Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 974533..975156 Replicon chromosome
Accession NZ_CP084639
Organism Yersinia ruckeri strain 17Y0189

Toxin (Protein)


Gene name Hha Uniprot ID -
Locus tag LGL94_RS04430 Protein ID WP_049687933.1
Coordinates 974533..974736 (-) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A085U5C5
Locus tag LGL94_RS04435 Protein ID WP_004718732.1
Coordinates 974788..975156 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LGL94_RS04405 (LGL94_04395) 970391..970729 + 339 WP_007886947.1 P-II family nitrogen regulator -
LGL94_RS04410 (LGL94_04400) 970768..972056 + 1289 Protein_853 ammonium transporter AmtB -
LGL94_RS04415 (LGL94_04405) 972171..973034 - 864 WP_004718726.1 acyl-CoA thioesterase II -
LGL94_RS04420 (LGL94_04410) 973410..973724 - 315 WP_004718728.1 MGMT family protein -
LGL94_RS04430 (LGL94_04420) 974533..974736 - 204 WP_049687933.1 expression modulating protein YmoA Toxin
LGL94_RS04435 (LGL94_04425) 974788..975156 - 369 WP_004718732.1 Hha toxicity modulator TomB Antitoxin
LGL94_RS04440 (LGL94_04430) 976204..976365 + 162 WP_004718735.1 hypothetical protein -
LGL94_RS04445 (LGL94_04435) 976484..976627 - 144 WP_004718738.1 type B 50S ribosomal protein L36 -
LGL94_RS04450 (LGL94_04440) 976647..976901 - 255 WP_038243728.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8019.24 Da        Isoelectric Point: 6.4573

>T218932 WP_049687933.1 NZ_CP084639:c974736-974533 [Yersinia ruckeri]
MTKTDYLIRLRKCTTIDTLERVIEKNKYELSDDELELFYSAADHRLAELTMNKLYDKIPATVWQHVK

Download         Length: 204 bp

>T218932 NZ_CP116136:255084-255191 [Escherichia coli]
ATGACGCTCGCAGAACTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CATGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14277.08 Da        Isoelectric Point: 4.4225

>AT218932 WP_004718732.1 NZ_CP084639:c975156-974788 [Yersinia ruckeri]
MDEYSPKRHDIAQLKFLCENLYDEGIATLGDSHHGWVNDPTSAVNLQLNDLIEHIASFVMSFKIKYADEIDLCELVEEYL
DDTYTLFSSYGINDPDLRRWQKTKDRLFRLFSGEYLCALMKN

Download         Length: 369 bp

>AT218932 NZ_CP116136:c255035-254972 [Escherichia coli]
GTCTAGAGTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A085U5C5

References