Detailed information of TA system TA218957

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): sanaTA/AbiEii-DUF6088
• Location: 3270339..3271677
• Replicon: chromosome
• Accession: NZ_CP084641
• Organism: Yersinia ruckeri strain 17Y0163

Toxin (Protein)

• Gene name: sanaT
• Uniprot ID: -
• Locus tag: LGL88_RS15005
• Protein ID: WP_234055605.1
• Coordinates: 3270339..3271289 (-)
• Length: 317 a.a.

Antitoxin (Protein)

• Gene name: sanaA
• Uniprot ID: A0A848MNT5
• Locus tag: LGL88_RS15010
• Protein ID: WP_038245317.1
• Coordinates: 3271282..3271677 (-)
• Length: 132 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LGL88_RS14985 (LGL88_15020)	3267138..3267830	-	693	WP_038245321.1	oligogalacturonate-specific porin KdgM family protein	-
LGL88_RS14990 (LGL88_15025)	3267878..3269032	-	1155	WP_038245380.1	N-acetylneuraminate epimerase	-
LGL88_RS14995 (LGL88_15030)	3269635..3269808	-	174	Protein_2909	type IV toxin-antitoxin system YeeU family antitoxin	-
LGL88_RS15000 (LGL88_15035)	3269834..3269959	-	126	Protein_2910	antirestriction protein	-
LGL88_RS15005 (LGL88_15040)	3270339..3271289	-	951	WP_234055605.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
LGL88_RS15010 (LGL88_15045)	3271282..3271677	-	396	WP_038245317.1	DUF6088 family protein	Antitoxin
LGL88_RS15015 (LGL88_15050)	3271752..3271982	-	231	Protein_2913	DUF4942 domain-containing protein	-
LGL88_RS15020 (LGL88_15055)	3272132..3272260	+	129	Protein_2914	helix-turn-helix domain-containing protein	-
LGL88_RS15025 (LGL88_15060)	3272274..3272379	+	106	Protein_2915	transposase	-
LGL88_RS15030 (LGL88_15065)	3272408..3272704	-	297	Protein_2916	integrase core domain-containing protein	-
LGL88_RS15035 (LGL88_15070)	3272703..3273101	+	399	Protein_2917	integrase core domain-containing protein	-
LGL88_RS15040 (LGL88_15075)	3273120..3273386	-	267	Protein_2918	hypothetical protein	-
LGL88_RS15045 (LGL88_15080)	3273407..3274474	-	1068	WP_096823272.1	macro domain-containing protein	-
LGL88_RS15050 (LGL88_15085)	3274471..3275127	-	657	WP_096823271.1	DUF4433 domain-containing protein	-
LGL88_RS15055 (LGL88_15090)	3275130..3275705	-	576	WP_234055606.1	DarT ssDNA thymidine ADP-ribosyltransferase family protein	-
LGL88_RS15060 (LGL88_15095)	3275829..3276218	-	390	WP_234055607.1	restriction endonuclease subunit S	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (39-304)

Antitoxin

• Protein of unknown function DUF6088 (10-114)

Sequences

Toxin

Protein

• Length: 317 a.a.
• Molecular weight: 36013.34 Da
• Isoelectric Point: 4.5092

>T218957 WP_234055605.1 NZ_CP084641:c3271289-3270339 [Yersinia ruckeri]
MDDLTKLFPDVADALGIESVSIVEKDYYIVELLRLLQPMDFDTHQLVFAGGTALSKAGISLNRMSEDVDIKLVPLAGFSQ
QYSRGQRKSIRKGIIQTIIETVAASGTFLLDEEYPKVTRDEYRYNEIPVRYPQEYVQVPCLRPFIKLELMETDLLEAAEN
RAISSLVMDLTKKGEVVRAFPCATIGSTQAEKLISMMRRTAASMRDVERAVDESLVRHIYDNFCIVREKGADVPVLKQFV
QECIEQDIERYGAQYPEFCESPVEELKMGLEELVSNPVYKERYLQFVTPMVFGESHVSWEEAYACFRKTVLDVVDA

