823271.1
Coordinates 3274471..3275127 (-) Length 219 a.a.

Antitoxin (Protein)


Gene name pmenA Uniprot ID -
Locus tag LGL88_RS15045 Protein ID WP_096823272.1
Coordinates 3273407..3274474 (-) Length 356 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LGL88_RS14995 (LGL88_15030) 3269635..3269808 - 174 Protein_2909 type IV toxin-antitoxin system YeeU family antitoxin -
LGL88_RS15000 (LGL88_15035) 3269834..3269959 - 126 Protein_2910 antirestriction protein -
LGL88_RS15005 (LGL88_15040) 3270339..3271289 - 951 WP_234055605.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein -
LGL88_RS15010 (LGL88_15045) 3271282..3271677 - 396 WP_038245317.1 DUF6088 family protein -
LGL88_RS15015 (LGL88_15050) 3271752..3271982 - 231 Protein_2913 DUF4942 domain-containing protein -
LGL88_RS15020 (LGL88_15055) 3272132..3272260 + 129 Protein_2914 helix-turn-helix domain-containing protein -
LGL88_RS15025 (LGL88_15060) 3272274..3272379 + 106 Protein_2915 transposase -
LGL88_RS15030 (LGL88_15065) 3272408..3272704 - 297 Protein_2916 integrase core domain-containing protein -
LGL88_RS15035 (LGL88_15070) 3272703..3273101 + 399 Protein_2917 integrase core domain-containing protein -
LGL88_RS15040 (LGL88_15075) 3273120..3273386 - 267 Protein_2918 hypothetical protein -
LGL88_RS15045 (LGL88_15080) 3273407..3274474 - 1068 WP_096823272.1 macro domain-containing protein Antitoxin
LGL88_RS15050 (LGL88_15085) 3274471..3275127 - 657 WP_096823271.1 DUF4433 domain-containing protein Toxin
LGL88_RS15055 (LGL88_15090) 3275130..3275705 - 576 WP_234055606.1 DarT ssDNA thymidine ADP-ribosyltransferase family protein -
LGL88_RS15060 (LGL88_15095) 3275829..3276218 - 390 WP_234055607.1 restriction endonuclease subunit S -
LGL88_RS15065 (LGL88_15100) 3276482..3276772 - 291 WP_038275268.1 type II toxin-antitoxin system RelE/ParE family toxin -
LGL88_RS15070 (LGL88_15105) 3276762..3277016 - 255 WP_005175264.1 type II toxin-antitoxin system RelB/DinJ family antitoxin -
LGL88_RS15080 (LGL88_15115) 3278692..3279114 - 423 WP_230675767.1 very short patch repair endonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 3273407..3287015 13608
- inside IScluster/Tn - - 3272408..3278346 5938


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

ssDNA thymidine ADP-ribosyltransferase, DarT

(17-217)

Antitoxin

Macro domain

(18-129)


Sequences

Toxin        


Download         Length: 219 a.a.        Molecular weight: 25214.72 Da        Isoelectric Point: 6.6007

>T218958 WP_096823271.1 NZ_CP084641:c3275127-3274471 [Yersinia ruckeri]
VAYDYSTSLNPEKALIWRIVHRDNIPWILDNGLHCGNSPVQAEDWINIGNPELIDKRAGHLVPTGMRGTLHDYVPFYFTP
FSPMLMNIRSGRGGIKQRPNEEIVILVSSLRNMVAQNVSFVFTDSHAYYNLANYFTELDSLNQIDWPILQARDFRRDQDD
LAKFERYQAEALIWKHCPIALLGGMICYNDGVRLQLEQWLSQRNLSMPVHARAGWYFS

Download         Length: 657 bp

>T218958 NZ_CP116145:c527248-527146 [Escherichia coli]
GCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 356 a.a.        Molecular weight: 40847.21 Da        Isoelectric Point: 6.3136

>AT218958 WP_096823272.1 NZ_CP084641:c3274474-3273407 [Yersinia ruckeri]
MITFTQGNLLDAPVEALVNTVNTVGVMGKGIALMFKERFPVNMKAYALACKHKQVMTGKMFITETGELMGPRWIVNFPTK
QHWRADSRMEWVEDGLQDLRRFLIEEKVQSIAIPPLGAGNGGLNWSDVRMRIESALGDLQDTEILIYEPTEKYQNVAKST
GVKKLTPARALIAELVRRYWVLGMECSLLEIQKLAWLLQRAIEQHQQEDVLKLRFEAHYYGPYAPNLNHLLNALDGTYLK
AEKRIPDTQPLDVIWFNDQEKEHINLWLNNEAKEWLPALEQVSQLIDGFESPFGLELLATVDWLLTRGKCQPTLDSVKEG
LHQWPAGERWASRKMKLFDDKNLQFAINRVMEFHC

Download         Length: 1068 bp

>AT218958 NZ_CP116145:527108-527376 [Escherichia coli]
AAAGTCAGCGAAGGGAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCTCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGTGGTGGTCATCAGCTTAAATATTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References