Detailed information of TA system TA218955

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /RES-TIGR02293
• Location: 1785754..1786672
• Replicon: chromosome
• Accession: NZ_CP084641
• Organism: Yersinia ruckeri strain 17Y0163

Toxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: LGL88_RS08365
• Protein ID: WP_145497061.1
• Coordinates: 1785754..1786212 (-)
• Length: 153 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: A0A085U7R3
• Locus tag: LGL88_RS08370
• Protein ID: WP_038242631.1
• Coordinates: 1786226..1786672 (-)
• Length: 149 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LGL88_RS08335 (LGL88_08360)	1781677..1782342	+	666	WP_145497062.1	phage shock protein PspA	-
LGL88_RS08340 (LGL88_08365)	1782426..1782653	+	228	WP_038242637.1	envelope stress response membrane protein PspB	-
LGL88_RS08345 (LGL88_08370)	1782653..1783012	+	360	WP_004717559.1	envelope stress response membrane protein PspC	-
LGL88_RS08350 (LGL88_08375)	1783174..1783317	+	144	WP_234049335.1	phage shock protein PspD	-
LGL88_RS08355 (LGL88_08380)	1783298..1784695	+	1398	WP_004717556.1	YcjX family protein	-
LGL88_RS08360 (LGL88_08385)	1784692..1785750	+	1059	WP_038242635.1	YcjF family protein	-
LGL88_RS08365 (LGL88_08390)	1785754..1786212	-	459	WP_145497061.1	RES domain-containing protein	Toxin
LGL88_RS08370 (LGL88_08395)	1786226..1786672	-	447	WP_038242631.1	DUF2384 domain-containing protein	Antitoxin
LGL88_RS08375 (LGL88_08400)	1786990..1788597	+	1608	WP_038251390.1	transcriptional regulator TyrR	-
LGL88_RS08380 (LGL88_08405)	1788632..1789135	-	504	WP_004717547.1	thiol peroxidase	-
LGL88_RS08385 (LGL88_08410)	1789285..1790259	+	975	WP_038275966.1	L-Ala-D/L-Glu epimerase	-
LGL88_RS08390 (LGL88_08415)	1790270..1790974	-	705	WP_004717543.1	murein tripeptide amidase MpaA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (3-147)

Antitoxin

• Antitoxin Xre/MbcA/ParS-like, toxin-binding domain (94-145)

Sequences

Toxin

Protein

• Length: 153 a.a.
• Molecular weight: 17044.50 Da
• Isoelectric Point: 6.6384

>T218955 WP_145497061.1 NZ_CP084641:c1786212-1785754 [Yersinia ruckeri]
VMLYRIVHNRYLATAWTGYGAETYGGRWNHKGHAAIYLASSVSLAMLETLVHVEDSATLNDFNLFQITIPDNAIMVLQQQ
DWPRGWRDDPTPVATMDIGTEWIGSASSVGLLVPSTLVPLERNMLVNPKHRDFASCLKSINPLTFSFDPRLK

Nucleotide

• Length: 459 bp

>T218955 NZ_CP116137:c135920-135615 [Escherichia coli]
ATGCAGTTTAAGGTTTACACCTATAAAAGAGAGAGCCGTTATCGTCTGTTTGTGGATGTACAGAGTGATATTATTGACAC
GCCCGGGCGACGGATGGTGATCCCCCTGGCCAGTGCACGTCTGCTGTCAGATAAAGTCTCCCGTGAACTTTACCCGGTGG
TGCATATCGGGGATGAAAGCTGGCGCATGATGACCACCGATATGGCCAGTGTGCCGGTCTCCGTTATCGGGGAAGAAGTG
GCTGATCTCAGCCACCGCGAAAATGACATCAAAAACGCCATTAACCTGATGTTCTGGGGAATATAA

Antitoxin

Protein

• Length: 149 a.a.
• Molecular weight: 16406.87 Da
• Isoelectric Point: 8.0956

>AT218955 WP_038242631.1 NZ_CP084641:c1786672-1786226 [Yersinia ruckeri]
MRTYHPSPMAKVSALWREIGLPASRGTALVDSIKLGFTVDVIDTIHLWADMPKSEILRATGIPSRSLTRRRTHDGRFTPE
ESERIARFVRVMDAAVDLFGGDRTKATAWMSMPVKGLGNRTPDSLLETETGALEICDLIGRLEHGVFS

Nucleotide

• Length: 447 bp

>AT218955 NZ_CP116137:c136140-135922 [Escherichia coli]
ATGAAGCAGCGTATTACAGTGACAGTTGACAGCGACAGCTATCAGTTGCTCAAGGCATATGATGTCAATATCTCCGGTCT
GGTAAGCACAACCATGCAGAATGAAGCCCGTCGTCTGCGTGCCGAACGCTGGAAAGCGGAAAATCAGGAAGGGATGGCTG
AGGTCGCCCGGTTTATTGAAATGAACGGCTCTTTTGCTGACGAGAACAGGGACTGGTGA

Structures

Antitoxin

• AlphaFold DB: A0A085U7R3