Nucleotide

• Length: 951 bp

>T218957 NZ_CP116145:c234991-233669 [Escherichia coli]
ATGCCTAAACTAGTCACTTGGATGAACAACCAGCGGGTAGGCGAGTTAACGAAGTTAGCCAACGGCGCGCACACCTTTAA
GTATGCAGCTGAGTGGTTAGCCAGCCGTTATGCCAGACCGTTGTCACTTTCGCTGCCATTGCAGAGGGGGAATATCACCT
CTGATGCCGTATTTAACTTCTTCGATAACCTGTTACCCGATAGCCCGATTGTACGTGACCGGATCGTTAAACGTTATCAT
GCTAAATCCAGACAACCGTTTGATTTATTGTCAGAAATAGGGCGAGACAGCGTTGGTGCCGTGACGTTAATCCCCGAAGA
TGAAACCGTAACGTGTCCGATAATGGCATGGGAAAAGCTTACTGAAGCCAGACTTGAAGAAGTATTAACGGCTTATAAAG
CAGATATCCCGTTAGGCATGATTAGAGAAGAAAATGACTTTCGCATCTCGGTTGCTGGCGCACAGGAGAAGACTGCGCTG
CTCAGAATAGGCAATGACTGGTGCATTCCGAAGGGAATAACGCCAACGACGCACATTATCAAATTGCCGATTGGCGAAAT
CAGACAGCCCAATGCGACGCTCGATCTTAGCCAAAGCGTTGATAATGAGTATTACTGTTTGCTGCTGGCGAAAGAACTCG
GGTTGAATGTTCCGGACGCAGAAATCATTAAAGCGGGAAGGGTGCGCGCGTTAGCGGTCGAACGTTTTGACAGGCGTTGG
AATACTGAGCGAACGGTTTTACTTCGCTTGCCACAGGAGGATATGTGCCAGACATTCGGTTTACCTTCATCGGTGAAATA
TGAATCAGATGGAGGCCCCGGTATCGCGCAAATTATGGCTTTTTTGATGGGGTCCAGCGAGGCGCTGAAAGATCGCTATG
ATTTTATGAAGTTTCAGGTCTTCCAGTGGTTGATTGGCGCAACGGATGGCCATGCAAAAAACTTCTCCGTATTTATTCAG
GCTGGCGGCAGTTATCGGCTCACACCATTTTACGACATCATTTCGGCATTTCCGGTCCTTGGCGGTACGGGAATACACAT
CAGCGATCTCAAACTGGCAATGGGGCTTAACGCATCCAAAGGCAAAAAAACGGCAATCGATAAAATTTATCCGCGACATT
TTCTGGCGACAGCAAAGGTGCTGAAATTCCCGGAAGTGCAGATGCATGAAATCCTGAGTGACTTTGCCAGAATGATTCCG
GCAGCACTGGATAACGTGAAGACTTCATTACCGACAGATTTTCCGGAGAACGTGGTGACGGCAGTTGAAACCAATGTGTT
GAGGTTGCACGATCGGTTAAGCCGAGAATACGGTATTAAGTAA

Antitoxin

Protein

• Length: 132 a.a.
• Molecular weight: 14406.76 Da
• Isoelectric Point: 11.0360

>AT218957 WP_038245317.1 NZ_CP084641:c3271677-3271282 [Yersinia ruckeri]
MTTKARIQLRLKRSKRYVFTRDDFKDLAGYDQIGRALRELVKEGQLLKVGYGVYTKARQNVITGKLMPAAPGGSAAVVIE
ALERLKVDYRLVGATSAYNSGKSTQIPASLEIKTSPRFKRTLSVGSSKLNG

Nucleotide

• Length: 396 bp

>AT218957 NZ_CP116145:c235257-234991 [Escherichia coli]
ATGATGAGCTTTCAGAAGATCTATAGCCCAACGCAATTGGCGAATGCAATGAAACTGGTTCGCCAGCAAAACGGCTGGAC
GCAGAGCGAGTTGGCGAAAAAAATCGGCATTAAGCAGGCGACAATTTCCAATTTCGAAAACAATCCTGACAATACCTCGC
TCACGACATTTTTTAAGATTTTACAGTCGCTTGAACTCTCAATGACGCTATGCGACGCGAAAAATGCCTCGCCAGAAGCA
ACAGAACAGCAAGATCTGGAGTGGTAA

Structures

Antitoxin

• AlphaFold DB: A0A848MNT5