Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 2782959..2783582 Replicon chromosome
Accession NZ_CP084641
Organism Yersinia ruckeri strain 17Y0163

Toxin (Protein)


Gene name Hha Uniprot ID A0A085U5C4
Locus tag LGL88_RS12890 Protein ID WP_038243726.1
Coordinates 2783379..2783582 (+) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A085U5C5
Locus tag LGL88_RS12885 Protein ID WP_004718732.1
Coordinates 2782959..2783327 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LGL88_RS12870 (LGL88_12905) 2781212..2781466 + 255 WP_038243728.1 type B 50S ribosomal protein L31 -
LGL88_RS12875 (LGL88_12910) 2781486..2781629 + 144 WP_004718738.1 type B 50S ribosomal protein L36 -
LGL88_RS12880 (LGL88_12915) 2781748..2781885 - 138 WP_186368427.1 hypothetical protein -
LGL88_RS12885 (LGL88_12920) 2782959..2783327 + 369 WP_004718732.1 Hha toxicity modulator TomB Antitoxin
LGL88_RS12890 (LGL88_12925) 2783379..2783582 + 204 WP_038243726.1 expression modulating protein YmoA Toxin
LGL88_RS12900 (LGL88_12935) 2784391..2784705 + 315 WP_004718728.1 MGMT family protein -
LGL88_RS12905 (LGL88_12940) 2785083..2785946 + 864 WP_004718726.1 acyl-CoA thioesterase II -
LGL88_RS12910 (LGL88_12945) 2786061..2787350 - 1290 WP_234055581.1 ammonium transporter AmtB -
LGL88_RS12915 (LGL88_12950) 2787389..2787727 - 339 WP_007886947.1 P-II family nitrogen regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8037.27 Da        Isoelectric Point: 6.4573

>T218956 WP_038243726.1 NZ_CP084641:2783379-2783582 [Yersinia ruckeri]
MTKTDYLMRLRKCTTIDTLERVIEKNKYELSDDELELFYSAADHRLAELTMNKLYDKIPATVWQHVK

Download         Length: 204 bp

>T218956 NZ_CP116137:c150635-150105 [Escherichia coli]
ATGGACGGTTTAAGGATTGAGATTTTTTCAGAGGAAGTTGAATATCAATTAAGCAACTTCGATTGTGGAGAAGAGTATCT
GAATACTTTTCTCACCGATCATCTGCAACGTCAGCACAGTAGTAAGATTTTACGGGGTTATCTGCTCGTGACGAGAGAGG
ATAGACCACGTGTCATGGGGTACTACACCCTGTCAGGCAGTTGCTTTGAGAAAATACTTCTCCCCAGCAAAACACAACAA
AAGCGTGTGCCCTACAAAAATGTGCCGAGCGTGACTTTGGGCCGTCTGGCAATTGATAAAAGCATTCATCACCAGGGATA
TGGAGAAACACTTGTTACCCATGCGATGAAAGTCGTGTATCAGGCCTCGCAGGCTGTGGGTATACACGGAATGTTCGTGG
AGGCGCTGAACGATAACGCCAAAAAATTCTACCTTCGACTGGGTTTTATACAGTTAAAGGAAGAAAACTGTAATTCGCTC
TTCTACCCGACAAAATCTATTGAAGTATTGTTCGAAGTAAATGACGAATAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14277.08 Da        Isoelectric Point: 4.4225

>AT218956 WP_004718732.1 NZ_CP084641:2782959-2783327 [Yersinia ruckeri]
MDEYSPKRHDIAQLKFLCENLYDEGIATLGDSHHGWVNDPTSAVNLQLNDLIEHIASFVMSFKIKYADEIDLCELVEEYL
DDTYTLFSSYGINDPDLRRWQKTKDRLFRLFSGEYLCALMKN

Download         Length: 369 bp

>AT218956 NZ_CP116137:c150908-150639 [Escherichia coli]
ATGTCAGCACTGAAGAAGCAGCGCATCGATCTGAGATTAAATGAAGACGACAAACACATGATCGAAGAAGCTGCAGCAAT
GACTAACCAGTCCATTTCGCAGTTCATGGTCAGTACCGCCTCAGCACGTGCTGCTGAAGTTATTGATCAGCACCGTCGCC
TGCTCCTCAATGAGGAGTCCTGGAAACTGGTTATGGATGCAATCACTAATCCGCCAGCACCAAATGACCGGCTGAAACGC
GCCACTAACCGTCTCCGGGAACTGGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A085U5C4

Antitoxin

Source ID Structure
AlphaFold DB A0A085U5C5

References