Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 938581..939204 Replicon chromosome
Accession NZ_CP084637
Organism Yersinia ruckeri strain 17Y0412

Toxin (Protein)


Gene name Hha Uniprot ID A0A085U5C4
Locus tag LGL85_RS04255 Protein ID WP_038243726.1
Coordinates 938581..938784 (-) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A085U5C5
Locus tag LGL85_RS04260 Protein ID WP_004718732.1
Coordinates 938836..939204 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LGL85_RS04230 (LGL85_04240) 934437..934775 + 339 WP_007886947.1 P-II family nitrogen regulator -
LGL85_RS04235 (LGL85_04245) 934814..936102 + 1289 Protein_817 ammonium transporter AmtB -
LGL85_RS04240 (LGL85_04250) 936217..937080 - 864 WP_004718726.1 acyl-CoA thioesterase II -
LGL85_RS04245 (LGL85_04255) 937458..937772 - 315 WP_004718728.1 MGMT family protein -
LGL85_RS04255 (LGL85_04265) 938581..938784 - 204 WP_038243726.1 expression modulating protein YmoA Toxin
LGL85_RS04260 (LGL85_04270) 938836..939204 - 369 WP_004718732.1 Hha toxicity modulator TomB Antitoxin
LGL85_RS04265 (LGL85_04275) 940253..940414 + 162 WP_004718735.1 hypothetical protein -
LGL85_RS04270 (LGL85_04280) 940533..940676 - 144 WP_004718738.1 type B 50S ribosomal protein L36 -
LGL85_RS04275 (LGL85_04285) 940696..940950 - 255 WP_038243728.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8037.27 Da        Isoelectric Point: 6.4573

>T218920 WP_038243726.1 NZ_CP084637:c938784-938581 [Yersinia ruckeri]
MTKTDYLMRLRKCTTIDTLERVIEKNKYELSDDELELFYSAADHRLAELTMNKLYDKIPATVWQHVK

Download         Length: 204 bp

>T218920 NZ_CP116124:c40666-40532 [Escherichia coli]
ATGACGAAATATACCCTTATCGGGTTGCTTGCCGTGTGCGCCACGGTGTTGTGTTTTTCACTGATATTCAGGGAACAGTT
ATGTGAACTGAATATTCACAGGGGAAATACAGTGGTGCAGGTAACTCTGGCCTGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14277.08 Da        Isoelectric Point: 4.4225

>AT218920 WP_004718732.1 NZ_CP084637:c939204-938836 [Yersinia ruckeri]
MDEYSPKRHDIAQLKFLCENLYDEGIATLGDSHHGWVNDPTSAVNLQLNDLIEHIASFVMSFKIKYADEIDLCELVEEYL
DDTYTLFSSYGINDPDLRRWQKTKDRLFRLFSGEYLCALMKN

Download         Length: 369 bp

>AT218920 NZ_CP116124:40711-40771 [Escherichia coli]
TAAAGTGCATCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A085U5C4

Antitoxin

Source ID Structure
AlphaFold DB A0A085U5C5

References