Detailed information of TA system TA218910

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /RES-TIGR02293
• Location: 1954700..1955618
• Replicon: chromosome
• Accession: NZ_CP084635
• Organism: Yersinia ruckeri strain 17Y0414

Toxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: LGL86_RS08955
• Protein ID: WP_038242633.1
• Coordinates: 1955160..1955618 (+)
• Length: 153 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: A0A085U7R3
• Locus tag: LGL86_RS08950
• Protein ID: WP_038242631.1
• Coordinates: 1954700..1955146 (+)
• Length: 149 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LGL86_RS08930 (LGL86_08945)	1950398..1951102	+	705	WP_004717543.1	murein tripeptide amidase MpaA	-
LGL86_RS08935 (LGL86_08950)	1951113..1952087	-	975	WP_071706618.1	L-Ala-D/L-Glu epimerase	-
LGL86_RS08940 (LGL86_08955)	1952237..1952740	+	504	WP_004717547.1	thiol peroxidase	-
LGL86_RS08945 (LGL86_08960)	1952775..1954382	-	1608	WP_096823414.1	transcriptional regulator TyrR	-
LGL86_RS08950 (LGL86_08965)	1954700..1955146	+	447	WP_038242631.1	DUF2384 domain-containing protein	Antitoxin
LGL86_RS08955 (LGL86_08970)	1955160..1955618	+	459	WP_038242633.1	RES domain-containing protein	Toxin
LGL86_RS08960 (LGL86_08975)	1955622..1956680	-	1059	WP_038242635.1	YcjF family protein	-
LGL86_RS08965 (LGL86_08980)	1956677..1958074	-	1398	WP_004717556.1	YcjX family protein	-
LGL86_RS08970 (LGL86_08985)	1958055..1958297	-	243	WP_096823415.1	phage shock protein PspD	-
LGL86_RS08975 (LGL86_08990)	1958361..1958720	-	360	WP_004717559.1	envelope stress response membrane protein PspC	-
LGL86_RS08980 (LGL86_08995)	1958720..1958947	-	228	WP_038242637.1	envelope stress response membrane protein PspB	-
LGL86_RS08985 (LGL86_09000)	1959031..1959696	-	666	WP_038275968.1	phage shock protein PspA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (3-147)

Antitoxin

• Antitoxin Xre/MbcA/ParS-like, toxin-binding domain (94-145)

Sequences

Toxin

Protein

• Length: 153 a.a.
• Molecular weight: 17072.55 Da
• Isoelectric Point: 6.6384

>T218910 WP_038242633.1 NZ_CP084635:1955160-1955618 [Yersinia ruckeri]
VMLYRIVHNRYLATAWTGYGAETYGGRWNHKGHAAIYLASSVSLAMLETLVHVEDSATLNDFNLFQITIPDNAIMVLQQQ
DWPRGWRDDPTPVATMDIGTEWIGSVSSVGLLVPSTLVPLERNMLVNPKHRDFASCLKSINPLTFSFDPRLK

Nucleotide

• Length: 459 bp

>T218910 NZ_CP116123:3268196-3268582 [Escherichia coli]
ATGGGTGTGTATAAGGCAAGACGATTCAGCCAAAGCACGAAAAAACTTGGTATTCACGATAAAGTTCTCATGGCTGCCGC
TGAAGAAGTGATGCAGGGCATATGGGAGGCTGATTTAGGTAGCGGTGTCATCAAAAAACGTTTACCCCTCCAACAAGGAA
AGAGTGGTGGAGCCAGAACAATTATCTTTTTTAAATCAGCAAATCATGTGTTTTTTTATGATGGTTGGTCCAAGAGTGGT
CTAAGCAGTAAAGGAACCAAAGAAATCGAAGATGATGAACTGGCGGCCTACAAAAAAATGGCAAATGCATTTCTGGCCTT
TAGCAATAAGCAAATAGAGGATTTGATCGAAACTGGCTTTTTGATTGAGGTGAAAAATGAGCGATAA

Antitoxin

Protein

• Length: 149 a.a.
• Molecular weight: 16406.87 Da
• Isoelectric Point: 8.0956

>AT218910 WP_038242631.1 NZ_CP084635:1954700-1955146 [Yersinia ruckeri]
MRTYHPSPMAKVSALWREIGLPASRGTALVDSIKLGFTVDVIDTIHLWADMPKSEILRATGIPSRSLTRRRTHDGRFTPE
ESERIARFVRVMDAAVDLFGGDRTKATAWMSMPVKGLGNRTPDSLLETETGALEICDLIGRLEHGVFS

Nucleotide

• Length: 447 bp

>AT218910 NZ_CP116123:3268572-3268901 [Escherichia coli]
ATGAGCGATAAATTACAAATGATGCTGGAAGATGCAAAGGAACTGAATGCACTGGGCCTGATGTCTGATAGTGAAGTTGA
TGCCATTGCCGTCATGGTCAAAGCTCGTGAAGTCAGCGCCCGTATAGCCAAAGTCAAATCAATGACGGGTGAAGAGATCA
AAGCCATCCGCACCCGATACGGCATGTCACAATCCGTGCTGGCACATACAATGGGAATGTCAAAAGAAAGTGTCTCGAAA
TGGGAACGTAATGAAATAAAACCGAGCGGCCCGGCATTACGTATTTTGAATACATTGGCAATAAAAGGGCCGGAAGTTTT
TGCAAAGTAA

Structures

Antitoxin

• AlphaFold DB: A0A085U7R3