Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-Phd
Location 3131469..3132017 Replicon chromosome
Accession NC_008769
Organism Mycobacterium bovis BCG str. Pasteur 1173P2

Toxin (Protein)


Gene name relE Uniprot ID G0TFG5
Locus tag BCG_RS14870 Protein ID WP_003414602.1
Coordinates 3131754..3132017 (+) Length 88 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID O33347
Locus tag BCG_RS14865 Protein ID WP_003414599.1
Coordinates 3131469..3131750 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BCG_RS14840 3127092..3127949 - 858 WP_003899513.1 type I methionyl aminopeptidase -
BCG_RS14845 3127991..3128575 - 585 WP_010950792.1 DUF1707 domain-containing protein -
BCG_RS14850 3128679..3128927 + 249 WP_003913411.1 antitoxin VapB23 -
BCG_RS14855 3128924..3129304 + 381 WP_003414592.1 type II toxin-antitoxin system VapC family toxin -
BCG_RS14860 3129386..3131197 - 1812 WP_003414596.1 penicillin-binding protein -
BCG_RS14865 3131469..3131750 + 282 WP_003414599.1 type II toxin-antitoxin system antitoxin RelF Antitoxin
BCG_RS14870 3131754..3132017 + 264 WP_003414602.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
BCG_RS14875 3132390..3133244 - 855 WP_003899516.1 GNAT family N-acetyltransferase -
BCG_RS14880 3133300..3134463 - 1164 WP_003899517.1 flavodoxin-dependent (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase -
BCG_RS14885 3134480..3135694 - 1215 WP_011799297.1 zinc metalloprotease Rip -
BCG_RS14890 3135702..3136943 - 1242 WP_003414613.1 1-deoxy-D-xylulose-5-phosphate reductoisomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-72)


Sequences

Toxin        


Download         Length: 88 a.a.        Molecular weight: 10204.82 Da        Isoelectric Point: 11.5078

>T21895 WP_003414602.1 NC_008769:3131754-3132017 [Mycobacterium tuberculosis variant bovis BCG str. Pasteur 1173P2]
VPYTVRFTTTARRDLHKLPPRILAAVVEFAFGDLSREPLRVGKPLRRELAGTFSARRGTYRLLYRIDDEHTTVVILRVDH
RADIYRR

Download         Length: 264 bp

>T21895 NC_008769:3131754-3132017 [Mycobacterium tuberculosis variant bovis BCG str. Pasteur 1173P2]
GTGCCTTACACCGTGCGGTTCACCACAACCGCGCGTCGAGACCTCCACAAGCTGCCACCGCGAATCCTCGCGGCAGTGGT
CGAATTCGCGTTCGGCGATCTGTCGCGCGAGCCCCTGCGGGTGGGCAAGCCCCTTCGGCGCGAGTTGGCCGGCACGTTCA
GCGCGCGTCGCGGAACGTACCGCCTGCTGTACCGGATTGACGACGAGCACACAACGGTAGTGATCCTGCGCGTCGATCAC
CGCGCGGACATCTACCGCCGATAG

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10183.40 Da        Isoelectric Point: 4.3440

>AT21895 WP_003414599.1 NC_008769:3131469-3131750 [Mycobacterium tuberculosis variant bovis BCG str. Pasteur 1173P2]
MRILPISTIKGKLNEFVDAVSSTQDQITITKNGAPAAVLVGADEWESLQETLYWLAQPGIRESIAEADADIASGRTYGED
EIRAEFGVPRRPH

Download         Length: 282 bp

>AT21895 NC_008769:3131469-3131750 [Mycobacterium tuberculosis variant bovis BCG str. Pasteur 1173P2]
ATGCGGATACTGCCGATTTCGACGATCAAGGGCAAGCTCAATGAGTTCGTCGACGCGGTCTCGTCGACACAGGACCAGAT
CACCATCACCAAGAACGGTGCACCCGCAGCCGTTCTGGTCGGCGCCGACGAGTGGGAATCGTTGCAGGAGACGCTGTACT
GGCTGGCGCAACCCGGAATCAGGGAGTCGATCGCTGAAGCCGACGCCGACATTGCCTCCGGCCGCACCTACGGCGAAGAC
GAGATCCGCGCCGAATTCGGCGTCCCGCGACGCCCCCACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3G5O

Antitoxin

Source ID Structure
PDB 3G5O
AlphaFold DB A0A7U4BWP8

References