Detailed information of TA system TA218946

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 704941..705610
• Replicon: chromosome
• Accession: NZ_CP084641
• Organism: Yersinia ruckeri strain 17Y0163

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: A0A380QS17
• Locus tag: LGL88_RS03110
• Protein ID: WP_038241020.1
• Coordinates: 705188..705610 (+)
• Length: 141 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: -
• Locus tag: LGL88_RS03105
• Protein ID: WP_004719196.1
• Coordinates: 704941..705207 (+)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LGL88_RS03090 (LGL88_03095)	702278..702534	-	257	Protein_597	HD domain-containing protein	-
LGL88_RS03095 (LGL88_03100)	702851..703516	+	666	WP_175537887.1	hemolysin III family protein	-
LGL88_RS03100 (LGL88_03105)	703655..704647	-	993	WP_038241018.1	tRNA-modifying protein YgfZ	-
LGL88_RS03105 (LGL88_03110)	704941..705207	+	267	WP_004719196.1	FAD assembly factor SdhE	Antitoxin
LGL88_RS03110 (LGL88_03115)	705188..705610	+	423	WP_038241020.1	protein YgfX	Toxin
LGL88_RS03115 (LGL88_03120)	705758..706276	-	519	WP_038241022.1	flavodoxin FldB	-
LGL88_RS03120 (LGL88_03125)	706384..707283	+	900	WP_004719193.1	site-specific tyrosine recombinase XerD	-
LGL88_RS03125 (LGL88_03130)	707315..708031	+	717	WP_004719192.1	bifunctional protein-disulfide isomerase/oxidoreductase DsbC	-
LGL88_RS03130 (LGL88_03135)	708038..709771	+	1734	WP_038276198.1	single-stranded-DNA-specific exonuclease RecJ	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (2-132)

Antitoxin

• Flavinator of succinate dehydrogenase (7-79)

Sequences

Toxin

Protein

• Length: 141 a.a.
• Molecular weight: 16451.41 Da
• Isoelectric Point: 11.1478

>T218946 WP_038241020.1 NZ_CP084641:705188-705610 [Yersinia ruckeri]
VAQWRCDLRVSWRTQLFSLLVHGVLVLLTLVVPWPDGFTPLWLILLTLVVFECIRSQKNITSRQGEIRLKAGNLLIWKWQ
EWTLVRPPWITRYGVLLSLQGAGSRRRKRIWLASDSMSEEKWRELCLILRHTFDSAAGRE

Nucleotide

• Length: 423 bp

>T218946 NZ_CP116136:3674499-3674717 [Escherichia coli]
ATGTCCGAAAAACCTTTAACAAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10532.09 Da
• Isoelectric Point: 6.7185

>AT218946 WP_004719196.1 NZ_CP084641:704941-705207 [Yersinia ruckeri]
MEIDNKARIHWACRRGMRELDISIMPFFEHEYDTLNDNDKRVFIRLLTSDDPDLFNWLMNHGEPQDSELKRMVKLIQTRN
KARGPVAM

Nucleotide

• Length: 267 bp

>AT218946 NZ_CP116136:3674099-3674473 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGTCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTTAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGCAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Structures

Toxin

• AlphaFold DB: A0A380QS17